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Fig. 1. A hypothetical model of interactions between urothelial cells (urothelium), afferent and efferent nerve endings (neurothelium), vessels (endothelium), smooth muscle cells and myofibroblasts of the lower urinary tract [10, 11]. NO – nitrogen oxide; AдР – adrenergic receptor; ATФ – adenosine triphosphate; AЦХ – acetylcholine; Бр – bradykinin receptor; ГКД – detrusor smooth muscle cell; МР – muscarinic receptor; НикР – nicotinic receptor; HP – neurokinin receptor; НЭ – norepinephrine; П2Р – purinergic receptor subtype 2; П2X and П2Y – purinergic receptors of the X and Y subtypes; ПГ – prostaglandins; СП – substance R; ТирКР – tyrosine kinase receptor with high affinity for nerve growth factor; TРПК – transit receptor of potential channels; ФРН – nerve growth factor |