Management of young girls with labial adhesion in the clinical and diagnostic Center of N.V. Dmitrieva Regional Children’s Clinical Hospital

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Aim. This study aimed to compare the effectiveness of conservative treatment methods, namely, estriol-containing cream and non-hormonal drug, in girls with labial adhesion (LA) in the clinical and diagnostic center of N.V. Dmitrieva Regional Children’s Clinical Hospital.

Materials and Methods. A retrospective analysis of pediatric clinical cases of labial adhesion (n=300) was carried out in N.V. Dmitrieva Regional Children’s Clinical Hospital in the period from 2016 to 2018. The study included 150 girls diagnosed with labial adhesion who were treated with estriol-containing cream (study group) and 150 girls with the same diagnosis (control group) who were treated with a non-hormonal gel containing onion extract 10 g, heparin 5000 IU, and allantoin. The age of the participants ranged from 4 months to 2 years and 2 months. Informed consent was obtained from the girls’ parents for the examination of the child, use of estriol-containing drug or a drug of non-hormonal composition, and processing of personal data. Recovery was considered the absence of recurrent synechiae for 2 years, improvement as not more than one recurrence not earlier than 6 months after the previous treatment, and no effect as two or more recurrences earlier than 6 months.

Results. In the main group, recovery, improvement, and no effect were achieved in 108 (72%), 39 (26%), and 3 (2%) girls, respectively. In the control group, recovery, improvement, and no effect was achieved in 30 (20%), 75 (50%), and 45 (30%) girls, respectively.

Conclusion. The results revealed the effectiveness and safety of using estriol-containing drugs in young girls diagnosed with labial adhesion.

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作者简介

Tatiana Tazina

Ryazan State Medical University

编辑信件的主要联系方式.
Email: tazina@inbox.ru
ORCID iD: 0000-0003-1029-0390
SPIN 代码: 7059-9793
Researcher ID: D-7640-2018

MD, PhD, Associate Professor of the Department of Surgery

俄罗斯联邦, Ryazan, Russia

Natalia Duzhnikova

N.V. Dmitrieva Regional Children's Clinical Hospital

Email: duzhnickova.nat@yandex.ru
ORCID iD: 0000-0001-7961-4547
SPIN 代码: 7018-1274
Researcher ID: D-5927-2018

obstetrician-gynecologist

俄罗斯联邦, Ryazan, Russia

Oksana Aleshkina

City Clinical Hospital № 8

Email: info@eco-vector.com
SPIN 代码: 1540-3607
Researcher ID: AAF-3924-2019

Deputy Chief Medical Officer

俄罗斯联邦, Ryazan, Russia

参考

  1. Batyrova ZK, Uvarova EV, Namazova-Baranova LS, et al. Clinico-anamnestic peculiarities in girls with recurrent labia minora adhesion: risk factors. Reproduktivnoye Zdorov’ye Detey i Podrostkov. 2014;(2):20-7. (In Russ).
  2. Batyrova ZK, Uvarova EV, Namazova-Baranova LS, et al. Adhesions of the labia minora in young girls: what a pediatric gynecologist should do. Current Pediatrics. 2012;11(2):118-21. (In Russ).
  3. Subbotina SV. Kliniko-immunologicheskiye osobennosti vul’vovaginitov u devochek [dissertation]. Chelyabinsk; 2000. Available at: https://viewer.rus neb.ru/ru/000200_000018_RU_NLR_bibl_1167245. Accessed: 2019 November 19.
  4. Uvarova EV, Sultanova FSh. Nespetsificheskiye vaginity u detey i podrostkov. Nedetskiye detskiye problemy. Consilium Provisorum. 2013;3(5):24-6. (In Russ).
  5. Pleshkova EM, Yaylenko AA, Khimova YuA. Gy-necological diseases in infant and preschool girls with infections of the urinary system. Voprosy Prakticheskoi Pediatrii. 2011;6(6):40-3. (In Russ).
  6. Abdulazizova FA, Mardonova SM. The etiology and pathogenesis of rotation of small human lips in girls of early childhood period. Avicenna. 2018; (22):16-22. (In Russ).
  7. Statisticheskiy sbornik. 2014. Available at: https:// minzdrav.gov.ru/ministry/61/22/stranitsa-979/statis ticheskie-i-informatsionnye-materialy/statistichesk iy-sbornik-2014-god. Ac-cessed: 2019 November 29.
  8. Zdravookhraneniye v Ryazanskoy oblasti: statis-ticheskiy sbornik. 2019. Available at: https://gks.ru/ bgd/regl/b19_34/Main.htm. Ac-cessed: 2019 November 29.
  9. Batyrova ZK, Uvarova EV, Kumykova ZKh, et al. Labial adhesions: international guidelines for practitioners. Pediatric and Adolescent Reproductive Health. 2018;14(4):32-5. (In Russ). doi:10.24411/ 1816-2134-2018-14003
  10. Rubinstein A, Rahman G, Risso P, et al. Labial adhesions: experience in a children’s hospital. Archivos Argentinos de Pediatria. 2018;116(1):65-8. doi: 10.5546/aap.2018.eng.65
  11. Bacon JL, Romano ME, Quint EH. Clinical Recommendation: Labial Adhesions. Journal of Pediatric and Adolescent Gynecology. 2015;28(5):405-9. doi: 10.1016/j.jpag.2015.04.010
  12. Velander MH, Mikkelsen DB, Bygum A. Labial agglutinations in prepubertal girls: effect of topical oestrogen. Acta Dermato-Venereologica. 2009;89(2): 198-9. doi: 10.2340/00015555-0586
  13. Çağlar M.K. Serum estradiol levels in infants with and without labial adhesions: the role of estrogen in the etiology and treatment. Pediatric Dermatology. 2007; 24(4):373-5. doi: 10.1111/j.1525-1470.2007.00493.x
  14. Smetnik VP. Estrogeny. Moscow: Prakticheskaya meditsina; 2012. P. 128-33.
  15. Omar HA. Management of labial adhesions in prepubertal girls. Journal of Pediatric and Adolescent Gynecology. 2000;13(4):183-5. doi:10.1016/s 1083-3188(00)00064-4
  16. Kumetz LM, Quint EH, Fisseha S, et al. Estrogen treatment success in recurrent and persistent labial agglutination. Journal of Pediatric and Adolescent Gynecology. 2006;19(6):381-4. doi: 10.1016/j.jpag. 2006.09.008
  17. Yang TM, To WWK. Paediatric Labial Adhesions: Evaluation of Response to Topical Oestrogen
  18. Therapy. Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2007;7(1):37-40.
  19. Myers JB, Sorensen CM, Wisner BP, et al. Betamethasone cream for the treatment of prepubertal labial adhesions. Journal of Pediatric and Adoles-cent Gynecology. 2006;19(6):407-11. doi: 10.1016/j.jpag. 2006.09.005
  20. Uvarova YeV, Batyrova ZK, Kumykova ZKh, et al. Microbiota and Local Immunity of Vaginal Mucosa in Very Young Girls: Normal and Abnormal Parameters. Doctor.Ru. 2017; (3):59-65. (In Russ).
  21. Watanabe T, Matsubara S, Fujinaga Y, et al. Manual separation followed by local cleanliness for pediatric labial adhesion. Journal of Obstetrics and Gynaecology Research. 2010;36(3):667-70. doi:10.1111/ j.1447-0756.2010.01192.x

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