Varicella (chickenpox) has “matured” and become even more dangerous
- Authors: Neverov V.A.1, Kirpichnikova G.I.1, Antonov V.M.1, Startseva G.Y.1, Klur M.V.1
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 28, No 4 (2024)
- Pages: 5-15
- Section: Lectures
- Submitted: 18.02.2024
- Accepted: 07.03.2024
- Published: 15.12.2024
- URL: https://journals.eco-vector.com/RFD/article/view/627146
- DOI: https://doi.org/10.17816/RFD627146
- ID: 627146
Cite item
Abstract
This lecture focuses on varicella (chickenpox), one of the highly contagious diseases, the outbreaks of which can be effectively prevented through vaccination. It highlights modern aspects of the etiology, pathogenesis, epidemiology, clinical presentation, diagnosis, treatment, and prevention of varicella. Additionally, the lecture explores the clinical diversity of the disease’s forms and complications, including cases in newborns with perinatal infection. Compelling evidence characterizes varicella as a severe and “non-benign” infectious disease, which ranks among the leading causes of economic losses associated with infectious diseases in Russia.
The “maturation” of varicella observed in recent years has led to serious consequences, including more severe complications in adults compared to children, an increased economic burden, and a rising number of cases among pregnant women, resulting in higher rates of congenital and neonatal varicella. In light of increasing varicella incidence in Russia and several other countries, the data presented in this lecture are particularly valuable for practicing physicians, especially family doctors.
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About the authors
Vladimir A. Neverov
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: v.neveroff@mail.ru
ORCID iD: 0009-0003-7951-5508
SPIN-code: 1798-2618
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015Galina I. Kirpichnikova
North-Western State Medical University named after I.I. Mechnikov
Email: sotnik26@bk.ru
ORCID iD: 0009-0004-8767-2332
Cand. Sci. (Biology), Assistant Professor
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015Vsevolod M. Antonov
North-Western State Medical University named after I.I. Mechnikov
Email: Vsevolod.Antonov@szgmu.ru
ORCID iD: 0009-0002-3172-7926
SPIN-code: 9925-2139
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015Galina Yu. Startseva
North-Western State Medical University named after I.I. Mechnikov
Email: star661@rambler.ru
ORCID iD: 0000-0002-3660-2666
SPIN-code: 8392-2950
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015Margarita V. Klur
North-Western State Medical University named after I.I. Mechnikov
Email: rita-med@mail.ru
ORCID iD: 0009-0006-6222-2452
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 41 Kirochnaya St., Saint Petersburg, 191015References
- Skripchenko EYu, Ivanova GP, Skripchenko RV, et al. Modern view on the features of varicella in children and the possibility of specific prevention. Practical Medicine. 2021;19(2):8–13. EDN: SGSNSF doi: 10.32000/2072-1757-2021-2-8-13
- Varicella and herpes zoster vaccines: WHO position paper, June 2014. Wkly Epidemiol Rec. 2014;89(25):265–287.
- Vishneva EA, Kostinov MP, Mazankova LN, et al. Resolution of the expert forum of Russian federation “chickenpox: serious infection in Russian federation, which can be prevented due to vaccination” December 7, 2019. Current Pediatrics. 2019;18(6):491–494. EDN: YWVNKR
- Prikhodchenko NG. Varicella-pox virus infection: features of the course, clinical manifestations, complications, and possibilities for prevention. Therapeutic Archive. 2021;93(11):1401–1406. EDN: HYILYX doi: 10.26442/00403660.2021.11.201192
- Zryachkin NI, Buchkova TN, Chebotareva GI. Complications of chickenpox (literature review). Journal Infectology. 2017;9(3):117–128. EDN: ZMJFUN doi: 10.22625/2072-6732-2017-9-3-117-128
- Lobzin YuV, Skripchenko EYu, Karev VE, Palchik AB. Congenital chickenpox: urgency and clinical case. Russian Bulletin of Perinatology and Pediatrics. 2012;(2):64–70. EDN: PBBSRR
- Golovko MG, Poryadina GI, Larina VN. Varicella in adults at outpatient department. Lechebnoe delo. 2015;(4):40–44. EDN: VOUYFP
- Kokoreva SP, Ilunina LM, Kazartseva NV. The clinic and course of smallpox in actual conditions. Lechenie i profilaktika. 2016;(4(20)):13–20. EDN: XEIEUF
- LaRussa PhS, Marin M, Gershon AA. Varicella -Zoster Virus. In: Nelson Textbook of Pediatrics, 2-Volume Set. 21st Edition. Elsivier; 2019. Vol. 1, Sec. 13, Ch. 280. P. 1708–1715.
- Dekonenko EP, Shyshkina LV. The fatal outcome of encephalitis after chicken-pox in the patient with autoimmune disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2008;108(2):54–58. EDN: IJRUWN
- Svigunov VV, Ageev VA, Kanya DV. Two cases of disseminated form of varicella in adult patients with acquired immunodeficiency. Siberian medical journal (Irkutsk). 2001;27(3):80–82. EDN: PDAPVP
- Neverov VA, Zaplatnikov AL, Vasil’ev VV. Varicella -zoster virus infection (chickenpox and shingles). In: Korobkov NA, Vasil’ev VV, Lobzin YuV. Infections in Obstetrics: A guide for physicians. Saint Petersburg: SpetsLit; 2019. P. 364–367.
- Koltsova IV, Domonova EA, Silveystrova OYu, Kisteneva LB. Chicken pox and pregnancy: risks to mother and fetus. ways to solve the problem. Russian Bulletin of Perinatology and Pediatrics. 2021;66:(3):87–93. EDN: YSPJHQ doi: 10.21508/1027-4065-2021-66-3-87-93
- Bertelli A, Carta V, Mangeri L, et al. Varicella -zoster virus prevalence among pregnant women: a european epidemiological review. Life (Basel). 2023;13(2):593. doi: 10.3390/life13020593
- Nanthakumar MP, Sood A, Ahmed M, Gupta J. Varicella Zoster in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2021;258:283–287. doi: 10.1016/j.ejogrb.2021.01.009
- Harger JH, Ernest JM, Thurnau GR, et al. Risk factors and outcome of varicella -zoster virus pneumonia in pregnant women. J Infect Dis. 2002;185:422–427. doi: 10.1086/338832
- Bhavsar SM, Mangat C. Congenital Varicella Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK568794/. Accessed: 28 Nov 2024.
- Pupco A, Bozzo P, Koren G. Herpes zoster during pregnancy. Can Fam Physician. 2011;57(10):1133.
- Tan MP, Koren G. Chickenpox in pregnancy: revisited. Reprod Toxicol. 2006;21(4):410–420. doi: 10.1016/j.reprotox.2005.04.011
- National Advisory Committee on Immunization (NACI) update on varicella. Can Commun Dis Rep. 2004;30:1–26.
- Smirnova SS, Yuzhanina TS, Stepanova EA, Rupysheva TA. Chickenpox: a risk-based model for managing the epidemic process. The Far Eastern journal of infectious pathology. 2020;(39(39)):63–68. EDN: DASYML
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