Functional rehabilitation of the patient with keratoconus after collagen cross-linking with modified parameters

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Abstract

This article contains a clinical case of a favorable outcome of treatment of chronic keratoconus by the collagen cross-linking with modified parameters. Possible mechanisms of action of collagen cross-linking on biomechanical and biochemical properties of the cornea are presented as well as survey data and postoperative dynamic monitoring of the patient before and after collagen cross-linking. Reasoning about new ways to perfect standard approaches with the aim of improving the results of the application of this treatment are also given.

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About the authors

Sanasar S Papayan

First Pavlov State Medical University of St Petersburg

Email: dr.papanyan@yandex.ru
MD, postgraduate research student. Ophthalmology department

Inna A Riks

First Pavlov State Medical University of St Petersburg

Email: riks0503@yandex.ru
MD, PhD, assistant professor. Ophthalmology department

Sergey A Novikov

First Pavlov State Medical University of St Petersburg

Email: novikov.phd@gmail.ru
MD, DMedSc, professor. Ophthalmology department

References

  1. Абугова Т.Д. Кератоконус: клиническая лекция для врачей и оптометристов. - СПб.: ООО РА Веко, 2015. - 94 с. [Abugova TD. Keratokonus: klinicheskaya lektsiya dlya vrachey i optometristov. Sant Petersburg: OOO «RA Veko»; 2015. 94 p. (In Russ).]
  2. Папанян С.С., Новиков С.А., и др. Результаты ретроспективного исследования коллагенового кросс-линкинга при кератоконусе на ранних стадиях заболевания // Современная оптометрия. - 2015. - № 10(90). - С. 20-24. [Papanyan SS, Novikov SA, et al. Rezul’taty retrospektivnogo issledovaniya kollagenovogo kross-linkinga pri keratokonuse na rannikh stadiyakh zabolevaniya. Sovremennaya optometriya. 2015;10(90):20-24. (In Russ).]
  3. Elbaz U, Shen C, Lichtinger A. More Accelerated (9-mW/ cm2) Corneal Collagen Crosslinking for Keratoconus-A 1 Year Follow-up. Cornea. 2014;33(8):769-773. doi: 10.1097/ICO.0000000000000154.
  4. Spoerl E, Schreiber J, Hellmund, et al. Crosslinking Effects in the Cornea of Rabbits. Ophthalmology. 2000;97:203-206.
  5. Wollensak G, Spoerl E, Seiler Th. Riboflavin/Ultraviolet-A Induced Collagen Crosslinking for the Treatment of Keratoconus. Am J Ophthalmol. 2003;135:620-627. doi: 10.1016/S0002-9394(02)02220-1.
  6. Wilson SE, Kim WG. Keratocyte Apoptosis: Implication on Corneal Wound Healing, Tissue Organization and Disease. Invest Ophthalmol Vis Sci. 1998;39:220-226.

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Copyright (c) 2016 Papayan S.S., Riks I.A., Novikov S.A.

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