Immunologic factors of spontaneous abortion

Abstract

Objective. The purpose of the study was to researches of contents\affinities autoantibodies (a-AB) of IgG class, which pass placenta barrier freely in blood of woman suffering from habitual miscarriages.

Full Text

Objective. The purpose of the study was to researche of contents/affinities autoantibodies (a-AB) of IgG class, which pass placenta barrier freely in blood of woman suffering from habitual miscarriages.

Materials. A total of 221 women aged 20 to 38 yeas were examined after spontaneous abortion.

Methods. Evaluation of a-AB level to developmentally important proteins ACBP and MP-65 in women blood by ELI-P method, general clinical examination, ultrasonography of pelvic organs, bacteriological analysis of discharge from the cervix uteri, hormonal examination, analysis of immunological state, genetic examination and hystologycal analysis of the abrasion cave uteri materials after missed abortion.

Results. More then 95% of women had abnormally high level of a-AB. Infectious agents, endocrine pathology, immune disorders influence the level of a-AB differently. The highest level had women with combination some pathogenic factors. The level of a-AB was decreasing after the correct treatment.

Conclusions. Contents/affinities of a-AB to developmentally important proteins ACBP and MP-65 in women blood is an important characteristic of women reproductive system.