Permeability of erythrocyte membranes and sorption abilities of erythrocytes in neonates, born in asphyxia

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Objective: To study features of a permeability of erythrocyte membranes and sorption ability of erythrocytes in neonates, born in asphyxia.

全文:

Methods: 13 mature neonates, born in asphyxia, were investigated during the first 4-12 hours of life. A group of comparison consisted of 12 healthy mature neonates. Permeability of erythrocyte membranes (PEM) was assessed by means of estimation of percent of hemolyzed erythrocytes in 7 solutions with different ureal dilution (V.N. Kolmakov, 1982). Sorption ability (SAE) was investigated by the method of adsorption of methylen blue by erythrocytes (A.A. Togaybayev, 1988).

Results: PEM in healthy mature neonates — 10.97 ± 2.6%, SAE — 54.3 ± 2.8%. Three types of PEM in neonates, born in asphyxia were revealed. First - normal values of PEM (13.2 ± 1.2%), p>0.05 in mild degree of disturbance of a cerebral circulation. Second — high parameters of PEM (32.5 ± 6.7%, p=0.02) in moderate degree of disturbance of cerebral circulation. Third — normal parameters of PEM (13.5 ± 2.5%, p>0.05) at serious disturbance of cerebral circulation. The third variant could be seen in combination of chronic and acute hypoxia and characterized with steady perinatal pathology of CNS. SAE in neonates, born in asphyxia — 46.9 ± 3.1%, p>0.05.

Conclusion: Assessment of PEM in neonates, born in asphyxia is a diagnostic criterion of seriousness of intrauterine fetal distress.