Циркадный ритм матери и его значение для здоровья потомства

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Аннотация

В обзоре представлены данные о структуре циркадной системы организма и ее уникальной реорганизации при наступлении беременности. Циркадная система играет фундаментальную роль в поддержании материнского гомеостаза и создании оптимальных условий для осуществления генетической программы развития плода. Описаны механизмы защитного влияния циркадного ритма материнского мелатонина — основного мессенджера биоритмов. Рассмотрены механизмы и последствия нарушений материнской циркадианной адаптации у беременных женщин при воздействии неблагоприятных условий окружающей среды (работы в ночное время, стресса, нерегулярного питания и др.) и заболеваний, обусловленных хронодеструкцией (ожирения, сахарного диабета и др.). Выяснение состояния циркадной системы организма женщины, в частности, наличия суточного ритма продукции мелатонина, определит новый подход к оценке риска и профилактике сердечно-сосудистых, метаболических, нейроэндокринных и психических расстройств у потомства.

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Инна Ивановна Евсюкова

Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта

Автор, ответственный за переписку.
Email: eevs@yandex.ru
ORCID iD: 0000-0003-4456-2198

д-р мед. наук, профессор

Россия, 199034, Санкт-Петербург, Менделеевская линия, д. 3

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