К ПОНИМАНИЮ МЕХАНИЗМОВ ЭПИГЕНЕТИЧЕСКОЙ РЕГУЛЯЦИИ: ЧАСТЬ I. ЭВОЛЮЦИОННЫЙ ВЗГЛЯД НА PcG-ЗАВИСИМУЮ РЕПРЕССИЮ ГЕНОВ



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Аннотация

Эволюционно консервативные белки группы PcG обеспечивают стабильную эпигенетическую репрессию транскрипции, инициированную на более ранних этапах короткоживущими регуляторными белками. Точный механизм PcG-зависимой репрессии пока не расшифрован; в данной работе мы приводим существующие модели этой репрессии. Мы также кратко суммируем имеющиеся данные о белках группы PcG и их роли в различных процессах и рассматриваем эволюцию комплексов PRC1 и PRC2.

Об авторах

Елена Михайловна Федорова

Институт Физиологии им. И. П. Павлова РАН, Санкт-Петербург, РФ

Email: ellena_fedorova@yahoo.com

Александр Викентьевич Родионов

Ботанический институт им. В.Л. Комарова РАН, Санкт-Петербург, РФ

Email: avrodionov@mail.ru

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