The role of genetic factors in the pathogenesis of primary open-angle glaucoma. Part 1. Connective tissue
- 作者: Zhuravleva A.N.1, Kirillova M.O.1, Zueva M.V.1, Kadyshev V.V.2
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隶属关系:
- Helmholtz National Medical Research Center of Eye Diseases
- Research Centre for Medical Genetics
- 期: 卷 14, 编号 1 (2021)
- 页面: 89-100
- 栏目: Reviews
- ##submission.dateSubmitted##: 03.12.2020
- ##submission.dateAccepted##: 03.04.2021
- ##submission.datePublished##: 09.06.2021
- URL: https://journals.eco-vector.com/ov/article/view/52972
- DOI: https://doi.org/10.17816/OV52972
- ID: 52972
如何引用文章
详细
The article presents an analytical review of works devoted to molecular and genetic studies in primary open-angle glaucoma from the perspective of the concept of hereditary inferiority of the connective tissue of the eye (“scleral component”), and the entire body as a whole, as triggers in the development of the disease. The relationship between the main theories of the pathogenesis of glaucoma optical neuropathy and the determining role of molecular and genetic mechanisms of specific changes in the eye tissue is shown. The clinical features of primary open-angle glaucoma in patients with a family history are analyzed. Potentially new directions for preclinical diagnosis of glaucoma and pathogenetically oriented therapy are proposed.
全文:
作者简介
Anastasiia Zhuravleva
Helmholtz National Medical Research Center of Eye Diseases
编辑信件的主要联系方式.
Email: zh.eye@mail.ru
ORCID iD: 0000-0001-8381-2124
SPIN 代码: 9358-5060
PhD, MD of Highest Qualification, Scientific Researcher
俄罗斯联邦, 14/19 Sadovaya-Chernogryazskaya str., Moscow, 105062Maria Kirillova
Helmholtz National Medical Research Center of Eye Diseases
Email: mkirillova.92@mail.ru
ORCID iD: 0000-0002-1813-4408
Postgraduate Student
俄罗斯联邦, 14/19 Sadovaya-Chernogryazskaya str., Moscow, 105062Marina Zueva
Helmholtz National Medical Research Center of Eye Diseases
Email: visionlab@yandex.ru
ORCID iD: 0000-0002-0161-5010
Dr. Sci. (Biol.), Professor
俄罗斯联邦, 14/19 Sadovaya-Chernogryazskaya str., Moscow, 105062Vitaliy Kadyshev
Research Centre for Medical Genetics
Email: vvh.kad@gmail.com
ORCID iD: 0000-0003-3665-982X
Cand. Sci. (Med.), Senior researcher, Associate Professor
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