Immunomorphological CHARACTERISTICS experimental chronic autoimmune prostatitis

Abstract

In experiments on Wistar rats was reproduced by a model of chronic autoimmune prostatitis introduction homogenate additional sexual glands of rats. For morphometrical and morphological study of histological slides of the prostate were identified degenerative and proliferative epithelial changes acini, inflammatory infiltration, focal fibrosis. For immunofluoresence study revealed deposits of IgG in the basal plate epithelial acini processing sections of prostate serum of rats with chronic prostatitis. In the culture fluid of splenocytes was reduced levels of IL-4, TNF-α.

References

  1. Урология. Национальное руководство /Н.А. Лопаткин [и др.]; под ред. Н.А. Лопаткина.-М.ГЭОТАР-Медицина, 2009. -538с
  2. Mathis D., Benoist C., A decade of AIRE. Nat.Rev.Immunol. 2007 7: P.645-650
  3. Motrich R.D., Macconi M., Riera C.M., Rivero V.E., Autoimmune prostatitis: State of the Art. Scand J Immunol <javascript:AL_get(this,%20'jour',%20'Scand%20J%20Immunol.');>.2007 Aug-Sep;66 (2-3) P. 217-227
  4. Orsilles M.A., Depiante-Depaoli M. Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis. The Prostate 1998 (34) P.270-274 5.
  5. Pacheco-Rupil B, Depiante-Depaoli M, Casadio B. Experimental autoimmune damage to rat male accessory glands. II. T cell requirement in adoptive transfer of specific tissue damage. Am J Reprod Immunol. 1984 Jan-Feb;5(1):15-9. 6.
  6. Rizzi M <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rizzi%20M%22%5BAuthor%5D>., Ferrera F <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ferrera%20F%22%5BAuthor%5D>., Filaci G <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Filaci%20G%22%5BAuthor%5D>., Indiveri F <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Indiveri%20F%22%5BAuthor%5D>., Disruption of immunological tolerance: role of AIRE gene in autoimmunity. Autoimmun Rev. <javascript:AL_get(this,%20'jour',%20'Autoimmun%20Rev.');> 2006 Feb;5(2):P.145-147 7.
  7. Xiao-hui Zhou, Lian-da Li, Li-mao Wu, Increased inflammatory Factors Activity in model rat with experimental autoimmune prostatitis. Arch. of Androl 2007 P.49-52
  8. Hou Y., DeVoss J., Dao V., Kwek S., Simko J.P., Douglas G., Fong An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest. 2009 July 1; 119(7): P.2031-2041
  9. Zhang Q.Y <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Zhang%20QY%22%5BAuthor%5D>., Mo Z.N <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Mo%20ZN%22%5BAuthor%5D>., Liu X.D <http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liu%20XD%22%5BAuthor%5D>., Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis. Nat.J.of Androl. 2010 16(1):P.84-88

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2010 Tsvetkov I.S., Mkhitarov V.A., Tsvetkov I., Mkhitarov V.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Media Registry Entry of the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor) PI No. FS77-76803 dated September 24, 2019.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies