Correction of pathologic changes in the system of antioxidant protection in pregnants with pyelonephritis

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Objective. The purpose of the present work was to reveal changes in the system of antioxi-dant protection in pregnant women with pyelonephritis and clinical features of current pregnancy in conditions of antioxidant therapy (unithiol, ascorbinic acid, tocoferol acetat).

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Methods. 30 pregnant women with chronic and gestational pyelonephritis were examined. Standart clinical, biochemical, bacteriological methods of research were used. The estimation of biochemical parameters of nonfermentative and fermentative parts of antioxidant system were made with a simultaneous estimation of indices of free - radical oxidation. Statistical reliability was determined by methods of variational statistic with the use of Stydent criterion.

Results. The analysis of influence of antioxdant therapy on duration of pyelonephritis at pregnants has revealed authentic decrease of terms of hospitalization, strengthening the effect of rutine treatment and both better outcome of labour and the course of postpartum period.