Journal of obstetrics and women's diseases

Peer-review medical journal


Eduard K. Ailamazyan, MD, PhD, Academician of the Russian Academy of Sciences

The Journal has been issued since 1887. It is the first scientific journal in Russia for obstetricians and gynecologists. For over a century, the Journal regularly covers the latest achievements of Russian science.

Journal of Obstetrics and Women's Diseases, a Gold Open Access journal, publishes six volumes per year. Additionally, the Journal will publish occasional special issues featuring selected papers from major conferences.

Abstracting and Indexing

  • Russian Science Citation Index (RSCI) on Web of Science
  • elibrary
  • Google Scholar
  • Ulrich's Periodicals Directory
  • WorldCat

Journal Topics

Journal of Obstetrics and Women's Diseases is a scientific and practical peer-reviewed medical journal, which discusses the most pressing health issues:

  • reproductive health;
  • results of clinical and sociological research;
  • current problems in perinatal obstetrics;
  • issues of gynecological endocrinology, pregravid preparation, and family planning;
  • actual problems in operative gynecology;
  • diagnostics and therapy of reproductive tract infections;
  • advances in clinical genetics and prenatal diagnosis of hereditary and congenital diseases, immunology, and pathology;
  • new and important information and recommendations for the practical physicians (introduction of modern diagnostic and therapeutic technologies, the use of effective drugs, etc.);
  • impact of harmful environmental and production factors on the female reproductive system.

Journal Mission

The main mission of the Journal is to provide new scientific and technical information, to promote scientific knowledge, to help obstetricians and gynecologists to choose the best methods of diagnosis and treatment, and to help improve their skills.

The publications of the Journal are of interest to a wide range of scholars in the field of obstetrics, gynecology, reproduction, genetics, pathology, and immunology of reproduction, as well as for medicine and biology tutors and students.

The Journal is published with the assistance of:

  • Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
  • Society of Obstetricians and Gynecologists of St. Petersburg and North-West Region of Russia
  • Military Medical Academy named after S.M. Kirov of the Ministry of Defence of the Russian Federation



Journal of obstetrics and woman diseases indexing in SCOPUS

In September 2020 the Journal of obstetrics and woman diseases have been recommended for indexing in SCOPUS.

Posted: 20.09.2020
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Current Issue

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Vol 69, No 4 (2020)

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Original Researches
Possibilities for predicting perineal birth injury
Ziganshin A.M., Mudrov V.A.

Hypothesis/aims of study. To date, intranatal injuries of the genital tract and their adverse effects on the woman’s body remain one of the most important issues in obstetrics and gynecology. Despite the improved management of childbirth, the frequency of the birth canal tissue injuries has no tendency to decrease and amounts to 10.2–39.0%. The aim of this study was to assess the possibility for predicting intranatal perineal injuries.

Study design, materials and methods. The study included a prospective analysis of 90 cases of labor through the natural birth canal based on data obtained from Ufa and Chita perinatal centers in the years 2017–2019. To determine the elasticity of perineal tissues, a perineoelastomer has been developed, which allows expressing the elasticity of the vulvar ring tissues by a special conditional coefficient. Data was processed using the IBM SPSS Statistics V25.0 software package.

Results. Based on the assessment of the obtained data, a probability coefficient of perineal injuries was developed. Its calculation is based on a nonlinear regression analysis and is expressed by the formula: T = (100 ∙ CFH) / (PAA ∙ FBD ∙ ε ∙ π), where CFH is the circumference of the fetal head at the level of visual tubercles (mm), PAA is the pubic arch angle (degrees), FBD is the distance from the front to the back of the adhesion of the vulvar ring (cm), ε is the coefficient of elastic deformation of the perineum. When the coefficient T is more than 1, perineal rupture in labor is predicted.

Conclusion. In the development of obstetric injuries of the perineum, a major role is played by the ratio of the circumference of the fetal head and the maximum perimeter of the extension of a vulvar ring, which, together with the value of the pubic arch angle and the coefficient of elastic deformation of the perineum, may be a criterion in favor of performing surgical protection of the perineum in case of a threatening rupture.

Journal of obstetrics and women's diseases. 2020;69(4):5-11
Possibilities of geometric modeling in reducing the error of estimated fetal weight calculation
Mudrov V.A.

Hypothesis/aims of study. The aim of this study was to evaluate the possibilities of geometric modeling in reducing the error of estimated fetal weight calculation.

Study design, materials and methods. During the first stage of the study, a mathematical dependency was determined by geometric modeling of the results of an objective examination of the pregnant woman, which hypothetically will reduce the error of estimated fetal weight calculation. The second stage of the study included a prospective analysis of the error of the developed method and standard formulas for estimated fetal weight calculation at full-term pregnancy, and the third stage at preterm pregnancy. Weighing the newborn is the gold standard, which allows to objectively assess the error of the studied formulas.

Results. The average value of the relative error of fetal weight calculation using the Jordania’s formula was 14,2%, the Johnson’s 18,6%, the Lankowitz’s 16,2%, the Yakubova’s 12,2%, the Rudakov’s method 14,3%, and the developed formula 9,0%.

Conclusion. The data obtained confirmed the high importance of geometric modeling in reducing the error of estimated fetal weight calculation.

Journal of obstetrics and women's diseases. 2020;69(4):13-22
Prediction of placental insufficiency in pregnant women with different somatotypes
Tomayeva K.G.

Hypothesis/aims of study. Poor placental vascularization can lead to placental insufficiency, due to which the metabolism of nutrients and microelements between the maternal and fetal blood circulations subsequently decreases. Due to poor perfusion of placental vessels, placental dysfunction occurs. Chronic fetal hypoxia causes fetal growth retardation. The aim of this study was to assess the frequency of placental insufficiency in women with different somatotypes and to develop a model for predicting the risk of this pathology.

Study design, materials and methods. A total of 390 women were examined, of whom 110 were macrosomatic, 173 mesosomatic, and 107 microsomatic. Somatometry was performed according to R.N. Dorokhov for women in the early stages of pregnancy (up to 9-10 weeks). Placental insufficiency markers (VEGF, PlGF, IL-6, and endocan-1) were determined spectrophotometrically in blood serum at the gestational age of 12–13 and 22–23 weeks using ELISA methods.

Results. Placental insufficiency was significantly more prevalent among the women of the macro- and microsomatic body type compared with those of mesosomatotypes (p < 0.05). In pregnant women with subsequent placental insufficiency, VEGF and PlGF serum levels at 12–13 weeks were lower, when compared to those in patients who did not develop pathology (p < 0.05), and the levels of serum endocan-1 and IL-6 were higher in comparison with those in individuals who did not develop pathology (p < 0.05). Using multiple regression analysis, we obtained the regression equation (formula), which predicts the development of placental insufficiency in women of different somatotypes.

Conclusion. The resulting formula allows us to accurately predict the development of placental insufficiency and to form high-risk groups among women for the development of this disease. This will contribute to the effective implementation of therapeutic and preventive measures to avert the development of this pathology.

Journal of obstetrics and women's diseases. 2020;69(4):23-28
Pneumonia in pregnant women with COVID-19: is it a new thrombotic microangiopathy in obstetric practice?
Zazerskaya I.E., Bezhenar V.F., Godzoyeva A.O., Ishkarayeva V.V.

Thrombotic microangiopathies during pregnancy and puerperium are rare and, if undiagnosed, can be life-threating conditions for both the mother and the baby. The aim of this review article is to briefly describe clinical profile and highlight the clues for a correct diagnosis of pregnancy-related thrombotic microangiopathies. Of particular interest and important practical significance are the presented data on changes in the hemostatic system in patients with a new coronavirus infection COVID-19 through the prism of thrombotic microangiopathies.

Journal of obstetrics and women's diseases. 2020;69(4):29-40
The role of intestinal microbiota in the development of complications in pregnant women with gestational diabetes
Zinina T.A., Tiselko A.V., Yarmolinskaya M.I.

Gestational diabetes mellitus (GDM) has been declared as one of the pandemics of our time and its prevalence is 5–20% in the European population. It causes the search for new pathogenetic risk factors in order to develop effective measures for the prevention and treatment of this disease. The intestinal microbiota plays an important role in maintaining the basic functions in the human body — metabolic, protective and trophic, and it undergoes significant changes during pregnancy. It has now been proven that dysbiosis alters intestinal metabolism and can lead to the development of diabetes. The direct relationships between intestinal microflora species and circulating levels of insulin, triglycerides and very-low-density lipoproteins were found. In a number of studies, associations of various concentrations of intestinal microbiota metabolites with the probability of developing GDM were analyzed. Studies conducted in a group of women with complicated pregnancy revealed changes in the diversity and structure of the intestinal microbiota in women with preeclampsia and arterial hypertension. Therefore, all authors emphasize the need for studies that expand our understanding of the relationship of various intestinal microbiota disorders with the risk of developing GDM and its specific progressing.

Journal of obstetrics and women's diseases. 2020;69(4):41-50
Current views on overweight and obesity influence on assisted reproductive technology data
Makhmadaliyeva M.R., Gzgzyan A.M.

This article reviews the literature data on the mechanisms of the obesity effect on the in vitro fertilization (IVF) clinical efficacy and discusses the main directions of improving assisted reproductive technology data for overweight women. It was noted that the multi-level effect of obesity is manifested by a decrease in the frequency of clinical pregnancy with IVF, these women having a higher frequency of pregnancy complications, with, in particular, the risk of spontaneous miscarriages increased. It is believed that such disorders are associated with changes in the morphology of oocytes and embryos in this category of patients, as well as with impaired endometrial receptivity. A number of studies have shown that achieving normal body weight through lifestyle modifications that include healthy eating and exercise for several months before and during the IVF program and contribute to gradual and sustained weight loss can significantly improve the assisted reproductive technology outcomes.

Journal of obstetrics and women's diseases. 2020;69(4):51-59
Oxidative stress in HIV infection and its effects on the female reproductive system and pregnancy
Nikitina O.A., Maryanyan A.Y., Kolesnikova L.I.

The epidemic situation of HIV infection in the world today remains extremely difficult. In recent years, the virus has been increasingly affecting the so-called prosperous segments of the population. This is confirmed by the increase in the percentage of heterosexual transmission. Thus, in 2019, almost 60% of HIV infections were associated with this type of transmission. The determination of possible differences in the course of the infection by gender has been of interest to researchers from the very beginning of the epidemic. Undoubtedly, there should be differences in the course of the disease in men and women, especially taking into account pregnancy and childbirth in women, and this is the subject of numerous studies in various countries. In the world medical literature, the clinical course of the disease is adequately covered. However, at present, little is known about lipid peroxidation and the activity of the antioxidant blood system in HIV patients, including pregnant women. This article presents a review of the current state of the problem and analyzes studies of free radical oxidation in HIV-infected people. This study was aimed at the analysis and discussion of data on free radical and antioxidant system activities in HIV-infected people, including pregnant women.

Journal of obstetrics and women's diseases. 2020;69(4):61-72
Pathogenesis of adenomyosis
Orekhova E.K.

Adenomyosis is a common benign condition, often diagnosed in women of reproductive age with dysmenorrhea and polymenorrhea, miscarriage and infertility. Previously, it was believed that the pathological process was associated with intrauterine interventions, parturition or endometriosis diagnosed by histological examination as the gold standard. Currently, adenomyosis is perceived as an independent disease, the etiology and pathogenesis of which are based on complex molecular, genomic and immune processes, also occurring in women without a burdened maternal obstetric and gynecological history. Modern non-invasive diagnostic methods, such as ultrasonography and magnetic resonance imaging, have high sensitivity and specificity and are successfully used for diagnosis of adenomyosis. One of the main initial morphological and functional signs of the disease is a change in the so-called J-zone (junctional zone, JZ), which is the transitional part of the myometrium. Its subendometrial layer has unique structural organization, immunohistochemical structure and functional activity, which remains not fully understood. Data on the effect of adenomyosis on the course and outcome of pregnancy are mixed. This article presents a literature review of world studies on the etiology, pathogenesis and diagnosis of adenomyosis and its effect on fertility.

Journal of obstetrics and women's diseases. 2020;69(4):73-82
Trends in safe infertility treatment with assisted reproductive technologies
Paskar S.S., Kalugina A.S., Tkachuk A.G.

The expansion of indications for assisted reproductive technology has led to significant implications for assisted reproductive technology (ART) programs worldwide. More than 7 million children in the world were born using ART. Modern clinical practice in the field of reproductive sciences is aimed not only at increasing the effectiveness, but also at the safety of treatment. ART, like any other type of therapy, may be combined with negative side effects. Both the correct prediction of the risks associated with treatment and a personalized approach ensure the absolute safety of infertility treatment using in vitro fertilization. In this regard, over the past decade, a number of new research approaches have been noted that use ART methods integrated into clinical practice: cycle segmentation with subsequent embryo transfer and the elective transfer of one embryo. New approaches provide a control in relation to ovarian stimulation and a reduction in the number of transferred embryos, which helps to minimize primarily adverse perinatal outcomes. Predicting the risks and outcomes of treatment using mathematical modeling is the application of good clinical practice.

Journal of obstetrics and women's diseases. 2020;69(4):83-88
Options for generating polycystic ovary syndrome based on experimental findings in animal models
Yarmolinskaya M.I., Abashova E.I., Bulgakova O.L.

Polycystic ovary syndrome (PCOS) is a common endocrine pathology that affects 8–14% of women of reproductive age. The leading signs of the disease are hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. Over the past decades, a variety of animal models have been developed to study the etiology and pathogenesis of PCOS, including chemical, hormonal, and genetic interventions. However, a large number of experimental techniques differ even in the framework of a single model. In this review article, we summarized PCOS animal models using both direct hormonal effects and indirect methods.

Journal of obstetrics and women's diseases. 2020;69(4):89-100
Theory and Practice
Postoperative scar endometriosis (clinical observation)
Bezhenar V.F., Arakelyan B.V., Linde V.A., Kuznetsova I.A., Tatatrova N.A., Azhimova S.M., Derii E.K., Voskresenskaya Y.L.

A clinical observation of endometrioid infiltrate of a postoperative scar formed as a result of surgical delivery by cesarean section is presented in this article.

Journal of obstetrics and women's diseases. 2020;69(4):101-106

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