Management of young girls with labial adhesion in the clinical and diagnostic Center of N.V. Dmitrieva Regional Children’s Clinical Hospital

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Aim. This study aimed to compare the effectiveness of conservative treatment methods, namely, estriol-containing cream and non-hormonal drug, in girls with labial adhesion (LA) in the clinical and diagnostic center of N.V. Dmitrieva Regional Children’s Clinical Hospital.

Materials and Methods. A retrospective analysis of pediatric clinical cases of labial adhesion (n=300) was carried out in N.V. Dmitrieva Regional Children’s Clinical Hospital in the period from 2016 to 2018. The study included 150 girls diagnosed with labial adhesion who were treated with estriol-containing cream (study group) and 150 girls with the same diagnosis (control group) who were treated with a non-hormonal gel containing onion extract 10 g, heparin 5000 IU, and allantoin. The age of the participants ranged from 4 months to 2 years and 2 months. Informed consent was obtained from the girls’ parents for the examination of the child, use of estriol-containing drug or a drug of non-hormonal composition, and processing of personal data. Recovery was considered the absence of recurrent synechiae for 2 years, improvement as not more than one recurrence not earlier than 6 months after the previous treatment, and no effect as two or more recurrences earlier than 6 months.

Results. In the main group, recovery, improvement, and no effect were achieved in 108 (72%), 39 (26%), and 3 (2%) girls, respectively. In the control group, recovery, improvement, and no effect was achieved in 30 (20%), 75 (50%), and 45 (30%) girls, respectively.

Conclusion. The results revealed the effectiveness and safety of using estriol-containing drugs in young girls diagnosed with labial adhesion.

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Tatiana V. Tazina

Ryazan State Medical University

Author for correspondence.
ORCID iD: 0000-0003-1029-0390
SPIN-code: 7059-9793
ResearcherId: D-7640-2018

MD, PhD, Associate Professor of the Department of Surgery

Russian Federation, Ryazan, Russia

Natalia B. Duzhnikova

N.V. Dmitrieva Regional Children's Clinical Hospital

ORCID iD: 0000-0001-7961-4547
SPIN-code: 7018-1274
ResearcherId: D-5927-2018


Russian Federation, Ryazan, Russia

Oksana S. Aleshkina

City Clinical Hospital № 8

SPIN-code: 1540-3607
ResearcherId: AAF-3924-2019

Deputy Chief Medical Officer

Russian Federation, Ryazan, Russia


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Supplementary files

Supplementary Files
1. Fig. 1. Number of labial adhesion cases in the Ryazan region, identified in 2014-2018 on visits to a doctor and on prophylactic examination 7

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Copyright (c) 2021 Tazina T.V., Duzhnikova N.B.

Свидетельство о регистрации СМИ ПИ № ФС77-76803 от 24 сентября 2019 года выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).

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