Differences in the pathogenesis of the uterine cervix cancer

Abstract

Objective: The purpose of the research was the analysis of a number of factors, characteristic for an arrangement of the uterine cervix cancer in exocervix or endocervix for a substantiation of a hypothesis about pathogenetic heterogeneity of this disease.

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Methods: The retrospective analysis comparing 505 patients with uterine cervix cancer (I-III clinical stage) treated in Prof. N.N. Petrov Institute of Oncology was performed. Women aged from 20 to 75 years old received surgical or combined treatment. The statistical analysis of endogenous (associated with endocrine - exchange pathology) and exogenous (the reproductive function intensity, smoking, background diseases of the uterine cervix) factors is carried out depending on localization of tumor in exocervix or endocervix.

Results: For localization of a tumor in endocervix (both for squamous cell and adenocarcinoma) the association with the factors connected to endocrine-exchange violations, such as myoma, ovarian stromal hyperplasia, genital endometriosis, hypertonia, fattens, diabetes is characteristic. The cancer of endocervix more often meets in patients of menopausal age. The cancer of exocervix is connected with young (reproductive) age of patients and exogenous factors, such as background diseases of the uterine cervix, smoking, intensive reproductive function, sexual activity.

Conclusion: The received data allow to put forward a hypothesis about pathogenetic heterogeneity of the uterine cervix cancer and various variants of its development in dependence on localization of the tumor.