Benign prostatic hyperplasia with high PSA values: a clinical case

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Abstract

The article presents a clinical case of treatment of a patient with benign prostatic hyperplasia and high serum prostate-specific antigen values. Prostate-specific antigen (total) blood level – 160.1 ng/ml. The volume of the prostate gland is 230 cm3, the average proportion is 53 mm. The patient underwent a full range of diagnostic tests. A retropubic transvesical adenomectomy was performed. During a histological examination of the preparation, no data was obtained for the presence of an oncological process.

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About the authors

Vladimir V. Protoshchak

S.M. Kirov Military Medical Academy

Email: protoshakurology@mail.ru
ORCID iD: 0000-0002-4996-2927
SPIN-code: 6289-4250

Dr. Sci. (Med.), Professor, Head of Department of Urology and Clinic of Urology

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044

Mihail V. Paronnikov

S.M. Kirov Military Medical Academy

Email: paronnikov@mail.ru
SPIN-code: 6147-7357

Head of Department, Clinic of Urology

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044

Evgenij G. Karpushchenko

S.M. Kirov Military Medical Academy

Email: z_karpushe@mail.ru
ORCID iD: 0000-0001-7464-5926
SPIN-code: 3753-4990

Cand. Sci. (Med.), Senior Lecturer, Department of Urology

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044

Valentina V. Ignateva

S.M. Kirov Military Medical Academy

Email: ignateva_vv@mail.ru
ORCID iD: 0000-0002-5719-5852

Clinical resident, Department of Urology

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044, Russia;

Dmitrii V. Ovchinnikov

S.M. Kirov Military Medical Academy

Email: dv.ovchinnikov-vma@yandex.ru
ORCID iD: 0000-0001-8408-5301
SPIN-code: 5437-3457
Scopus Author ID: 36185599800

Cand. Sci. (Med.), Associate Professor

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044

Alina A. Erohina

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: lokitrikster@yandex.ru
SPIN-code: 1768-8760

Pathologist

Russian Federation, 6, Akademika Lebedeva St., Saint Petersburg, 194044

References

  1. Rak predstatel’noj zhelezy. Klinicheskie rekomendacii. 2021. 96 p. (In Russ.) Available from: https://cr.minzdrav.gov.ru/recomend/12_3
  2. Bertok T, Bertokova A, Hroncekova S, et al. Novel prostate cancer biomarkers: etiology, clinical performance and sensing applications. Chemosensors. 2021;9(8):205. doi: 10.3390/chemosensors9080205
  3. Protoshchak VV, Andreev EA, Karpushhenko EG, et al. Prostate cancer and dogs’ sense of smell: opportunities of noninvasive diagnostics. Urologia. 2019;5:22–26. (In Russ.) doi: 10.18565/urology.2019.5.22-26
  4. Solovieva S, Karnaukh M, Panchuk V, et al. Potentiometric multisensor system as a possible simple tool for non-invasive prostate cancer diagnostics through urine analysis. Sensors and Actuators B: Chemical. 2019;289:42–47. doi: 10.1016/j.snb.2019.03.072
  5. Deev V, Solovieva S, Andreev E, et al. Prostate cancer screening using chemometric processing of GC–MS profiles obtained in the headspace above urine samples. Journal of Chromatography B. 2020;1155:122298. DOI: 1016/j.jchromb.2020.122298

Supplementary files

Supplementary Files
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1. Fig. 1. Magnetic resonance imaging of the pelvis with contrast enhancement: a – sagittal section; b – frontal section

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2. Fig. 2. Histological preparation of prostate adenoma: 1 – glandular component; 2 – stromal component. Hematoxylin-eosin staining, magnification ×20

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3. Fig. 3. Histological specimen of the prostatic part of the urethra: 1 – urothelium with neutrophilic infiltration (chronic inflammation); 2 – stromal component with lymphoplasmacytic infiltration (chronic inflammation). Hematoxylin-eosin staining, magnification ×20

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