Features of sexual development, immune status and biochemical parameters in boys suffering from acne

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Abstract

Among skin diseases in children and adolescents, the most common pathology is acne. The main pathogenetic link of acne in adolescents is hormonal imbalance. The effect on the sebaceous glands of high concentrations of dihydrotestosterone causes a change not only in the quantitative but also in the qualitative composition of the sebaceous secretion. The study is devoted to assessing the characteristics of sexual development, immune status and biochemical parameters in boys suffering from acne. Materials and methods.

Materials and methods. A comparative analysis of the state of immunity, sexual development, biochemical parameters of 147 boys suffering from acne, and 142 healthy boys who do not suffer from acne.

It was found that the immune status of boys suffering from acne was characterized by a decrease in cytotoxic lymphocytes. In the peripheral blood of these boys, serum interferon γ, tumor necrosis factor α, interleukins 1, 2, 8 and 10, as well as small circulating immune complexes were significantly higher than in the boys of the control group. In boys suffering from acne, in the puberty period, the concentration of prolactin in 13–14 years is significantly lower, and testosterone levels are significantly higher than in boys of the control group of the same age. At 15–17 years of age, the concentration of luteinizing hormone in boys with acne is significantly lower, and testosterone is higher than in boys in the control group. Evaluation of the degree of formation of secondary sexual characteristics indicates that boys suffering from acne differed from their peers from the control group by a small advance in sexual development. Thus, boys suffering from acne, characterized by advanced and disharmonious puberty.

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About the authors

Elena N. Pilnik

Northern State Medical University

Author for correspondence.
Email: pilnik.76@mail.ru

Postgraduate Student, Central Research Laboratory

Russian Federation, Arkhangelsk

Denis V. Zaslavsky

St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation

Email: venerology@gmail.com

MD, PhD, Dr. Sci. (Med.), Professor, Department of dermatovenereology

Russian Federation, Saint Petersburg

Alexander O. Pyatibrat

St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation

Email: a5brat@yandex.ru

MD, PhD, Dr. Sci. (Med.), Associate Professor, Department of Mobilization Healthcare Training & Catastrophe Medicine

Russian Federation, Saint Petersburg

References

  1. Альбанова В.И. Новое в диете и медикаментозном лечении акне // Дерматология в России. – 2018. – S1. – С. 13–21. [Al’banova VI. Novoe v diete i medikamentoznom lechenii akne. Dermatologija v Rossii. 2018;(S1):13-21. (In Russ.)]
  2. Баранов А.А., Кучма В.Р., Сухарева Л.М., и др. Универсальная оценка физического развития младших школьников. – М.: НЦЗД РАМН; 2010. – 34 c. [Baranov AA, Kuchma VR, Suhareva LM., et al. Universal’naja ocenka fizicheskogo razvitija mladshih shkol’nikov. Moscow: NCZD RAMN; 2010. 34 p. (In Russ.)]
  3. Баринова А.Н. Этиология, патогенез, классификация и клиническая картина вульгарных угрей. Современный взгляд на проблему // Российский семейный врач. –2018. – Т. 22. – № 3. – С. 14–22. [Barinova AN. Etiology, pathogenesis, classification and clinical picture of acne vulgaris. Modern view of the problem. Russian Family Doctor. 2018;22(3):14-22. (In Russ.)] https://doi.org/10.17816/RFD2018314-22.
  4. Баринова А.Н. Современные методы лечения и реабилитации больных с вульгарными угрями // Российский семейный врач. – 2018. – Т. 22. – № 4. – С. 5–18. [Barinova AN. Modern methods of treatment and rehabilitation of patients with acne vulgaris. Rrussian Family Doctor. 2018;22(4):5-18. (In Russ.)] https://doi.org/10.17816/RFD201845-18.
  5. Велиева Н.М., Велиева Р.М. Влияние вульгарных угрей на качество жизни и психическое здоровье молодых людей // Научный медицинский вестник Югры. – 2015. – № 1–2 (7–8). – C. 76–79. [Velieva NM, Velieva RM. Vlijanie vul’garnyh ugrej na kachestvo zhizni i psihicheskoe zdorov’e molodyh ljudej. Nauchnyj medicinskij vestnik Jugry. 2015;(1-2):76-79.
  6. Гланц С. Медико-биологическая статистика / под ред. Н.Е. Бузикашвили, Д.В. Самойлова — М.: Практика, 1998. – 459 с. [Glantz S. Medical and biological statistics. Buzikashvili NE, Samojlova DV, eds. Moscow: Praktika; 1998. 459 p. (In Russ.)]
  7. Клиническая лабораторная диагностика: национальное руководство. В 2 томах. Том I / под ред. В.В. Долгова, В.В. Меньшикова. – М.: ГЭОТАР-Медиа, 2012. – 928 с. [Klinicheskaja laboratornaja diagnostika: nacional’noe rukovodstvo. Dolgov VV, Men’shikov VV, eds. – Moscow: GJeOTAR-Media; 2012. 928 p. (In Russ.)]
  8. Жильцова Е.Е., Ермошина Н.П. Психосоматические аспекты качества жизни у больных акне // Архивъ внутренней медицины. – 2016. – № S1. – С. 79. [Zhiltsova EE, Ermoshina NP. Psychosomatic aspects of the quality of life in patients with acne. Arhiv vnutrennej mediciny. 2016;(S1):79. (In Russ.)]
  9. Мурашкин Н.Н., Иванов А.М., Заславский Д.В., Камилова Т.А. Вопросы эффективности и безопасности применения системных ретиноидов в терапии акне у подростков // Вестник дерматологии и венерологии. – 2010. – Т. 86 — № 5. – С. 112–116. [Murashkin NN, Ivanov AM, Zaslavsky DV, Kamilova T.A. Issues of the effectiveness and safety of the use of systemic retinoids in the treatment of acne in adolescents. Vestnik dermatologii i venerologii. 2010;86(5):112-116. (In Russ.)] https://doi.org/10.25208/vdv983.
  10. Носачева О.А., Каркашадзе Г.А., Намазова-Баранова Л.С. Психоэмоциональное состояние детей и подростков с угревой болезнью // Педиатрическая фармакология. –2012. – Т. 9. – № 4. – С. 42–47. [Nosacheva OA, Karkashadze GA, Namazova-Baranova LS. Psychoemotional state of children and adolescents with acne. Pediatric Pharmacology. 2012;9(4): 42-47. (In Russ.)] https://doi.org/10.15690/pf.v9i4. 389.
  11. Попова О.В., Кузнецов С.И. Нейрогуморальные механизмы патогенеза угревой болезни и их психосоматическая коррекция в практике врача-терапевта // Курский научно-практический вестник «Человек и его здоровье». – 2011. – № 3. – С. 122–125. [Popova OV, Kuznetsov SI. Neurohumoral mechanisms of acne pathogenesis and their psychosomatic correction in the practice of a general practitioner. Kurskij nauchno-prakticheskij vestnik “Chelovek i ego zdorov’e”. 2011;(3)122-125. (In Russ.)]
  12. Рябова В.В., Кошкин С.В., Зайцева Г.А., Евсеева А.Л. Характер изменений иммунологических показателей у пациентов с тяжелыми формами акне // Вятский медицинский вестник. – 2017. – № 4. – C. 23–27. [Ryabova VV, Koshkin SV, Zaitseva GA, Evseeva AL. The nature of changes in immunological parameters in patients with severe acne. Vjatskij medicinskij vestnik. 2017;(4):23-27. (In Russ.)]
  13. Самцов А.В. Акне и акнеформные дерматозы. – М.: Ютком, 2009. – 287 c. [Samcov AV. Akne i akneformnye dermatozy. Moscow: Jutkom; 2009. 287 p. (In Russ.)]
  14. Цой Н.О., Цой О.Г. Иммунорегуляторная функция патогенетически значимых при угревой болезни гормонов // Клиническая Медицина Казахстана. – 2014. – № 2. – С. 26–32. [Tsoi NO, Tsoi OG. Immunoregulatory function of hormones pathogenetically significant in acne. Klinicheskaja Medicina Kazahstana. 2014;(2):26-32. (In Russ.)]
  15. Cameron N. The methods of auxological anthropometry. In: Human Growth. Falkner F, Tanner JM, eds. New York: Plenum; 1986. P. 35-90.
  16. Lucky AW, Biro FM, Huster GA. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol. 1994;130(3):308-314. https://doi.org/10.1001/archderm.130.3.308.
  17. Tanner JM. Normal growth and techniques ofgrowth assessment: Review. Clin. J. Endocrinol. Metab. 1986;15(3):411-451. https://doi.org/10.1016/s0300-595x(86)80005-6.
  18. Uhlenhake E, Yentzer BA, Feldman SR. Acne vulgaris and depression: a retrospective examination. J Cosmet Dermatol. 2010;9(1):59-63. https://doi.org/10.1111/j.1473-2165.2010.00478.x.
  19. Wolkenstein P, Machovcová A, Szepietowski JC, et al. Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents / young adults in 7 European countries. J Eur Acad Dermatol Venereol. 2018;32(2):298-306. https://doi.org/10.1111/jdv.14475.

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