The influence of fertility proteins upon lymphocyte activation in decidua

Abstract

Objective: The aim of the present work was to investigate the effect of pregnancy proteins SP-I and aMGF upon parameters of activation of decidual lymphoid cells in normal pregnancy and gestosis.

Full Text

Method: The expression of activation markers by decidual lymphocytes of II women with normal and 10 women with gestosis was examined by flow cytomerty.

Results: It was found, that in normal pregnancy SP-I increased the expression of CD95 and decreased the expression of CD71 molecules and HLA-DR antigens. In gestosis pregnancy it diminished the expression of CD71, but enhanced the amount of HLA-DR-positive lymphocytes in decidua. Contrary to that, SAMG- 2 in normal pregnancy elevated the number of CD25+ and CDIIb+ decidual lymphocytes, but in women with gestosis it down regulated the expression of CD71 and CDIIb molecules.

Conclusions: Thus, it can be supposed that at local level SP-I in normal pregnancy suppressed the late stages of cell activation and enhanced apoptosis processes, while in gestosis it impaired both steps of lymphocyte activation in decidua. From the other hand, SAMG-2 in normal pregnancy induced cell cooperation and decreased it in gestosis pregnancy.