Evaluation of early non-cognitive markers of dementia

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Abstract

Population aging is inextricably linked to an increase in the prevalence of dementia, which are one of the main causes of loss of autonomy in old age. However, early detection of cognitive decline is critical to proactively implementing interventions to slow the progression of cognitive decline and maintain the ability to live independently of outside help. Therefore, early detection of cognitive decline is one of the primary tasks of the general practitioner.

The aim of the lecture is to present a low gait speed, frailty, neuropsychiatric symptoms, sleep disorders and hearing loss as biomarkers of high risk to development of dementia risk and suggest ways measuring these risk factors in primary health care.

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About the authors

Gerald J. Jogerst

The University of Iowa

Author for correspondence.
Email: geraldjogerst@uiowa.edu
ORCID iD: 0000-0003-1072-673X
Scopus Author ID: 6603732741

Professor Emeritus Departments of Family Medicine, Department of Family Medicine, University of Carver College of Medicine, Pomerantz Family Pavilion

United States, 200 Hawkins Drive, Iowa City, IA

References

  1. Montero-Odasso M, Pieruccini-Faria F, Ismail Z, et al. CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus. Alzheimer’s Dement (NY). 2020;6(1):e12068. doi: 10.1002/trc2.12068
  2. Wang L, Larson EB, Bowen JD, van Belle G. Performance-based physical function and future dementia in older people. Arch Intern Med. 2006;166(10):1115–1120. doi: 10.1001/archinte.166.10.1115
  3. Gray SL, Anderson ML, Hubbard RA, et al. Frailty and incident dementia. J Gerontol A Biol Sci Med Sci. 2013;68(9):1083–1090. doi: 10.1093/gerona/glt013
  4. Dumurgier J, Artaud F, Touraine C, et al. Gait speed and decline in gait speed as predictors of incident dementia. J Gerontol A Biol Sci Med Sci. 2017;72(5):655–661. doi: 10.1093/gerona/glw110
  5. Montero-Odasso MM, Barnes B, Speechley M, et al. Disentangling cognitive-frailty: results from the gait and brain study. J Gerontol A Biol Sci Med Sci. 2016;71(11):1476–1482. doi: 10.1093/gerona/glw044
  6. Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci. 2013;68(4):412–418. doi: 10.1093/gerona/gls191
  7. Kueper JK, Speechley M, Lingum NR, Montero-Odasso M. Motor function and incident dementia: a systematic review and meta-analysis. Age Ageing. 2017;46(5):729–738. doi: 10.1093/ageing/afx084
  8. Verghese J, Wang C, Lipton RB, et al. Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry. 2007;78(9):929–935. doi: 10.1136/jnnp.2006.106914
  9. Ballard C, Day S, Sharp S, et al. Neuropsychiatric symptoms in dementia: importance and treatment considerations. Int Rev Psychiatry. 2008;20(4):396–404. doi: 10.1080/09540260802099968
  10. Almeida O, Hankey G, Yeap B, et al. Depression as a modifiable factor to decrease the risk of dementia. Transl Psychiatry. 2017;7(5):e1117. doi: 10.1038/tp.2017.90
  11. Singh-Manoux A, Dugravot A, Fournier A, et al. Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study. JAMA Psychiatry. 2017;74(7):712–718. doi: 10.1001/jamapsychiatry.2017.0660
  12. Tapiainen V, Hartikainen S, Taipale H, et al. Hospital-treated mental and behavioral disorders and risk of Alzheimer’s disease: a nationwide nested case-control study. Eur Psychiatry. 2017;43:92–98. doi: 10.1016/j.eurpsy.2017.02.486
  13. Creese B, Brooker H, Ismail Z, et al. Mild behavioral impairment as a marker of cognitive decline in cognitively normal older adults. Am J Geriatr Psychiatry. 2019;27(8):823–834. doi: 10.1016/j.jagp.2019.01.215
  14. Taragano FE, Allegri RF, Heisecke SL, et al. Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group. J Alzheimes Dis. 2018;62(1):227–238. doi: 10.3233/JAD-170632
  15. Matsuoka T, Ismail Z, Narumoto J. Prevalence of mild behavioral impairment and risk of dementia in a psychiatric outpatient clinic. J Alzheimes Dis. 2019;70(2):505–513. doi: 10.3233/JAD-190278
  16. Ismail Z, Smith EE, Geda Y, et al. Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimers Dement. 2016;12(2):195–202. doi: 10.1016/j.jalz.2015.05.017
  17. Ismail Z, Aguera-Ortiz L, Brodaty H, et al. The Mild Behavioral Impairment Checklist (MBI-C): A rating scale for neuropsychiatric symptoms in pre-dementia populations. J Alzheimers Dis. 2017;56(3):929–938. doi: 10.3233/JAD-160979
  18. Postuma RB, Iranzo A, Hu M, et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019;142(3):744–759. doi: 10.1093/brain/awz030
  19. Leng Y, Redline S, Stone KL, et al. Objective napping, cognitive decline, and risk of cognitive impairment in older men. Alzheimers Dement. 2019;15(8):1039–1047. doi: 10.1016/j.jalz.2019.04.009
  20. Lu Y, Sugawara Y, Zhang S, et al. Changes in sleep duration and the risk of incident dementia in the elderly Japanese: the Ohsaki Cohort 2006 Study. Sleep. 2018;41(10):zsy143. doi: 10.1093/sleep/zsy143
  21. Sindi S, Kareholt I, Johansson L, et al. Sleep disturbances and dementia risk: a multicenter study. Alzheimers Dement. 2018;14(10):1235–1242. doi: 10.1016/j.jalz.2018.05.012
  22. Suh SW, Han JW, Lee JR, et al. Sleep and cognitive decline: a prospective nondemented elderly cohort study. Ann Neurol. 2018;83(3):472–482. doi: 10.1002/ana.25166
  23. Shi L, Chen SJ, Ma MY, et al. Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev. 2018;40:4–16. doi: 10.1016/j.smrv.2017.06.010
  24. Hunter JC, Handing EP, Casanova R, et al. Neighborhoods, sleep quality, and cognitive decline: does where you live and how well you sleep matter? Alzheimers Dement. 2018;14(4):454–461. doi: 10.1016/j.jalz.2017.10.007
  25. De Almondes KM, Costa MV, Malloy-Diniz LF, Diniz BS. Insomnia and risk of dementia in older adults: systematic review and meta-analysis. J Psychiatr Res. 2016;77:109–115. doi: 10.1016/j.jpsychires.2016.02.021
  26. Blackwell T, Yaffe K, Laffan A, et al. Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. Sleep. 2014;37(4):655–663. doi: 10.5665/sleep.3562
  27. Diem SJ, Blackwell TL, Stone KL, et al. Measures of sleep-wake patterns and risk of mild cognitive impairment or dementia in older women. Am J Geriatr Psychiatry. 2016;24(3):248–258. doi: 10.1016/j.jagp.2015.12.002
  28. Loughrey DG, Kelly ME, Kelley GA, et al. Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systemic review and meta-analysis. JAMA Otolaryngol Head Neck Surg. 2018;144(2):115–126. doi: 10.1001/jamaoto.2017.2513
  29. Wei J, Hu Y, Zhang L, et al. Hearing impairment, mild cognitive impairment and dementia: a meta-analysis of cohort studies. Dement Geriatr Cogn Dis Extra. 2017;7(3):440–452. doi: 10.1159/000485178
  30. Thomson RS, Auduong P, Miller AT, Gurgel RK. Hearing loss as a risk factor for dementia: a systemic review. Laryngoscope Investig Otolaryngol. 2017;2(2):69–79. doi: 10.1002/lio2.65
  31. Montero-Odasso M, Oteng-Amoako A, Speechley M, et al. The motor signature of mild cognitive impairment: results from the gait and brain study. J Gerontol A Biol Sci Med Sci. 2014;69(11):1415–1421. doi: 10.1093/gerona/glu155
  32. Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci. 2013;68(4):412–418. doi: 10.1093/gerona/gls191
  33. Camargo EC, Weinstein G, Beiser AS, et al. Association of physical function with clinical and subclinical brain disease: the framingham offspring study. J Alzheimers Dis. 2016;53(4):1597–1608. doi: 10.3233/JAD-160229
  34. Buchman AS, Wilson RS, Boyle PA, et al. Grip strength and the risk of incident Alzheimer’s disease. Neuroepidemiology. 2007;29(1–2):66–73. doi: 10.1159/000109498
  35. Waite LM, Grayson DA, Piguet O, et al. Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. J Neurol Sci. 2005;229–230:89–93. doi: 10.1016/j.jns.2004.11.009
  36. Camicioli R, Wang Y, Powell C, et al. Gait and posture impairment, parkinsonism and cognitive decline in older people. J Neural Transm (Vienna). 2007;114(10):1355–1361. doi: 10.1007/s00702-007-0778-5
  37. Jessen F, Amariglio RE, Buckley RF, et al. The characterization of subjective cognitive decline. Lancet Neurol. 2020;19(3):271–278. doi: 10.1016/S1474-4422(19)30368-0
  38. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi: 10.1111/j.1532-5415.2005.53221.x
  39. Shin C, Park MH, Lee SH, et al. Usefulness of the 15-item geriatric depression scale (GDS-15) for classifying minor and major depressive disorders among community-dwelling elders. J Affect Disord. 2019;259:370–375. doi: 10.1016/j.jad.2019.08.053
  40. Kroenke K, Spitzer RL, Williams JBW, Lowe B. The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry. 2010;32(4):345–359. doi: 10.1016/j.genhosppsych.2010.03.006
  41. Podsiadlo D, Richardson S. The timed “Up and Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–148. doi: 10.1111/j.1532-5415.1991.tb01616.x
  42. Woo J, Yu R, Wong M, et al. Frailty screening in the community using the frail scale. J Am Med Dir Assoc. 2015;16(5):412–419. doi: 10.1016/j.jamda.2015.01.087

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