Assessment of endometrial and subendometrial three-dimensional power Doppler angiography evaluated by the VOCAL method in frozen-thawed embryo transfer cycles on hormone replacement therapy
- 作者: Safarian G.K.1, Ob'edkova K.V.1, Ryzhov J.R.1, Krikheli I.O.1, Dzhemlikhanova L.K.1, Makhmadalieva M.R.1, Mazurenko M.S.1, Tapilskaya N.I.1, Gzgzyan A.M.1, Bespalova O.N.1
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 73, 编号 3 (2024)
- 页面: 69-80
- 栏目: Original Research
- ##submission.dateSubmitted##: 03.03.2024
- ##submission.dateAccepted##: 19.04.2024
- ##submission.datePublished##: 17.07.2024
- URL: https://journals.eco-vector.com/jowd/article/view/627896
- DOI: https://doi.org/10.17816/JOWD627896
- ID: 627896
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BACKGROUND: The effectiveness of in vitro fertilization cycles / frozen-thawed embryo transfer cycles depends on a number of factors, the endometrial one being of great importance. Adequate endometrial and subendometrial blood supply is considered necessary for successful implantation. Currently, the possibilities of non-invasive assessment of the implantation properties of the endometrium are limited to the use of ultrasound.
AIM: The aim of this study was to assess the performance of endometrial and subendometrial three-dimensional power Doppler angiography combined with the Virtual Organ Computer-aided Analysis (VOCAL) method in frozen-thawed embryo transfer cycles on hormone replacement therapy and compare the obtained data among the women examined.
MATERIALS AND METHODS: This prospective study included 20 women. Doppler measurements were carried out three times — on the day of progesterone initiation, the day before embryo transfer and on the day of embryo transfer. The VOCAL software assessed the endometrial and subendometrial volume and blood flow indices such as vascularization index, flow index, and vascularization flow index. Patients were divided into two study groups depending on the onset of clinical pregnancy.
RESULTS: On the day of progesterone initiation among patients who got pregnant, we observed higher vascularization (3.52 ± 1.99 vs. 1.05 ± 1.36; p = 0.03) and vascularization flow (1.54 ± 0.98 vs. 0.63 ± 0.55; p = 0.03) indices compared to women with a negative result. Moreover, endometrial vascularization index on the day of progesterone initiation was positively correlated with the estrogen dose among both pregnant (r = 0.61; p = 0.04) and non-pregnant (r = 0.9; p = 0.0008) women. No differences in subendometrial blood flow indices depending on the onset of pregnancy were obtained, just as endometrial blood flow indices the day before embryo transfer and on the day of embryo transfer were comparable between women in the both study groups.
CONCLUSIONS: Three-dimensional power Doppler angiography evaluated by the Virtual Organ Computer-aided Analysis (VOCAL) method is a promising tool for non-invasive assessment of endometrial receptivity in frozen-thawed embryo transfer programs. However, further studies are required on a larger patient sample to form conclusions that are more accurate.
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作者简介
Galina Safarian
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: galasaf07@gmail.com
ORCID iD: 0000-0001-5988-323X
SPIN 代码: 7096-3838
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgKsenia Ob'edkova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: obedkova_ks@mail.ru
ORCID iD: 0000-0002-2056-7907
SPIN 代码: 2709-2890
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgJulian Ryzhov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: julianryzhov@gmail.com
ORCID iD: 0000-0002-5073-8279
SPIN 代码: 8320-1234
俄罗斯联邦, Saint Petersburg
Inna Krikheli
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ikrikhely@gmail.com
ORCID iD: 0000-0002-5439-1727
SPIN 代码: 7356-6189
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgLyailya Dzhemlikhanova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: dzhemlikhanova_l@mail.ru
ORCID iD: 0000-0001-6842-4430
SPIN 代码: 1691-6559
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgManizha Makhmadalieva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: 2563737@mail.ru
ORCID iD: 0000-0002-9578-8931
SPIN 代码: 1523-0196
俄罗斯联邦, Saint Petersburg
Maria Mazurenko
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mazurenko.maria@inbox.ru
ORCID iD: 0000-0002-2402-829X
SPIN 代码: 8985-3994
俄罗斯联邦, Saint Petersburg
Natalia Tapilskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: tapnatalia@yandex.ru
ORCID iD: 0000-0001-5309-0087
SPIN 代码: 3605-0413
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Saint PetersburgAlexander Gzgzyan
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: agzgzyan@mail.ru
ORCID iD: 0000-0003-3917-9493
SPIN 代码: 6412-4801
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Saint PetersburgOlesya Bespalova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: shiggerra@mail.ru
ORCID iD: 0000-0002-6542-5953
SPIN 代码: 4732-8089
MD, Dr. Sci. (Med.)
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