Этот специфически неспецифичный стресс глазами генетика: путь "Press–Stress–Gress"
- Авторы: Даев Е.В.1,2
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Учреждения:
- Санкт-Петербургский государственный университет, Санкт-Петербург
- ФГБУН Институт физиологии им. И.П. Павлова РАН, Санкт-Петербург
- Раздел: Мнения, гипотезы, дискуссионные вопросы
- Статья получена: 13.02.2025
- Статья одобрена: 26.06.2025
- Статья опубликована: 26.06.2025
- URL: https://journals.eco-vector.com/ecolgenet/article/view/655848
- DOI: https://doi.org/10.17816/ecogen655848
- ID: 655848
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Аннотация
Биологическая концепция "стресса", изложенная в работах Г. Селье создала целое научное направление. Она играла и продолжает играть большую роль в развитии биомедицинских исследований. Научный прогресс ведет к наполнению термина "стресс" новым биологическим содержанием на разных уровнях изучения. При этом неоправданное расширение часто ведет к размытию понятия, засорению "криптическими" терминами, усложняющими понимание явления.
Цель работы состоит в обсуждении некоторых моментов затрудняющих или искажающих научное содержание термина "стресс". С генетической точки зрения, предложено рассматривать явление, как состояние, возникающее при невозможности организма адаптироваться в пределах его нормы реакции, определяемой генотипом.
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Об авторах
Евгений Владиславович Даев
Санкт-Петербургский государственный университет, Санкт-Петербург; ФГБУН Институт физиологии им. И.П. Павлова РАН,Санкт-Петербург
Автор, ответственный за переписку.
Email: e.daev@spbu.ru
ORCID iD: 0000-0003-2036-6790
SPIN-код: 8926-6034
Scopus Author ID: 6701779129
ResearcherId: D-1165-2013
д.б.н., профессор кафедры генетики и биотехнологии; д. б. н.; вед. научный сотрудник, лаборатория генетики высшей нервной деятельности
Россия, Университетская наб.,7/9, кафедра генетики и биотехнологии Биологического факультета Санкт-Петербургского Государственного университета, Санкт Петербург; наб. Макарова, 6, лаборатория генетики высшей нервной деятельности Института физиологии им. И.П.Павлова РАН, Санкт-ПетербургСписок литературы
- Feynman RP. Surely you're joking, Mr. Feynman: adventures of a curious character. N.Y.: WW Norton, 1997.
- Kültz D. Defining biological stress and stress responses based on principles of physics. J. Exp. Zool. A Ecol. Integr. Physiol. 2020;333:350-358. doi: 10.1002/jez.2340 EDN: CILZSQ
- Selye H. From dream to discovery. On being scientist. N.Y.: McGrow-Hill, 1964. (Cit. by: Selye H. Ot mechty k otkrytiyu. Kak stat' uchenym. M.: Progress. 1987.).
- Selye H. A Syndrome produced by Diverse Nocuous Agents. Nature. 1936;138:32-33. doi: 10.1038/138032a0
- Selye H. The story of the adaptation syndrome. (Told in the form of informal, illustrated lectures). Montreal: Acta, 1952.
- Selye H. Confusion and controversy in the stress field. J Human Stress. 1975;1(2):37-44. doi: 10.1080/0097840X.1975.9940406
- Mojica EA, Kültz D. Physiological mechanisms of stress-induced evolution. Journal of Experimental Biology. 2022:225, jeb243264. doi: 10.1242/jeb.2432642022
- Selye H. The stress of life. New York: McGraw-Hill Book Co.; 1956.
- Fortier C, Selye H. Adrenocorticotrophic effect of stress after severance of the hypothalamo-hypophyseal pathways. Am J Physiol. 1949;159(3):433-439. doi: 10.1152/ajplegacy.1949.159.3.433
- Hoffmann, AA, Hercus, MJ. Environmental Stress as an Evolutionary Force. BioScience. 2000;50(3):217-226. doi: 10.1641/0006-3568(2000)050[0217:ESAAEF]2.3.CO;2 EDN: LUFDNR
- Yaribeygi H, Panahi Y, Sahraei H, Johnston TP. The Impact of Stress on Body Function: a Review. EXCLI Journal. 2017;16:1057-1072. doi: 10.17179/excli2017-480 EDN: YHFEJI
- Sun S, Zhou J. Molecular mechanisms underlying stress response and adaptation. Thoracic Cancer. 2018;9:218-227. doi: 10.1111/1759-7714.12579 EDN: YDWPAL
- Selye H. In vivo. The case for supramolecular biology presented in six informal, illustrated lectures. Foreword: Albert Szent-Györgyi. New York: Liveright, 1967.
- Eremina MA., Gruntenko NE. The neuroendocrine stress-response in insects: the history of the development of the concept. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2017;21(7):825-832. doi: 10.18699/VJ17.302(inRus.) EDN: ZUCIIV
- Sharma DK. Physiology of Stress and its Management. J Med Stud Res. 2018;1: 001. doi: 10.24966/MSR-5657/100001
- Harkness KL, Hayden EP, Lopez-Duran NL. Stress sensitivity and stress sensitization in psychopathology: An introduction to the special section. Journal of Abnormal Psychology. 2015;124(1):1-3. doi: 10.1037/abn0000041
- Kageyama, K, Nemoto T. Molecular Mechanisms Underlying Stress Response and Resilience. Int. J. Mol. Sci. 2022, 23, 9007. doi: 10.3390/ijms23169007 EDN: TPGPNR
- Kolesnik EA. Stress-reakciya kak zashchitnyj immunnyj mekhanizm, napravlennyj na vosstanovlenie gomeostaza organizma. Vestnik CHelyabinskogo gosudarstvennogo universiteta.Obrazovanie i zdravoohranenie. 2020;4(12):5-14. (In Rus.). doi: 10.24411/2409-4102-2020-10401
- James KA, Stromin JI, Steenkamp N and Combrinck MI (2023) Understanding the relationships between physiological and psychosocial stress, cortisol and cognition. Front. Endocrinol. 2023;14:1085950. doi: 10.3389/fendo.2023.1085950
- Kyrou I, Tsigos C. Stress mechanisms and metabolic complications. Horm Metab Res. 2007;39(6):430-8. doi: 10.1055/s-2007-981462
- Tsigos C, Kyrou I, Kassi E, Chrousos GP. Stress: Endocrine Physiology and Pathophysiology. [Updated 2020 Oct 17]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK278995.
- Ising M, Holsboer F. Genetics of stress response and stress-related disorders, Dialogues in Clinical Neuroscience. 2006;8(4):433-444. doi: 10.31887/DCNS.2006.8.4/missing
- Lempesis IG, Georgakopoulou VE, Papalexis P, Chrousos GP, Spandidos DA. Role of stress in the pathogenesis of cancer (Review). Int. J. Oncol. 2023;63:124. doi: 10.3892/ijo.2023.5572 EDN: EYPHVX
- Del Giudice M, Buck CL, Chaby LE, Gormally BM, Taff CC, Thawley CJ, Vitousek MN, Wada H. What Is Stress? A Systems Perspective. Integrative and Comparative Biology. 2018;58(6):1019-1032. doi: 10.1093/icb/icy114
- Day TA. Defining stress as a prelude to mapping its neurocircuitry: No help from allostasis. Progress in Neuro-Pharmacology and Biological Psychiatry. 2005;29(8): 1195-1200. doi: 10.1016/j.pnpbp.2005.08.005
- Davies K.J.A. Adaptive homeostasis. Molecular Aspects of Medicine. 2016;49P:1-7. doi: 10.1016/j.mam.2016.04.007
- Fink G. 2016. Stress, Definitions, Mechanisms, and Effects Outlined: Lessons from Anxiety. In: Fink G, ed. Stress: Concepts, Cognition, Emotion, and Behavior, Vol. 1 of the Handbook of Stress Series. San Diego: Elsevier Inc., 2016: 3-11. doi: 10.1016/B978-0-12-800951-2.00001-7
- Selye H. Stress without distress. Philadelphia: Lippincott, 1974.
- Selye H. Stress in Health and Disease. Boston (MA): Butterworths, Stoneham, 1976.
- Fink, G. (2017) Stress: Concepts, Definition and History. In Reference Module Inneuroscience and Biobehavioral Psychology, Elsevier Inc., Amsterdam, 1-9. doi: 10.1016/B978-0-12-809324-5.02208-2 EDN: CLOCJP
- Ishaque S, Khan N, Krishnan S. Physiological Signal Analysis and Stress Classification from VR Simulations Using Decision Tree Methods. Bioengineering. 2023;10:766. doi: 10.3390/bioengineering10070766 EDN: RLQXYO
- Patochkina NA, Komel'kova MV, Cejlikman OB, Lapshin MS. Stress: psihologicheskie, biohimicheskie i psihofiziologicheskie aspekty: uchebnoe posobie. CHelyabinsk: Izdatel'skij centr YUUrGU; 2017. (In Russ).
- Lu S, Wei F, Li G. The evolution of the concept of stress and the framework of the stress system. Cell Stress. 2021;5(6):76-85. doi: 10.15698/cst2021.06.250 EDN: PBWDTK
- Coffman JA. Chronic stress, physiological adaptation and developmental programming of the neuroendocrine stress system. Future Neurol. 2020;15(1), FNL39. doi: 10.2217/fnl-2019-0014 EDN: LRTWSG
- Markel' AL. Povedenie, stress i evolyuciya. Filosofiya nauki. 2013;1(56):140-152 (In Russ.). URL: https://rucont.ru/efd/220799 (data obrashcheniya: 25.04.2024).
- Stanojlović O., Šutulović N., Mladenović D., Zubelić A., Hrnčić D., Rašić-Marković A., Vesković M. Neurophysiology of stress - from historical to modern approach. Medicinska istaživanja. 2022; 55(1):51-57. doi: 10.5937/medi55-37829
- Koolhaas JM, Bartolomucci A, Buwalda B, de Boer SF, Flügge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgoifo A, Steimer T, Stiedl O, van Dijk G, Wöhr M, Fuchs E. Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev. 2011;35(5):1291-301. doi: 10.1016/j.neubiorev.2011.02.003
- Mel'nikova ML. Psihologiya stressa: teoriya i praktika [Elektronnyj resurs]: uchebno-metodicheskoe posobie. (Maksimova L. A., editor). Ekaterinburg: Ural. gos. ped. un-t. 2018 (In Russ.).
- Bernard C. Lectures on the phenomena of life common to animals and plants. Vol. 1. Hoff HE, Guillemin R, Guillemin L (1878). Trans. Springfield (IL): Charles C Thomas; 1974.
- Cannon WB. The wisdom of the body. New York: W.W. Norton & Co., Inc.; 1932. doi: 10.1097/00000441-193212000-00028
- Johannsen W. The Genotype Conception of Heredity. The American Naturalist. 1911;45(531):129-159. http://www.jstor.org/stable/2455747 (Accessed: 15-06-2024). doi: 10.1086/279202
- Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 2015;160(5):816-827. doi: 10.1016/j.cell.2015.02.010 EDN: XMLPPD
- Chatterjee N., Walker GC. Mechanisms of DNA Damage, Repair, and Mutagenesis. Environmental and Molecular Mutagenesis. 2017;58:235-263. doi: 10.1002/em.22087 EDN: VOQYVV
- Horne SD, Chowdhury SK, Heng HHQ. Stress, genomic adaptation, and the evolutionary trade-off. Frontiers in Genetics. 2014;14(5):92. doi: 10.3389/fgene.2014.00092 EDN: SOYGNT
- Erol A. Genotoxic stress-mediated cell cycle activities for the decision of cellular fate. Cell Cycle. 2011;10(19): 3239-3248. doi: 10.4161/cc.10.19.17460
- Valente VB, de Melo Cardoso D, Kayahara GM, Nunes GB, Tjioe KC, Biasoli ÉR, Miyahara GI, Oliveira SHP, Mingoti GZ, Bernabé DG. Stress hormones promote DNA damage in human oral keratinocytes. Scientific Reports. 2021;11:19701. doi: 10.1038/s41598-021-99224-w
- Parsons PA. Evolutionary rates: effects of stress upon recombination. Biological Journal of the Linnean Society. 1988;35: 49-68. doi: 10.1111/j.1095-8312.1988.tb00458.x EDN: XWLFQN
- Fischman HK, Kelly DD. Chromosomes and stress. Int. J. Neurosci. 1999;99:201-19. doi: 10.3109/00207459908994325 EDN: LOCMLT
- El-Refaiy AI, El-Desouki NI, Abdel-Azeem H, Elbaely MM. Cytogenetical study on the Effect of Immobilization Stress on Albino Rat and the Ameliorative Role of Diazepam. Curr. Sci. Int. 2017;6(4):900-907.
- Pappalardo AM, Ferrito V, Biscotti MA, Canapa A, Capriglione T. Transposable Elements and Stress in Vertebrates: An Overview. Int. J. Mol. Sci. 2021;22:1970. doi: 10.3390/ijms22041970 EDN: UBEXGE
- Daev EV. Genetic Aspects of Stress Neuroendocrinology // In: Penkava NS, Haight LR, editors. Neuroendocrinology Research Developments. Hauppauge, New York: Nova Science Publishers, Inc., 2010. P. 119-133.
- Galhardo RS, Hastings PJ, Rosenberg SM. Mutation as a stress response and the regulation of evolvability. Crit Rev Biochem Mol Biol. 2007;42(5):399-435. doi: 10.1080/10409230701648502
- Fitzgerald DM, Rosenberg SM. What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis. PLoS Genet. 2019 Apr 1;15(4):e1007995. doi: 10.1371/journal.pgen.1007995 EDN: TQTPWN
- Pribis JP, Zhai Y, Hastings PJ, Rosenberg SM. 2022. Stress-Induced Mutagenesis, Gambler Cells, and Stealth Targeting Antibiotic-Induced Evolution. mBio 13:e01074-22. doi: 10.1128/mbio.01074-22
- Goldstein DS, Kopin IJ. Evolution of concepts of stress. Stress. 2007;10(2):109-120. doi: 10.1080/10253890701288935
- Ramsay DS, Woods SC. Clarifying the roles of homeostasis and allostasis in physiological regulation. Psychol Rev. 2014;121(2):225-47. doi: 10.1037/a0035942
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