Use of autologous mesenchymal stem cells derived from adipose tissue for the treatment of hyaline cartilage defects in laboratory animals: a literature review

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Abstract

BACKGROUND: Degenerative/dystrophic cartilage diseases are an epidemiologically important challenge in modern traumatology and orthopedics. The use of autologous mesenchymal stem cells to repair cartilage defects is currently the most promising treatment option.

AIM: The aim of this paper was to review the literature on the use of adipose tissue-derived mesenchymal stem cells to repair articular cartilage defects in laboratory animals.

MATERIALS AND METHODS: Recent and historical Russian and English literature was searched in Google Scholar, Cyberleninka, PubMed, eLibrary, Mendeley, Science Direct databases for over 20 years. A total of 113 papers were selected, and 25 papers that met the inclusion criteria were selected based on full-text materials and abstracts.

RESULTS: Literature shows that autologous adipose-derived mesenchymal stem cells stimulate hyaline cartilage regeneration. The vast majority of studies show that the addition of both differentiated and undifferentiated cells accelerates cartilage repair, regardless of the composition of the vehicle matrix or gel. Adipose-derived mesenchymal stem cells can also be used as a stand-alone technology without any vehicles.

CONCLUSIONS: There is still no ideal graft to restore cartilage tissue, despite a wide range of technologies, surgical techniques and materials for repairing cartilage defects. However, mesenchymal stem cells improve the rate of defect repair and may become a new therapeutic strategy for degenerative/dystrophic cartilage diseases.

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About the authors

Polina A. Pershina

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Author for correspondence.
Email: polinaiva2772@gmail.com
ORCID iD: 0000-0001-5665-3009
SPIN-code: 2484-9463

MD, PhD Student

Russian Federation, Saint Petersburg

Yuri A. Novosad

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; Peter the Great Saint Petersburg Polytechnic University

Email: novosad.yur@yandex.ru
ORCID iD: 0000-0002-6150-374X
SPIN-code: 3001-1467

MD, PhD Student

Russian Federation, Saint Petersburg; Saint Petersburg

Kristina N. Rodionova

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; Peter the Great Saint Petersburg Polytechnic University

Email: rkn0306@mail.ru
ORCID iD: 0000-0001-6187-2097
SPIN-code: 4627-3979
Russian Federation, Saint Petersburg; Saint Petersburg

Marat S. Asadulaev

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: marat.asadulaev@yandex.ru
ORCID iD: 0000-0002-1768-2402
SPIN-code: 3336-8996

MD, PhD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg

Vyacheslav I. Zorin

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: traumaturner@yandex.ru
ORCID iD: 0000-0002-9712-5509
SPIN-code: 4651-8232

MD, PhD, Cand. Sci. (Medicine), Associate Professor

Russian Federation, Saint Petersburg

Pavel I. Bortulev

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: pavel.bortulev@yandex.ru
ORCID iD: 0000-0003-4931-2817
SPIN-code: 9903-6861

MD, PhD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg

Sergey V. Vissarionov

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: vissarionovs@gmail.com
ORCID iD: 0000-0003-4235-5048
SPIN-code: 7125-4930

MD, PhD, Dr. Sci. (Medicine), Professor, Corresponding Member of the RAS

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Study design scheme. MSCs, mesenchymal stem cells; SVF, stromal vascular fraction

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