Hormonal analysis of the menstrual cycle among infertile women with ovarian endometriosis

Abstract

Aim: The main aim of the study was hormonal analysis of the menstrual cycle among infertile women with endometriosis.

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Method: 60 infertile women with ovarian endometriosis (single implants and endometriomas) were analyzed. We evaluated serum levels of 17-b Estradiol and Progesteron measured in 21 day of the menstrual cycle. Clinical stage of endometriosis were estimated based on American Fertility Society Classification (AFS).

Results: 1. We observed that significantly more patients presented advanced endometriosis - stage III and IV (according to AFS), respectively 15 and 27 women. Minimal and mild endometriosis were diagnosed in 18 women - stage I and stage II, respectively 11 and 7 patients. 2. Mean level of 17-b Estradiol among all patients was higher than normal (257,6 ± 124,0 pg/ml) but women with more advanced endometriosis (stage III and IV) presented statistically higher level of this hormone. 3. The mean level of Progesterone was low (3,26 ± 1,94 ng/ml). We did not observe any difference in serum concentration of this hormone between compared groups.

Conclusion: The mean serum level of 17-b Estradiol was significantly higher among patient with more advanced endometriosis.