About significance of the endotelial dysfunction indicators in evaluation of the condition of intrauterine fetus in toxemia of pregnancy

Abstract

Objective: The aim of the present research was the verification of the dependence between of indicates of the intrauterine fetuses state and the marks of mothers endothelial dysfunction.

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Methods: As the marks of the endothelial dysfunction in pregnant women was taken the number of circulating endoteliocytes, von Willebrand factor, tissular stimulator of plasminogen. The presence of hypoxia and fetal grow retardation was revealed by means of ultrasonography and Doppler analysis of maternal-fetal circulation. We studied 185 pregnant women with toxemia of pregnancy in various degrees.

Results: The results of the information processing of the data mode by tracing regressive analysis showed that possessing the indicators intravascular - platelet hemostasis of the pregnant women one can predict the presence of hypoxia and fetal growth retardation in following equations: Y=-0,6-0,003X1-0,01X2, where Y - hypoxia of fetus, X1 — von Willebrand factor (%) and X2 - presence of endotheliocytes in circulation (N/ml). Apgar’s score in the first minute after delivery corresponds to the equation: Y=7,64-0,018X1, in the fifth minute - Y=8,16-0,014X1, where X1 - is the number of circulating endoteliocytes.

Conclusions: The disturbance of maternal-fetal circulation the development of toxemia of pregnancy is caused to a considerable degree by the endothelial dysfunction.