Morphological study of idiopathic epiretinal membranes and their cytokine profile

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The article presents comparative morphological analysis and assessment of response to antigens of fibronectin, laminin, glial fibrillary acidic protein (GFAP) in idiopathic epiretinal membranes (iERM). Authors found a comparable positive iERM reaction to fibronectin and GFAP, which indicates the involvement of these cytokines in the development and progression of the posterior segment neurodegenerative process. Cellular elements in the vitreous gel responsible for iERM formation were fibroblasts, myofibroblasts, hyalocytes, and retinal radial glial cells. Retinal radial glial cells play the main role in the recurrent iERM formation.

Conclusion. Due to its hemodynamic, nootropic, neurotrophic action, the investigated bioregulatory complex increases the optic nerve tolerance to the stress effect of IOP, SBP, and DBP asynchronous fluctuations, and improves the ocular blood perfusion.

Ural R Altynbaev

Author for correspondence.
OAO “Tatneft”
Russian Federation

MD, PhD. Ophthalmology Department, Medical Unit

Anna I Lebedeva
Federal State Institution “All-Russian Eye and Plastic Surgery Center”
Russian Federation

PhD, head of histology and immunohistochemistry laboratory. Morphology Department

  • Алтынбаев У.Р. Оценка уровня гликопротеинов в стекловидном теле при различных дегенеративных заболеваниях центральной области сетчатки // Казанский медицинский журнал. – 2015. – Т. 96. – № 3. – С. 358–360. [Altynbaev UR. Ocenka urovnja glikoproteinov v steklovidnom tele pri razlichnyh degenerativnyh zabolevanijah central’noj oblasti setchatki. Kazanskij medicinskij zhurnal. 2015;96(3):358-360. (In Russ.)]
  • Bravo R, Macdonald-Bravo H. Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication. EMBO J. 1985;4(3):655-61.
  • Fraser-Bell SI, Guzowski M. Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study. Ophthalmology. 2003;110(1):34-40. doi: 10.1016/S0161-6420(02)01443-4.
  • Foos RY. Vitreoretinal juncture; topographical variations. Invest Ophthalmol Vis Sci. 1972;11:801.
  • Hikichi T, Takahashi M. Relationship between premacular cortical vitreous defects and idiopathic premacular fibrosis. Retina. 1995;15(5):413-416. doi: 10.1097/00006982-199515050-00007.
  • Grisanti SI, Heimann K, Wiedemann P. Origin of fibronectin in epiretinal membranes of proliferative vitreoretinopathy and proliferative diabetic retinopathy. Br J Ophthalmol. 1993;77(4):238-42.
  • Guidry C. Isolation and characterization of porcine Müller cells. Myofibroblastic dedifferentiation in culture. Invest Ophthalmol Vis Sci. 1996;37(5):740-52. doi: 10.1136/bjo.77.4.238.
  • Kohno RI, Hata Y. Possible contribution of hyalocytes to idiopathic epiretinal membrane formation and its contraction. Br J of Ophthalmology. 2009;93(8):1020-1026. doi: 10.1136/bjo.2008. 155069.
  • Kishi S, Demaria C. Vitreous cortex remnants at the fovea after spontaneous vitreous detachment. International Ophthalmology. 1986;9(4):253-260. doi: 10.1007/BF00137539.
  • Mandal N, Kofod M. Proteomic analysis of human vitreous associated with idiopathic epiretinal membrane. Acta Ophthalmologica. 2013;91(4):333-334. doi: 10.1111/aos.12075.
  • Schumann RG, Eibl KH, Zhao F, et al. Immunocytochemical and ultrastructural evidence of glial cells and hyalocytes in internal limiting membrane specimens of idiopathic macular holes. Investigative Ophthalmology and Visual Science. 2011;52(11):7822-7834. doi: 10.1167/iovs.11-7514.
  • Snead DR, Cullen N. Hyperconvolution of the inner limiting membrane in vitreomaculopathies. Graefes Arch Clin Exp Ophthalmol. 2004;242(10):853-862. doi: 10.1007/s00417-004-1019-3.
  • Weller MI, Wiedemann P. The significance of fibronectin in vitreoretinal pathology. A critical evaluation. Graefes Arch Clin Exp Ophthalmol. 1988;226(3):294-298. doi: 10.1007/BF02181200.


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