A comparative analysis of the course of wet age-related macular degeneration in eyes with incipient cataract and in eyes after phacoemulsification

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Many patients with wet age-related macular degeneration (AMD) also have a cataract in the same eye. Because there is a theoretical risk of progression of the degenerative processes in the macular area after surgical lens removal, this raises some ethical, clinical and economical questions for ophthalmologists. The purpose of the study was to compare the course of wet AMD in eyes with incipient cataract and the course in eyes after surgical cataract removal. Materials and methods: 135 eyes with wet AMD, 48 eyes - treated group - were subjects to phacoemulsification during the study, 87 eyes - control group - with incipient cataract without indications for surgery. Regular visits every 1.5 months during 2 years of follow-up with visual acuity testing, central retinal thickness analysis by optical coherence tomography (OCT). Anti-VEGF injections were performed according to a PRN regimen. Results: there was no statistically significant difference in visual acuity, central retinal thickness, intravitreal injection frequency between both groups during the study period. Conclusions: No influence of phacoemulsification on the wet AMD course was found.

Yuriy Sergeyevich Astakhov

First I. P. Pavlov State Medical University of St. Petersburg

MD, doctor of medical science, professor, Department of Ophthalmology

Nikita Yur’yevich Dal’

First I. P. Pavlov State Medical University of St. Petersburg

MD, doctor of medical science, professor, head of the department of Ophthalmology

Natal’ya Viktorovna Chistyakova

First I. P. Pavlov State Medical University of St. Petersburg

Department of Ophthalmology

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