Current views on overweight and obesity influence on assisted reproductive technology data

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Abstract

This article reviews the literature data on the mechanisms of the obesity effect on the in vitro fertilization (IVF) clinical efficacy and discusses the main directions of improving assisted reproductive technology data for overweight women. It was noted that the multi-level effect of obesity is manifested by a decrease in the frequency of clinical pregnancy with IVF, these women having a higher frequency of pregnancy complications, with, in particular, the risk of spontaneous miscarriages increased. It is believed that such disorders are associated with changes in the morphology of oocytes and embryos in this category of patients, as well as with impaired endometrial receptivity. A number of studies have shown that achieving normal body weight through lifestyle modifications that include healthy eating and exercise for several months before and during the IVF program and contribute to gradual and sustained weight loss can significantly improve the assisted reproductive technology outcomes.

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About the authors

Manizha R. Makhmadaliyeva

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

Author for correspondence.
Email: 2563737@mail.ru

MD. The Assisted Reproduction Technology Department

Russian Federation, Saint Petersburg

Alexander M. Gzgzyan

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State University

Email: agzgzyan@hotmail.com

MD, PhD, DSci (Medicine), Head of the Assisted Reproduction Technology Department; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, the Faculty of Medicine

Russian Federation, Saint Petersburg

References

  1. Kasum M, Orešković S, Čehić E, et al. The role of female obesity on in vitro fertilization outcomes. Gynecol Endocrinol. 2018;34(3):184-188. https://doi.org/10.1080/09513590.2017.1391209.
  2. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2014;384(9945):766-781. https://doi.org/10.1016/S0140-6736(14)60460-8.
  3. Luke B. Adverse effects of female obesity and interaction with race on reproductive potential. Fertil Steril. 2017;107(4):868-877. https://doi.org/10.1016/j.fertnstert. 2017.02.114.
  4. Здравоохранение в России 2019. Статистический сборник. – М.: Росстат; 2019. – 170 с. [Zdravookhranenie v Rossii. 2019. Statisticheskii sbornik. Moscow: Rosstat; 2019. 170 p. (In Russ.)]
  5. Silvestrim RL, Bos-Mikich A, Kulmann MI, Frantz N. The effects of overweight and obesity on assisted reproduction technology outcomes. JBRA Assist Reprod. 2019;23(3):281-286. https://doi.org/10.5935/1518-0557.20190005.
  6. Hruby A, Hu FB. The epidemiology of obesity: A big picture. Pharmacoeconomics. 2015;33(7):673-689. https://doi.org/10.1007/s40273-014-0243-x.
  7. Махмадалиева М.Р., Коган И.Ю., Ниаури Д.А., и др. Влияние избытка массы тела и ожирения на эффективность программ вспомогательных репродуктивных технологий // Журнал акушерства и женских болезней. – 2018. – Т. 67. – № 2. – С. 32–39. [Makhmadalieva MR, Kogan IYu, Niauri DA, et al. The effect of excess body weight and obesity on the effectiveness of assisted reproductive technologies programs. Journal of obstetrics and women’s diseases. 2018;67(2):32-39. (In Russ.)]. https://doi.org/10.17816/JOWD67232-39.
  8. MacKenna A, Schwarze JE, Crosby JA, Zegers-Hochschild F. Outcome of assisted reproductive technology in overweight and obese women. JBRA Assist Reprod. 2017;21(2):79-83. https://doi.org/10.5935/1518-0557.20170020.
  9. Bou Nemer L, Shi H, Carr BR, et al. Effect of body weight on metabolic hormones and fatty acid metabolism in follicular fluid of women undergoing in vitro fertilization: A pilot study. Reprod Sci. 2019;26(3):404-411. https://doi.org/10.1177/1933719118776787.
  10. Becker GF, Passos EP, Moulin CC. Short-term effects of a hypocaloric diet with low glycemic index and low glycemic load on body adiposity, metabolic variables, ghrelin, leptin, and pregnancy rate in overweight and obese infertile women: a randomized controlled trial. Am J Clin Nutr. 2015;102(6):1365-1372. https://doi.org/10.3945/ajcn.115.117200.
  11. Tortoriello DV, McMinn J, Chua SC. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology. 2004;145(3):1238-1247. https://doi.org/10.1210/en.2003-1406.
  12. Woodruff TK, Shea LD. A new hypothesis regarding ovarian follicle development: Ovarian rigidity as a regulator of selection and health. J Assist Reprod Genet. 2011;28(1):3-6. https://doi.org/10.1007/s10815-010-9478-4.
  13. Robker RL, Akison LK, Bennett BD, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. https://doi.org/10.1210/jc.2008-2648.
  14. Bellver J, Martínez-Conejero JA, Labarta E, et al. Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome. Fertil Steril. 2011;95(7):2335-2341.e23418. https://doi.org/10.1016/j.fertnstert.2011.03.021.
  15. Jungheim ES, Travieso JL, Hopeman MM. Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev. 2013;71Suppl 1(01):S3-S8. https://doi.org/10.1111/nure.12056.
  16. Broughton DE, Moley KH. Obesity and female infertility: Potential mediators of obesity’s impact. Fertil Steril. 2017;107(4):840-847. https://doi.org/10.1016/j.fertnstert. 2017.01.017.
  17. Klenov VE, Jungheim ES. Obesity and reproductive function: A review of the evidence. Curr Opin Obstet Gynecol. 2014;26(6):455-460. https://doi.org/10.1097/GCO. 0000000000000113.
  18. Boots CE, Bernardi LA, Stephenson MD. Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss. Fertil Steril. 2014;102(2):455-459. https://doi.org/10.1016/j.fertnstert.2014.05.005.
  19. Kawwass JF, Kulkarni AD, Hipp HS, et al. Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States. Fertil Steril. 2016;106(7):1742-1750. https://doi.org/10.1016/j.fertnstert.2016.08.028.
  20. Bailey AP, Hawkins LK, Missmer SA, et al. Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome. Am J Obstet Gynecol. 2014;211(2):163.e1-6. https://doi.org/10.1016/ j.ajog.2014.03.035.
  21. Maheswari A, Stofberg L, Bhattachaya S. Effect of overweight and obesity on asssisted reproductive technology – a systematic review. Hum Reprod Update. 2007;13(5):433-444. https://doi.org/10.1093/humupd/dmm017.
  22. Schliep KC, Mumford SL, Ahrens KA, et al. Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization. Fertil Steril. 2015;103(2):388-395. https://doi.org/10.1016/j.fertnstert.2014.10.048.
  23. Friedler S, Cohen O, Liberty G, et al. Should high BMI be a reason for IVF treatment denial? Gynecol Endocrinol. 2017;33(11):853-856. https://doi.org/10.1080/09513590. 2017.1327042.
  24. Jungheim ES, Lanzendorf SE, Odem RR, et al. Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome. Fertil Steril. 2009;92(1):256-261. https://doi.org/10.1016/j.fertnstert.2008.04.063.
  25. Luke B, Brown MB, Missmer SA, et al. Society for Assisted Reproductive Technology writing group. The effect of increasing obesity on the response to and outcome of assisted reproductive technology: A national study. Fertil Steril. 2011;96(4):820-825. https://doi.org/10.1016/j.fertnstert.2011.07.1100.
  26. Jungheim ES, Moley KH. Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol. 2010;203(6):525-530. https://doi.org/10.1016/j.ajog.2010. 06.043.
  27. Banker M, Sorathiya D, Shah S. Effect of body mass index on the outcome of in vitro fertilization/intracytoplasmic sperm injection in women. J Hum Reprod Sci. 2017;10(1):37-43. https://doi.org/10.4103/jhrs.JHRS_75_16.
  28. Souter I, Baltagi LM, Kuleta D, et al. Women, weight, and fertility: The effect of body mass index on the outcome of superovulation/intrauterine insemination cycles. Fertil Steril. 2011;95(3):1042-1047. https://doi.org/10.1016/j.fertnstert.2010.11.062.
  29. Rittenberg V, Seshadri S, Sunkara SK, et al. Effect of body mass index on IVF treatment outcome: An updated systematic review and metaanalysis. Reprod Biomed Online. 2011;23(4):421-439. https://doi.org/10.1016/ j.rbmo.2011.06.018.
  30. Provost MP, Acharya KS, Acharya CR, et al. Pregnancy outcomes decline with increasing body mass index: Analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for assisted reproductive technology registry. Fertil Steril. 2016;105(3):663-669. https://doi.org/10.1016/j.fertnstert.2015.11.008.
  31. Atzmon Y, Shoshan-Karchovsky E, Michaeli M, et al. Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles – a prospective study. J Assist Reprod Genet. 2017;34(9):1145-1151. https://doi.org/10.1007/s10815-017-0975-6.
  32. Espinós JJ, Polo A, Sánchez-Hernández J, et al. Weight decrease improves live birth rates in obese women undergoing IVF: A pilot study. Reprod Biomed Online. 2017;35(4):417-424. https://doi.org/10.1016/j.rbmo.2017. 06.019.
  33. Milone M, Sosa Fernandez LM, Sosa Fernandez LV, et al. Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile women? Obes Surg. 2017;27(8):2106-2112. https://doi.org/10.1007/s11695-017-2614-9.
  34. Jungheim ES, Moley KH. Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol. 2010;203(6):525-530. https://doi.org/10.1016/j.ajog.2010. 06.043.
  35. Machtinger R, Combelles CM, Missmer SA, et al. The association between severe obesity and characteristics of failed fertilized oocytes. Hum Reprod. 2012;27(11):3198-3207. https://doi.org/10.1093/humrep/des308.
  36. Jungheim ES, Macones GA, Odem RR, et al. Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril. 2011;95(6):1970-1974. https://doi.org/10.1016/ j.fertnstert.2011.01.154.
  37. Sarais V, Pagliardini L, Rebonato G, et al. Comprehensive analysis of body mass index effect on in vitro fertilization outcomes. Nutrients. 2016;8(3):109. https://doi.org/10.3390/nu8030109.
  38. Zhang JJ, Feret M, Chang L, et al. Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF. Gynecol Endocrinol. 2015;31(5):409-413. https://doi.org/10.3109/09513590.2015.1014785.
  39. Leary C, Leese HJ, Sturmey RG. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod. 2015;30(1):122-132. https://doi.org/10.1093/humrep/deu276.
  40. Robker RL, Akison LK, Bennett BD, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94(5):1533-1540. https://doi.org/10.1210/jc.2008-2648.
  41. Comstock IA, Kim S, Behr B, Lathi RB. Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization. J Assist Reprod Genet. 2015; 32(9):1299-1304. https://doi.org/10.1007/s10815-015-0515-1.
  42. Coyne K, Whigham LD, O’Leary K, et al. Gestational carrier BMI and reproductive, fetal and neonatal outcomes: Are the risks the same with increasing obesity? Int J Obes (Lond). 2016;40(1):171-175. https://doi.org/10.1038/ijo. 2015.159.
  43. Bellver J, Pellicer A, Garcıa-Velasco JA, et al. Obesity reduces uterine receptivity: Clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril. 2013;100(4):1050-1058. https://doi.org/10.1016/ j.fertnstert.2013.06.001.
  44. Rhee JS, Saben JL, Mayer AL, et al. Diet-induced obesity impairs endometrial stromal cell decidualization: A potential role for impaired autophagy. Hum Reprod. 2016;31(6):1315-1326. https://doi.org/10.1093/humrep/dew048.
  45. Turner-McGrievy GM, Grant BL. Prevalence of body mass index and body weight cut-off points for in vitro fertilization treatment at U.S. clinics and current clinic weight loss strategy recommendations. Hum Fertil (Camb). 2015;18(3):215-219. https://doi.org/10.3109/14647273.2015.1022606.
  46. Meldrum DR. Introduction: Obesity and reproduction. Fertil Steril. 2017;107(4):831-832. https://doi.org/10.1016/ j.fertnstert.2017.02.110.
  47. Sim KA, Partridge SR, Sainsbury A. Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review. Obes Rev. 2014;15(10):839-850. https://doi.org/10.1111/obr.12217.
  48. Islam MA, Alam F, Solayman M, et al Dietary phytochemicals: Natural swords combating inflammation and oxidation-mediated degenerative diseases. Oxid Med Cell Longev. 2016;2016:5137431. https://doi.org/10.1155/2016/5137431.
  49. Juanola-Falgarona M, Salas-Salvadó J, Ibarrola-Jurado N, et al. Effect of the glycemic index of the diet on weight loss, modulation of satiety, inflammation, and other metabolic risk factors: A randomized controlled trial. Am J Clin Nutr. 2014;100(1):27-35. https://doi.org/10.3945/ajcn.113.081216.
  50. Palomba S, Falbo A, Valli B, et al. Physical activity before IVF and ICSI cycles in infertile obese women: An observational cohort study. Reprod Biomed Online. 2014;29(1):72-79. https://doi.org/10.1016/j.rbmo.2014.03.006.

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Copyright (c) 2020 Makhmadaliyeva M.R., Gzgzyan A.M.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 66759 от 08.08.2016 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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