Processes of free redical oxidation in placenta at premature labor

Abstract

Objective. To elucidate the importance of free radical processes in the mechanism of pathogenesis of premature delivery.

Full Text

Methods. The intensity of processes of free radical oxidation (FRO) was estimated by chemiluminometric method in human placental tissues.

Results. In premature labor at 28-36 weeks of pregnancy an increase of chemiluminescence (Chi) intensity was observed which was accompanied by a rise of TBA-reactive products and by invariable level of modified proteins and a size of middle molecules. The addition of superoxide dismutase (SOD) causes a decrease of the Chi intensity in the norm and in the premature labor. Sodium azide and methionine (inhibitors of SOD - independent generation of oxygen active forms) exert weaker suppression of Chi in placental of women with premature labor then in the norm. The quantity of I₅₀ taurine and uric acid in noncomplicated term labor is higher than in preterm ones.

Conclusion. In later premature labor there is anjncrease of FRO processes mainly conditioned by the lipid peroxidation. FRO in the placenta can be realized both by SOD-dependent and SOD-independent mechanism (anion-hypochloride formation), the latter is noted to be inhibited which leads to the weakening of antibacterial barrier between mother and fetus.