Zinc, brain, behavior

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Abstract

The purpose of the review was to analyze current notions about role of essential trace element zinc in brain activity and therefore – in behavior. At the beginning of the review the basic data about zinc metabolism was described. The facts of zinc involvement into neurologic disorders and human cognition were represented. The results of the own investigation, devoted zinc peroral treatment and intrabrain microinjections influence on rats normal and pathological motor behavior were described. In particular, it is shown that zinc, depending on the dose and its mode of entry into the organism, can weaken and prevent the development of picrotoxin-induced neostriatal hyperkinesis (human Huntington horea analog), but it may aggravate hyperkinesis symptoms and even independently cause the motor stereotypy. On the basis of their own data and literary, it was suggested that neurons membranes structures are different sensitive to a certain zinc concentration and what does the specific way of behavior realization is ultimately depend.

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About the authors

Аndrey F. Yakimovskii

Pavlov First Medical University of St. Petersburg; Pavlov Institute of Physiology, Russian Academy of Science

Author for correspondence.
Email: jakim2010@gmail.com
SPIN-code: 7151-8991

Dr. Sci. (Med.), Professor

Russian Federation, 6/8 L’va Tolstogo str., Saint Petersburg, 197022; St. Petersburg

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