Dynamics of endothelian function in different treatment strategies in stable ischemic heart disease

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Abstract


Aim. To assess the dynamics of endothelial function by determining circulating endothelial cells in peripheral blood in patients with stable ischemic heart disease within various treatment approaches.

Material and methods. The study involved 98 patients with stable ischemic heart disease and 30 patients in the control group without coronary atherosclerosis. Endothelial function was assessed by determining the number of circulating endothelial cells in peripheral blood using flow cytofluorimetry with antibodies to cell surface markers: CD146+CD45 at the baseline. Depending on the treatment tactics, the study participants were divided into 3 groups: the medicamental therapy group, the group of coronary stenting, and the group of coronary bypass surgery. After 3 months from the baseline, dinamics assessment of endothelial dysfunction was performed.

Results. Endothelial dysfunction was observed in all patients with obstructive lesions of the coronary blood flow and associated with effort angina class and anatomical severity of coronary disease. Improvement of endothelial function was facilitated by lipid-lowering therapy. Revascularization by coronary stenting impaired endothelial function in three months after the intervention. Mycoardial revascularization by coronary bypass did not impair endothelial function.

Conclusion. Examination of endothelial dysfunction by determining the number of circulating endothelial cells in peripheral blood can be used to assess the severity of endothelial dysfunction in patients with IHD receiving lipid-lowering therapy and undergoing surgical revascularization.


Sergey A. Sayganov

North-Western State Medical University named after I.I. Mechnikov

Email: sergey.sayganov@szgmu.ru
Scopus Author ID: 56512453000

Russian Federation, 191015, Saint-Petersburg, Kirochnaya street, 41

doctor of medical science, head of department of cardiology

Anastasiia M. Kuzmina-Krutetskaia

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: akrutetskaya@gmail.com
ORCID iD: 0000-0002-9905-4804

Russian Federation, 191015, Saint-Petersburg, Kirochnaya street, 41

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Supplementary files

Supplementary Files Action
1. Fig. 1. Number of circulating endothelial cells (CEC) in different groups View (90KB) Indexing metadata

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