Changes in parameters of platelet-vessel haemostasis in pregnants with insulin dependent diabetes mellitus (IDDM)

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Objective: To study the parameters of platelet-vessel link of haemostasis in pregnants with IDDM.

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Methods: We examined 315 women, from them 130 pregnants with various gestational ages, suffering IDDM. We defined: platelet aggregation by photometring of plasma, level of von Willebrand factor (vWf) by indirect immunofermental analysis and calculation of quantity of circulating endothelial cells in blood by phaso-contrast microscopy. Results of research were processed by a method of variational statistic and by means of the correlation analysis.

Results: Speed and intensity of platelet aggregation in the patients with IDDM were increasing via progressing of gestation, and were higher than in healthy pregnants. The greatest platelet activity was observed at pregnants with expressed diabetic retino-and nephropathia. In pregnants with IDDM both markers of endothelial disfunction, quantity of circulating endothelial cells and vWf showed significant increase of their level in process of growth of gestation and in comparison with healthy pregnants. These markers were authentically connected with increasing of duration of diabetes, manifesting of diabetic vascular complications and severity of accompanying gestosis.

Conclusions: The found out changes in parameters of platelet-vessel haemostasis in pregnants with IDDM show their undoubtedly important role in pathogenesis of progressing of diabetic vascular complications and development of gestosis.