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Multifocal character of lesions in gunshot open globe injury type B in experiment
- Authors: Kol'bin A.A.1, Kulikov A.N.1, Zybina N.N.2, Frolova M.Y.2, Troyanovsky R.L.1, Chirskiy V.S.1
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Affiliations:
- Kirov Military Medical Academy
- Nikiforov All-Russian Center Emergency and Radiation Medicine
- Issue: Vol 17, No 2 (2024)
- Pages: 67-80
- Section: Experimental trials
- Submitted: 16.02.2024
- Accepted: 15.05.2024
- Published: 09.07.2024
- URL: https://journals.eco-vector.com/ov/article/view/627078
- DOI: https://doi.org/10.17816/OV627078
- ID: 627078
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Abstract
BACKGROUND: An increase was noted in the number of gunshot eyeball injuries, which are accompanied by low functional outcomes. Reproduction and experimental study of this type of eye injury would help improving the functional and cosmetic treatment results in patients.
AIM: The aim of the study is to investigate gunshot open globe injury type B (penetrating wound without intraocular foreign body) on a standardized experimental model.
MATERIALS AND METHODS: A complete investigation of the standardized model of gunshot open globe injury type B (penetrating wound without intraocular foreign body) simulated on the ballistic test facility was carried out. The experiment was accomplished at the ophthalmology chair on 36 rabbits (71 eyes). The injury was inflicted in the projection of the ciliary body — zone II (Birmingham Eye Trauma Terminology). The examination in the control period included ophthalmologic (ophthalmoscopy, full field electroretinography, optical coherence tomography), biochemical (testing of vitreous fibronectin level), histological and radiological (magnetic resonance imaging, ultrasound examination) methods. Statistical non-parametric methods of data analysis were used.
RESULTS: The analysis of gunshot open globe injury type B model demonstrated the rate and multiple foci of abnormalities practically of all eyeball structures.
CONCLUSIONS: For the first time ever, the characteristics of gunshot open globe injury type B model were studied using a new complex of methods, their high reproducibility (91.5–100%) was demonstrated. Based on recorded abnormalities in all ocular structures, including proliferative vitreoretinopathy, the multifocal character of damage in this type of injury is validated.
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About the authors
Aleksei A. Kol'bin
Kirov Military Medical Academy
Email: kolba81@yandex.ru
ORCID iD: 0000-0002-8305-3049
SPIN-code: 4718-5171
Russian Federation, Saint Petersburg
Aleksei N. Kulikov
Kirov Military Medical Academy
Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
SPIN-code: 6440-7706
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgNatalia N. Zybina
Nikiforov All-Russian Center Emergency and Radiation Medicine
Email: zybinan@inbox.ru
ORCID iD: 0000-0002-5422-2878
SPIN-code: 5164-2969
Dr. Sci. (Biology), Professor
Russian Federation, Saint PetersburgMilena Yu. Frolova
Nikiforov All-Russian Center Emergency and Radiation Medicine
Author for correspondence.
Email: frolusya@mail.ru
ORCID iD: 0000-0003-0917-6371
SPIN-code: 6313-1919
Cand. Sci. (Biologу)
Russian Federation, Saint PetersburgRoman L. Troyanovsky
Kirov Military Medical Academy
Email: rltroy@rambler.ru
ORCID iD: 0000-0003-1353-9358
SPIN-code: 1900-1622
MD, Dr. Sci (Medicine), Professor
Russian Federation, Saint PetersburgVadim S. Chirskiy
Kirov Military Medical Academy
Email: v-chirsky@mail.ru
ORCID iD: 0000-0002-8336-1981
SPIN-code: 7295-3369
MD, Dr. Sci. (Medicine)
Russian Federation, Saint PetersburgReferences
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