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Antioxidant activity of catecholamines as a chane of them antistress effect
- Authors: Shilov G.N.1, Ivanyutin V.A.2
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Affiliations:
- Minsk State Medical University
- National Academy of Belorussia
- Issue: Vol 12, No 2 (2014)
- Pages: 43-46
- Section: Articles
- Submitted: 21.10.2015
- Published: 15.06.2014
- URL: https://journals.eco-vector.com/RCF/article/view/740
- DOI: https://doi.org/10.17816/RCF12243-46
- ID: 740
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Abstract
The antioxidant activity of some native catecholamines (adrenaline, noradrenaline, dopamine), water-soluble antioxidant emoxipine, agonist (apomorphine) and antagonist (haloperidol) of dopamine receptors was assessed as their influence on malonic dialdehyde content and products of lipid peroxidation in homogenates and suspension of the rat cortical brain cells. All catecholamines (adrenaline, noradrenaline, dopamine in concentrations of 10-4 M and 10-5 M) possessed a high (compartable with emoxipine) antioxidant activity. The most antioxidant effect was registered in apomorphine. The inhibitory action of apomorphine on lipid peroxidation in the brain cortex can be a result from both dopamine receptor activation and “direct” antioxidant mechanism.
About the authors
Georgii Nolianovich Shilov
Minsk State Medical University
Email: George-Shilau@mail.ru
PhD, dozent, Dept. Of Neurology
Vladislav Adamovich Ivanyutin
National Academy of Belorussia
Email: u.ivaniutsin@gmail.com
PhD, Senior Researcher
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