Risk factors for the development of congenital giant nevi in children
- 作者: Filippova O.V.1, Provorova E.N.1, Proshchenko Y.N.1,2
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隶属关系:
- MEDSI, Сenter for The Treatment of Giant Nevi
- H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery
- 期: 卷 12, 编号 2 (2024)
- 页面: 197-204
- 栏目: Clinical studies
- ##submission.dateSubmitted##: 05.05.2024
- ##submission.dateAccepted##: 11.06.2024
- ##submission.datePublished##: 25.06.2024
- URL: https://journals.eco-vector.com/turner/article/view/631696
- DOI: https://doi.org/10.17816/PTORS631696
- ID: 631696
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BACKGROUND: Congenital giant melanocytic nevi (CMN) occur approximately in 1 of 250,000–500,000 newborns. According to foreign literature, the risk of malignancy of a melanocytic nevus varies widely within 5%–42%.
AIM: This study aimed to identify possible risk factors for CMN in children and determine the most common location and actual list of examination.
MATERIALS AND METHODS: The study enrolled 104 mother–child pairs, where the children had CMN. The control group included 60 mother–child pairs, in which the children had no CMN.
RESULTS: CMN were located on the head in 42.4% of cases, which was the most frequent localization. The most frequent localizations also included the trunk and simultaneous location of nevi on several body segments. Abnormalities in thyroid hormone levels were noted in 12.5% of the mothers. The frequency of large nevi in the grandparents of children with CMN (13.5%) was significantly higher than that in their parents (mother, 1.9%; father, 2.9%). In addition, 19.2% of the children were examined by an oncologist or are on a dispensary register with an oncologist. Moreover, 4.8% of the patients were observed by a neurologist. Magnetic resonance imaging was performed once in 19.2% of the children, who underwent genetic testing. No foci of melaniform cell accumulation in the nervous tissue were detected in any examined child.
CONCLUSIONS: The most common location of CMN is the head and torso – areas of risk of damage to the central nervous system by melanoform cells. The survey results of parents of the main group identified the following as risk factors for CMN development in children: a history of miscarriage or frozen pregnancy, thyroid hormone abnormalities, CMN in grandparents, ARVI during pregnancy, particularly in the first trimester, and visiting a solarium and using long-lasting gel polishes during pregnancy.
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作者简介
Olga Filippova
MEDSI, Сenter for The Treatment of Giant Nevi
Email: olgafil-@mail.ru
ORCID iD: 0000-0002-1002-0959
SPIN 代码: 8055-4840
MD, PhD, Dr. Sci. (Med.)
俄罗斯联邦, Saint PetersburgEkaterina Provorova
MEDSI, Сenter for The Treatment of Giant Nevi
Email: ekaterina.pro.surgeon@yandex.ru
ORCID iD: 0000-0002-8528-1926
MD
俄罗斯联邦, Saint PetersburgYaroslav Proshchenko
MEDSI, Сenter for The Treatment of Giant Nevi; H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery
编辑信件的主要联系方式.
Email: yar2011@list.ru
ORCID iD: 0000-0002-3328-2070
SPIN 代码: 6953-3210
MD, PhD, Dr. Sci. (Med.)
俄罗斯联邦, Saint Petersburg; Saint Petersburg参考
- Moustafa D, Blundell AR, Hawryluk EB. Congenital melanocytic nevi. Curr Opin Pediatr. 2020;32(4):491–497. doi: 10.1097/MOP.0000000000000924
- Casttilla EE, da GracaDurta M, Orioli-Parreiras JM. Epidemiology of congenital pigmentednaevi: incidence rates and relative frequencies. Br J Dermotol. 1981;104:307–315. doi: 10.1111/j.1365-2133.1981.tb00954.x
- Doroshenko MB, Utyashev IA, Demidov LV, et al. Clinical and biological features of giant congenital nevi in children. Pediatrics. Journal named after G.N. Speransky. 2016;95(4):50–56. EDN: WFBHEF
- Merchan-Cadavid S, Ferro-Morales A, Solano-Gutierrez E, et al. Giant congenital melanocytic nevus in a pediatric patient: case report. Plast Reconstr Surg Glob Open. 2021;9(11). doi: 10.1097/GOX.0000000000003940
- Quaba AA, Wallace AF. The incindence of malignant melanoma (0 to 15 years of age) arising in “large” congenital nevocellularnervi. Plast Reconstr Surg. 1986;78(2):174–181. doi: 10.1097/00006534-198608000-00004
- Watt AJ, Kotsis SV, Chung KC. Risk of melanoma arising in large congenital melanocytic nevi: a systematic review. Plast Reconstr Surg. 2004;113(7):1968–1974. doi: 10.1097/01.prs.0000122209.10277.2a
- Stark MS. Large-giant congenital melanocytic nevi: moving beyond NRAS mutations. J Invest Dermatol. 2019;139(4):756–759. doi: 10.1016/j.jid.2018.10.003
- Recio A, Sánchez-Moya AI, Félix V, et al. Congenital melanocytic nevus syndrome: a case series. Actas Dermosifiliogr. 2017;108(9):e57–e62. doi: 10.1016/j.ad.2016.07.025
- Dorofeeva MYu, editor. Tuberous sclerosis. Diagnosis and treatment. Moscow: ADARE; 2017.
- Rayala BZ, Morrell DS. Common skin conditions in children: congenital melanocytic nevi and infantile hemangiomas. FP Essent. 2017;453:33–37.
- Viana AC, Gontijo B, Bittencourt FV. Giant congenital melanocytic nevus. An Bras Dermatol. 2013;88(6):863–878. doi: 10.1590/abd1806-4841.20132233
- De Bella K., Szudek J., Friedman J.M. Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics. 2000;105(3):608–614. doi: 10.1542/peds.105.3.608
- Drouin V, Marret S, Petitcolas J, et al. Prenatal ultrasound abnormalities in a patient with generalized neurofibromatosis type 1. Neuropediatrics. 1997;28(2):120–121. doi: 10.1055/s-2007-973684
- Prygunova TM, Karpovich EI, Chernigina MN, et al. Course peculiarities of neurocutaneous melanosis in children. Current Pediatrics. 2016;15(5):513–521. EDN: WZKNDL doi: 10.15690/vsp.v15i5.1626
- Foster RD, Williams ML, Barkovich AJ, et al. Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children. J Plast Reconstr Surg. 2001;107(4):933–941. doi: 10.1097/00006534-200104010-00005
- Curless RG. Use of “unidentified bright objects” on MRI for diagnosis of neurofibromatosis 1 in children. Neurology. 2000;55(7):1067–1068. doi: 10.1212/wnl.55.7.1067-a
- Bekiesińska-Figatowska M, Sawicka E, Żak K, et al. Age related changes in brain MR appearance in the course of neurocutaneous melanosis. Eur J Radiol. 2016;85(8):1427–1431. doi: 10.1016/j.ejrad.2016.05.014
- Lalor L, Busam K, Shah K. Prepubertal melanoma arising within a medium-sized congenital melanocytic nevus. Pediatr Dermatol. 2016;33(6):e372–e374. doi: 10.1111/pde.12961
- Fledderus AC, Widdershoven AL, Lapid O, et al. Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis. Orphanet J Rare Dis. 2022;17(1):95. doi: 10.1186/s13023-022-02234-8