Drug-induced mydriasis in infants born at different gestation terms
Dublin Core | PKP源数据项目 | 这个文档的源数据 | |
1. | 标题 | 文档的标题 | Drug-induced mydriasis in infants born at different gestation terms |
2. | 创建者 | 作者姓名,工作单位,国家 | Elvira Saidasheva; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
2. | 创建者 | 作者姓名,工作单位,国家 | Svetlana Biyanovskaya; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
2. | 创建者 | 作者姓名,工作单位,国家 | Fedor Kovshov; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
2. | 创建者 | 作者姓名,工作单位,国家 | Marina Petrachkova; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
2. | 创建者 | 作者姓名,工作单位,国家 | Olga Dolgova; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
2. | 创建者 | 作者姓名,工作单位,国家 | Yuriy Levadnev; North-Western State Medical University named after I.I. Mechnikov ; 俄罗斯联邦 |
3. | 主题 | 学科 | |
3. | 主题 | 关键词 | pupil dilation; combined mydriatic; side effects; newborns; retinopathy of prematurity |
4. | 描述 | 摘要 | Background. At the present time, the problem of choice of eye drops to achieve adequate mydriasis with minimal side effects for retinopathy of prematurity screening remains an urgent challenge. Purpose. To estimate the clinical efficacy of combination mydriatic eye drops Fenicamide in infants born at different gestation terms. Materials and methods. Under observation, there were 75 newborns (150 eyes) and babies aged from 1 day to 3 months (average, 38.2 ± 32.2 days). Patients were distributed into 3 groups depending on gestational age: group 1 consisted of 25 full-term infants; group 2 – of 25 premature babies, and group 3 – of 25 extremely preterm infants. To achieve mydriasis, 1 drop of combination eye drops (5% phenylephrine and 0.8% tropicamide) was instilled. Dynamics of pupil diameter change in each group of patients was registered within 4 hours, and side effects were recorded within 24 hours. The quality of fundus visualization was estimated using a pediatric retinal camera RetCam 3. Results. Maximal pupil dilation (average, 6.5 ± 0.5 mm) was reached to 60 ± 14 min after instillation on average; pupil remained dilated within 1 hour, its diameter became normal in 4 hours. Mydriasis varied from 5.9 mm in extremely premature infants to 7 mm in the full-term newborns (p > 0.05), and allowed a full and high quality examination of the fundus in all patients, including the visualization of peripheral zones of the retina for retinopathy of prematurity screening. It was established that drug side effects were absent in 76% (57) of infants, they were present in 24% (18) of infants, mostly as local reaction. Conclusion. Fenicamide eye drops are an effective mydriatic medication, with a convenient instillation regimen, have minimal side effects, and can be recommended for retinopathy of prematurity screening and monitoring. |
5. | 出版商 | 组织机构,地点 | Eco-Vector |
6. | 合作者 | 主管 | |
7. | 日期 | (YYYY-MM-DD) | 15.12.2018 |
8. | 类型 | 现状与流派 | 同行评议的文章 |
8. | 类型 | 类型 | 来源文章 |
9. | 格式 | 文件格式 | |
10. | 识别码 | 环球资源指标 | https://journals.eco-vector.com/ov/article/view/11127 |
10. | 识别码 | Digital Object Identifier (DOI) | 10.17816/OV11485-92 |
10. | 识别码 | Digital Object Identifier (DOI) (PDF (Rus)) | 10.17816/OV11127-8758 |
11. | 源 | 期刊/会议标题 ; 卷., 期. (年) | Ophthalmology Reports; 卷 11, 编号 4 (2018) |
12. | 语言 | English=en | ru |
13. | 关系 | 补充文件 | |
14. | 范围 | 地理位置、年代时期、调查样本(性别、年纪等等) | |
15. | 权力 | 版权及权限 |
版权所有 © Saidasheva E.I., Biyanovskaya S.V., Kovshov F.V., Petrachkova M.S., Dolgova O.S., Levadnev Y.V., 2018![]() 此作品已接受知识共享署名 4.0国际许可协议的许可 |