在儿童股骨髁II-III期剥脱性骨软骨炎的综合治疗中使用富含血小板的自体血浆的前景。初步报告

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论证。股骨髁剥脱性骨软骨炎是一种以软骨下骨病变为特征的疾病，随后形成骨坏死。即使对包括儿童在内的此类患者进行了及时治疗，仍有近一半的病例会在远期出现骨关节病。新技术和改良技术的开发将有助于提高对这种病症患者的治疗效果。

本研究的目的是通过3次注射富含血小板血浆，配合血运重建受累区隧道化，评价临床小型系列儿童解剖型骨软骨炎患者的治疗效果。

材料和方法。7名II-III期剥脱性骨软骨炎患者接受了通过三次注射富含血小板血浆（1次术中骨内注射，2次随后的关节内注射）对骨坏死灶进行血管再造刺激的治疗方法。随访时间为10[6-11]个月，最长时间为12个月。

结果。研究发现，血小板丰富血浆疗法（PRP-therapy）能有效增强机械方法刺激骨软骨生成的效果。

结论。矫形生物学技术的应用是一个积极发展且前景广阔的领域，包括对患有股骨髁骨软骨炎的儿童进行综合的治疗。然后，需要对所研究的这组患者进行进一步随访，以评估其长期疗效。

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作者简介

Anastasiia I. Arakelyan

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: a_bryanskaya@mail.ru
ORCID iD: 0000-0002-3998-4954
SPIN 代码: 9224-5488
Scopus 作者 ID: 57193271649

MD, PhD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Vyacheslav I. Zorin

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: zoringlu@yandex.ru
ORCID iD: 0000-0002-9712-5509
SPIN 代码: 4651-8232

MD, PhD, Cand. Sci. (Med.), Assistant Professor

俄罗斯联邦, Saint Petersburg

Ekaterina A. Zakharyan

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: zax-2008@mail.ru
ORCID iD: 0000-0001-6544-1657
SPIN 代码: 4851-9908
Scopus 作者 ID: 58033194200

MD, PhD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Maxim S. Nikitin

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: doknikitin@yandex.ru
ORCID iD: 0000-0001-8987-3489
SPIN 代码: 9480-1637
Scopus 作者 ID: 57193277911

MD, orthopedic and trauma surgeon

俄罗斯联邦, Saint Petersburg

Сергей Yu. Semenov

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

编辑信件的主要联系方式.
Email: sergey2810@yandex.ru
ORCID iD: 0000-0002-7743-2050
SPIN 代码: 8093-3924
Scopus 作者 ID: 57216524677

MD, orthopedic and trauma surgeon

俄罗斯联邦, Saint Petersburg

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补充文件

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2. Fig. 1. Patient L., 13 years old. Arthroscopy image. Osteochondritis dissecans of the medial condyle of the femur, stage II, and destruction focus measured 2.0 × 2.0 cm

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3. Fig. 2. Centrifuged autologous blood of the patient, divided into fractions (a); using the “internal” syringe, 4.0 mL of a suspension of platelet-rich plasma was taken (b)

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4. Fig. 3. Patient L., 13 years old. Tunneling of the destruction focus of the medial condyle of the femur with a Kirschner wire

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5. Fig. 4. Changes in pain syndrome reduction according to the visual analog scale (VAS)

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6. Fig. 5. Patient K., 12 years old, computed tomography of the left knee joint, frontal sections: a, osteochondritis dissecans of the medial condyle of the femur, stage II; b, control computed tomogram after 6 months; restoration of the necrotic zone

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7. Fig. 6. Patient K., 12 years old, magnetic resonance imaging of the left knee joint, frontal sections: a, osteochondritis dissecans of the medial condyle of the femur, stage II; b, control magnetic resonance imaging after 6 months; restoration of the necrotic zone

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