Antigonadotropic effect of high doses cyproterone acetate

Abstract

Objective. To study the therapeutic effect of antiandrogenic preparation Androcur (cyproterone acetate) in patients with severe hirsutism.

Full Text

Methods. FSH, LH and testosterone levels were determined in blood of 36patients. Androcur containing 10 and 50 mg cyproterone acetate (CA) was used for the treatment.

Results. A significant decrease of FSH, LH and testosterone blood levels was observed as soon as in 3 months of using 50-100 mg of CA, while CA in a dose of 10 mg resulted in a significant decrease of FSH, LH levels only after 6-month treatment. Antigonadotropic and antiandrogenic effects developed earlier and were more pronounced at the dose of CA 50-100 mg, and after 9 moths of treatment LH levels decreased from 6.8±1.6 to 0.3±0. ILU/l (p<0.001). At the same time no reliable differences were found in the hirsutism dynamics in both groups of patients.

Conclusion. The rise of CA dose is followed by the increase of antigonadotropic and antiandrogenic effect of Androcur. High doses (50-100 mg) CA are advisable to be used in cases of severe hyperandrogenemy and patients with polycistic ovary syndrome.