自体脂肪来源间充质干细胞在实验动物透明软骨缺损治疗中的应用（文献综述）

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背景。软骨组织的退行性疾病是现代创伤学和骨科领域中具有重要流行病学意义的问题。软骨缺损修复的困难在于软骨组织的低再生能力，而使用自体间充质干细胞修复软骨缺损被认为是当前研究中最具前景的方向之一。

研究目的。综述文献中关于脂肪来源间充质干细胞在实验动物软骨缺损修复中的应用研究。

材料与方法。本文基于过去20年的俄文和英文文献，使用关键词在 Google Scholar、Ciberleninka、 PubMed、eLibrary、Mendeley 和 Science Direct 等数据库中进行检索。共筛选出113篇文献，并从中挑选出25篇符合纳入标准的全文和摘要研究进行分析。

结果。文献数据显示，自体脂肪来源间充质干细胞在透明软骨缺损修复中能够促进再生。在绝大多数研究中，无论基质载体或凝胶的组成如何，添加分化或未分化细胞均可显著加速软骨组织修复过程。此外，脂肪来源间充质干细胞还可作为一种独立技术，无需载体直接应用于治疗。

结论。尽管已有多种技术、手术方法和材料用于修复软骨缺损，目前尚未找到能够完全再生软骨组织的理想移植物。然而，脂肪来源间充质干细胞在实验研究中表现出显著的再生潜力，能够加速软骨缺损修复，并可能成为治疗软骨退行性疾病的新策略。进一步研究应集中于临床转化应用， 以验证其在人体软骨修复中的安全性和有效性。

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作者简介

Polina A. Pershina

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

编辑信件的主要联系方式.
Email: polinaiva2772@gmail.com
ORCID iD: 0000-0001-5665-3009
SPIN 代码: 2484-9463

MD, PhD Student

俄罗斯联邦, Saint Petersburg

Yuri A. Novosad

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; Peter the Great Saint Petersburg Polytechnic University

Email: novosad.yur@yandex.ru
ORCID iD: 0000-0002-6150-374X
SPIN 代码: 3001-1467

MD, PhD Student

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Kristina N. Rodionova

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; Peter the Great Saint Petersburg Polytechnic University

Email: rkn0306@mail.ru
ORCID iD: 0000-0001-6187-2097
SPIN 代码: 4627-3979
俄罗斯联邦, Saint Petersburg; Saint Petersburg

Marat S. Asadulaev

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: marat.asadulaev@yandex.ru
ORCID iD: 0000-0002-1768-2402
SPIN 代码: 3336-8996

MD, PhD, Cand. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Vyacheslav I. Zorin

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: traumaturner@yandex.ru
ORCID iD: 0000-0002-9712-5509
SPIN 代码: 4651-8232

MD, PhD, Cand. Sci. (Medicine), Associate Professor

俄罗斯联邦, Saint Petersburg

Pavel I. Bortulev

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: pavel.bortulev@yandex.ru
ORCID iD: 0000-0003-4931-2817
SPIN 代码: 9903-6861

MD, PhD, Cand. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Sergey V. Vissarionov

H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery

Email: vissarionovs@gmail.com
ORCID iD: 0000-0003-4235-5048
SPIN 代码: 7125-4930

MD, PhD, Dr. Sci. (Medicine), Professor, Corresponding Member of the RAS

俄罗斯联邦, Saint Petersburg

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2. Fig. 1. Study design scheme. MSCs, mesenchymal stem cells; SVF, stromal vascular fraction

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