Sperm DNA fragmentation: etiology, pathogenesis, the influence on reproductive function

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Abstract

The literature review of sperm DNA fragmentation is evaluated. Russian and foreign literary data over the past 10 years, including fundamental researching of the evaluation of the gametes genome integrity, are analyzed. The main etiological factors and the possible reasons of the DNA breaks formation on the different stages of spermatogenesis are described. The influence of the sperm oxidative stress reaction to the DNA integrity is analyzed. The relationship between DNA fragmentation of spermatozoa pregnancy and live birth rates in the assisted reproductive techniqueare noted. Risk of the recurrent pregnancy losses in male infertility cases with the sperm DNA damage is presented. Review confirms the significant prognostic value of sperm DNA fragmentation detection in infertility cases. Further studies in evaluation of pathogenesis of sperm DNA have a clinical interest to reproductive health physicians.

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About the authors

Maxim N. Korshunov

Central State Medical Academy of President’s Affairs Administration of the Russian Federation

Author for correspondence.
Email: m_korshunov@bk.ru
ORCID iD: 0000-0001-9355-2872

Cand. Sci. (Med.), Associate Professor

Russian Federation, Marshala Timoshenko str.,19, Moscow, Russia, 121359

Ekaterina S. Korshunova

Central State Medical Academy of President’s Affairs Administration of the Russian Federation

Email: e_korshunova@mail.ru
ORCID iD: 0000-0003-1492-934X

Cand. Sci. (Med.), Associate Professor

Russian Federation, Marshala Timoshenko str.,19, Moscow, Russia, 121359

Sergey P. Darenkov

Central State Medical Academy of President’s Affairs Administration of the Russian Federation

Email: darenkov@list.ru
ORCID iD: 0000-0002-3797-7160

Dr. Sci. (Med.), Professor, Head of the Department of Urology

Russian Federation, Marshala Timoshenko str.,19, Moscow, Russia, 121359

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