Levels of Corticosterone and Glucose in Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Duration

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INTRODUCTION: Mammals are almost constantly exposed to a variety of stressors. The changes in the concentration of corticosterone and the level of glucose in blood of animals under such conditions seems relevant for understanding the influence of repeated stress effects on endocrine and metabolic processes.

AIM: To study the concentrations of corticosterone and glucose in blood of rats in different time periods of prolonged low-intensity unpredictable stress.

MATERIALS AND METHODS: Experiments were carried out on 42 male Wistar rats. Individuals of the experimental groups were subjected to 7-day cycles of alternating stressors using a modified model of chronic unpredictable mild stress with presentation of different stressors. The concentration of corticosterone and glucose in blood was determined at 1, 2, 3 and 4 weeks of observation.

RESULTS: A pronounced decrease in corticosterone levels was found in rats at 1 week of stress exposure, followed by a slow recovery by the end of 4th week. Blood glucose level increased at 2 weeks of exposure.

CONCLUSION: The data obtained illustrate the specificity of changes in the levels of glucose and corticosterone in the blood of mammals in different time periods of chronic stress. These changes characterize the dysregulation of the integrative physiological systems in relatively early periods of chronic stress with the subsequent development of adaptation in the later stages of repeated stress exposures.

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作者简介

Dar’ya Skripkina

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

编辑信件的主要联系方式.
Email: skripkina_dv@academpharm.ru
ORCID iD: 0000-0002-1283-0955
SPIN 代码: 1448-7185
俄罗斯联邦, Moscow

Anastasiya Abramova

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Email: abramova_ayu@academpharm.ru
ORCID iD: 0000-0001-5940-3056
SPIN 代码: 1790-3941

д.м.н.

俄罗斯联邦, Moscow

Batozhab Shoibonov

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Email: shoybonov_bb@academpharm.ru
ORCID iD: 0000-0001-7061-6706
SPIN 代码: 5412-9790

Cand. Sci. (Chem.)

俄罗斯联邦, Moscow

Irina Alekseyeva

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Email: alekseeva_iv@academpharm.ru
ORCID iD: 0000-0001-9236-5143
SPIN 代码: 3539-5592

Cand. Sci. (Biol.)

俄罗斯联邦, Moscow

Ekaterina Nikenina

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Email: nikenina_ev@academpharm.ru
ORCID iD: 0000-0003-4869-0576
SPIN 代码: 8808-5006

Cand. Sci. (Biol.)

俄罗斯联邦, Moscow

Sergey Pertsov

Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Email: pertsov_ss@academpharm.ru
ORCID iD: 0000-0001-5530-4990
SPIN 代码: 3876-0513

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Moscow

参考

  1. Selye H. The stress of life. New–York: McGraw-Hill; 1956.
  2. Abramova AYu, Koplik EV, Alekseyeva IV, et al. Blood glucose level in rats with different behavioral activity in the dynamics of repeated stress exposures. I. P. Pavlov Russian Medical Biological Herald. 2019;27(1):10–9. (In Russ). doi: 10.23888/PAVLOVJ201927110-19
  3. Martyusheva AS, Subbotina AYu, Abramova AYu, et al. Changes in metabolic parameters of rats in different age periods after prenatal stress. I. P. Pavlov Russian Medical Biological Herald. 2022;30(4):471–80. (In Russ). doi: 10.17816/PAVLOVJ106532
  4. Kalinichenko LS, Koplik EV, Pertsov SS. Cytokine profile of peripheral blood in rats with various behavioral characteristics during acute emotional stress. Bull Exp Biol Med. 2014;156(4):441-444. doi: 10.1007/s10517-014-2369-4
  5. Pertsov SS. Role of the hypothalamic suprachiasmatic nucleus in the effect of melatonin on the thymus, adrenal glands, and spleen in rats. Bull Exp Biol Med. 2006;141(4):383–6. doi: 10.1007/s10517-006-0177-1
  6. Kryzhanovskiy GN, Akmayev IG, Magayeva SV, et al. Neyro-immunoendokrinnyye vzaimodeystviya v norme i patologii. Moscow: Meditsinskaya kniga; 2010. (In Russ).
  7. Kryzhanovskiy GN. Dizregulyatsionnaya patologiya. Moscow: Meditsina; 2002. (In Russ).
  8. Gulyaeva NV. The Neurochemistry of Stress: the Chemistry of the Stress Response and Stress Vulnerability. Neyrokhimiya. 2018;35(2):111–4. (In Russ). doi: 10.7868/S1027813318020012
  9. Mazurina NV, Leskova IV, Troshina EA, et al. Obesity and stress: endocrine and social aspects of the problem in the modern Russian society. Obesity and Metabolism. 2019;16(4):18–24. (In Russ). doi: 10.14341/omet9975
  10. Gutsol L, Guzovskaiia E, Serebrennikova S, et al. Stress (general adaptation syndrome) Lecture. Baikal Medical Journal. 2022;1(1):70–80. (In Russ). doi: 10.57256/2949-0715-2022-1-70-80
  11. Willner P, Towell A, Sampson D, et al. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 1987;93(3): 358–64. doi: 10.1007/bf00187257
  12. Кrupina NA, Khlebnikova NN, Orlova IN, et al. Effects of chronic mild stress in Wistar and August rats: behavior and monoamine content in the striatum. Pathogenesis. 2012;10(2):50–8. (In Russ).
  13. Smirnova AV, Lagutina LD, Trubitsyna IE, et al. Features of anesthesia in rats at abdominal operations. Experimental & Clinical Gastroenterology. 2012;(5):62–5. (In Russ).
  14. Tyurenkov IN, Filina IS, Gumilevskiy BY, et al. The influence of immunization on adaptation by chronic stress of animals. Fundamental Research. 2014;(7, Pt 2):368–71. (In Russ).
  15. Skripkina DV, Abramova AYu, Shoibonov BB, et al. Level of cytokines and C3 complement in the blood of rats under conditions of chronic unpredictable stress of different durations. Bull Exp Biol Med. 2024;177(3):280–4. (In Russ). doi: 10.47056/0365-9615-2024-177-3-280-284
  16. Wolowczuk I, Verwaerde C, Viltart O, et al. Feeding our immune system: impact on metabolism. Clin Dev Immunol. 2008;2008:639803. doi: 10.1155/2008/639803
  17. Starosel’nikov AN, Gusev KA, Mironova OB, et al. Modern Aspects of the Participation of Interleukin-1 Beta and Interleukin-6 in the Regeneration and Metabolic Processes of Bone Tissue (Literature Review). Nauka Molodykh (Eruditio Juvenium). 2023;11(3):447–58. (In Russ). doi: 10.23888/HMJ2023113447-458

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