The enzymatic vitreolysis — a new trend in the treatment of retinal vein occlusions

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Abstract


Vitreoretinal relationships exert a significant influence on the course of retinal vein occlusions (RVO) and post-thrombotic retinopathy. A single intravitreal injection of Actilyse 50 mkg in the period from 1 till 21 days from the disease onset stimulates a posterior vitreous detachment in 30.4% patients with non-ischemic and 24.8% patients with the type of ischemic RVO. The process of transition from the partial posterior hyaloid detachment to the complete one, and complete posterior hyaloid detachment in patients who did not have it from the beginning, was accompanied by a visual acuity increase by a factor of 1.5. The use of enzymatic vitreolysis in patients with RVO increases the probability of reduced macular edema in the early disease period, to increases visual acuity, and decreases the risk of neovascularization development in the posterior eyeball segment.

Svetlana Nikolaevna Tultseva

I. P. Pavlov State Medical University

Email: tultceva@yandex.ru
MD, assistant professor, Department of Ophthalmology

  1. Akiba J., Quiroz M. A., Trempe C. L. Role of posterior vitreous detachment in idiopathic macular holes // Ophthalmology. — 1990. — Vol. 97(12). — P. 1610–1613;
  2. Akiba J., Kado M., Kakehashi A., Trempe C. L. Role of the vitreous in posterior segment neovascularization in central retinal vein occlusion // Ophthalmic Surg. — 1991. — Vol. 22. — P. 498–502.
  3. Krebs I., Brannath W., Glittenberg C. et al. Posterior Vitreomacular Adhesion: A Potential Risk Factor for Exudative Age-related Macular Degeneration? // Am. J. Ophthalmol. — 2007. — Vol. 144(5). — P. 741–746.
  4. Lee S. J., Lee C. S., Koh H. J. Posterior vitreomacular adhesion and risk of exudative age-related macular degeneration: paired eye study // Am. J. Ophthalmol. — 2009. — Vol. 147(4). — P. 621–626.
  5. Ophir A., Trevino A., Fatum S. Extrafoveal vitreous traction associated with diabetic diffuse macular oedema // Eye. — 2010. — Vol. 24. — P. 347–353.
  6. Ophir A., Trevino A., Martinez M. R. Extrafoveal vitreous traction associated with branch retinal vein occlusion // Eur. J. Ophthalmol. — 2010. — Vol. 20(4). — P. 733–739.
  7. Robison C. D., Krebs I., Binder S. et al. Vitreomacular adhesion in active and end-stage age-related macular degeneration // Am. J. Ophthalmol. — 2009. — Vol. 148(1). — P. 79–82.
  8. Sebag J. Anomalous posterior vitreous detachment. A unifying concept in vitreoretinal disease // Graefes Arch. Clin. Exp. Ophthalmol. — 2004. — Vol. 242. — P. 690–698.

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