Extended combined screening for preeclampsia prediction in women with diabetes mellitus
- 作者: Kapustin R.V.1,2, Tcybuk E.M.2, Kopteeva E.V.1, Alekseenkova E.N.1, Chepanov S.V.1, Shelaeva E.V.1, Arzhanova O.N.1,2, Korenevsky A.V.3, Kogan I.Y.1,2
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- St. Petersburg State University
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- 期: 卷 72, 编号 2 (2023)
- 页面: 39-50
- 栏目: Original Research
- ##submission.dateSubmitted##: 13.03.2023
- ##submission.dateAccepted##: 04.04.2023
- ##submission.datePublished##: 18.05.2023
- URL: https://journals.eco-vector.com/jowd/article/view/321321
- DOI: https://doi.org/10.17816/JOWD321321
- ID: 321321
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BACKGROUND: Early screening for preeclampsia has shown high efficiency for low-risk groups, however, the presence of systemic vascular disease in patients with diabetes mellitus complicates their use and requires the development of additional approaches to predicting preeclampsia in this group of patients.
AIM: The aim of this study was to evaluate the effectiveness of early prediction of preeclampsia with extended combined screening in patients with pregestational types of diabetes mellitus.
MATERIALS AND METHODS: This study included 75 pregnant women: 40 patients with type 1 diabetes mellitus, and 35 patients with type 2 diabetes mellitus. To determine the risk of further preeclampsia development, we evaluated biochemical, biophysical and anamnestic factors, along with the serum levels of placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin at 11+0 to 13+6 gestational weeks. The main outcome assessed was the development of preeclampsia.
RESULTS: In patients with further development of preeclampsia (35% in type 1 and 40 % in type 2 diabetic women), we observed higher soluble fms-like tyrosine kinase 1 / placental growth factor ratios, as well as elevated serum soluble endoglin (type 1 diabetes mellitus) and soluble fms-like tyrosine kinase 1 (type 2 diabetes mellitus) levels. Isolated determination of placental growth factor showed no significant differences in the levels of this angiogenic factor in preeclampsia. A multivariate predictive model for preeclampsia demonstrated high prognostic parameters: for patients with type 1 diabetes mellitus, area under the curve was 0.96 (95% confidence interval 0.93–1.00), with positive predictive value 76.7% and negative predictive value 90.1%; for patients with type 2 diabetes mellitus, area under the curve was 0.94 (95% confidence interval 0.86–1.00), with positive predictive value 88.5% and negative predictive value 97.1%.
CONCLUSIONS: Specific biochemical and biophysical markers of preeclampsia combined with maternal risk factors and assessment of carbohydrate metabolism can increase the predictive value of early screening studies for preeclampsia in women with pregestational diabetes mellitus.
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作者简介
Roman Kapustin
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; St. Petersburg State University
编辑信件的主要联系方式.
Email: kapustinroman@gmail.com
ORCID iD: 0000-0002-2783-3032
SPIN 代码: 7300-6260
Scopus 作者 ID: 57191964826
Researcher ID: G-3759-2015
MD, Dr. Sci. (Med.)
俄罗斯联邦, Saint Petersburg; Saint PetersburgElizaveta Tcybuk
St. Petersburg State University
Email: elizavetatcybuk@gmail.com
ORCID iD: 0000-0001-5803-1668
SPIN 代码: 3466-7910
Researcher ID: ABB-6930-2020
俄罗斯联邦, Saint Petersburg
Ekaterina Kopteeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ekaterina_kopteeva@bk.ru
ORCID iD: 0000-0002-9328-8909
SPIN 代码: 9421-6407
Scopus 作者 ID: 57219285002
俄罗斯联邦, Saint Petersburg
Elena Alekseenkova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ealekseva@gmail.com
ORCID iD: 0000-0002-0642-7924
SPIN 代码: 3976-2540
Scopus 作者 ID: 57212242446
Researcher ID: W-3735-2017
俄罗斯联邦, Saint Petersburg
Sergey Chepanov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: chepanovsv@gmail.com
ORCID iD: 0000-0001-6087-7152
SPIN 代码: 6642-6837
Scopus 作者 ID: 56399329700
Researcher ID: M-3471-2015
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgElizaveta Shelaeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: eshelaeva@yandex.ru
ORCID iD: 0000-0002-9608-467X
SPIN 代码: 7440-0555
Researcher ID: K-2755-2018
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgOlga Arzhanova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; St. Petersburg State University
Email: arjanova_olga@mail.ru
ORCID iD: 0000-0003-3059-9811
SPIN 代码: 7910-6039
Researcher ID: G-6895-2015
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Saint Petersburg; Saint PetersburgAndrey Korenevsky
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: a.korenevsky@yandex.ru
ORCID iD: 0000-0002-0365-8532
SPIN 代码: 7942-6016
Scopus 作者 ID: 16037015200
Researcher ID: K-3444-2013
Dr. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgIgor Kogan
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; St. Petersburg State University
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
SPIN 代码: 6572-6450
Scopus 作者 ID: 56895765600
Researcher ID: P-4357-2017
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
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