Secondary risk factors of sudden cardiac death and genes of arterial hypertension

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Abstract


Purpose. To study the influence of polymorphisms of arterial hypertension genes and their various combinations on individual risk factors of sudden cardiac death.

Materials and methods. 319 young people from 18 to 24 years of age who are entering military service by conscription were examined. The survey identified 69 individuals with signs of increased risk of sudden cardiac death after being examined for secondary risk factors of sudden cardiac death and taken a blood test to determine the polymorphisms of the genes AGT 521 C>T, GNB3 825 C>T, CYP11B2 344 C>T, NOS3 786 T>C.

Results. The greatest influence on the severity of secondary risk factors was exerted by the following variants of a combination of gene polymorphisms: AGT 521 C>T and NOS3 786 T>C in the individuals with a heterozygous risk variant, both genes showed a significant increase in the duration of the corrected QT interval, heart rate, and a decrease in heart rate variability. AGT 521 C>T and CYP11B2 344 C>T — homozygous risk variant of the CYP11B2 344 C>T and the heterozygous risk variant AGT 521 C>T is associated with a longer duration of the corrected QT interval, and the heterozygous risk variant for both genes is associated with higher heart rate values. AGT 521 C>T and GNB3 825 C>T — combination of a homozygous risk variant of the gene GNB3 825 C>T and the heterozygous variant of the gene AGT 521 C>T is associated with the greatest effect on a heart rate.

Conclusions. The presence of a homozygous risk variant of the gene NOS3 786 T>C, a heterozygous risk variant of the gene GNB3 825 C>T is prognostically unfavorable for its effect on the severity of secondary risk factors for sudden cardiac death. The combination of the heterozygous variant AGT 521 C>T with a heterozygous variant of NOS3 786 T>C and a homozygous risk variant by the gene CYP11B2 344 C>T and the heterozygous risk variant AGT 521 C>T are also the most unfavorable in terms of its effect on secondary risk factors for sudden cardiac death. Secondary risk factors of sudden cardiac death are influenced by both individual polymorphisms of genes of arterial hypertension, and their various combinations.


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About the authors

Vasilii A. Kachnov

Military Medical Academy n.a. S.M. Kirov Ministry of Defence of Russian Federation

Author for correspondence.
Email: kvasa@mail.ru
ORCID iD: 0000-0002-6601-5366
SPIN-code: 2084-0290

Russian Federation, Saint-Petersburg

Ph. D. (Medicine), doctoral student 

Vadim V. Tyrenko

Military Medical Academy n.a. S.M. Kirov Ministry of Defence of Russian Federation

Email: vadim_tyrenko@mail.ru
SPIN-code: 3022-5038

Russian Federation, Saint-Petersburg

doctor of medicine, professor, head of the Department of intermediant therapy clinic

Svetlana N. Kolyubaeva

Military Medical Academy n.a. S.M. Kirov Ministry of Defence of Russian Federation

Email: ksnwma@mail.ru

Russian Federation, Saint-Petersburg

doctor of biology senior researcher at the research laboratory of cell technologies of the research department of medical and biological research of the research center

Lilia A. Myakoshina

Military Medical Academy n.a. S.M. Kirov Ministry of Defence of Russian Federation

Email: lmyakoshina@yandex.ru

Russian Federation, Saint-Petersburg

doctor of clinical and laboratory diagnostics of the Department of intermediant therapy clinic

Alexandra S. Buntovskaya

Military Medical Academy n.a. S.M. Kirov Ministry of Defence of Russian Federation

Email: sandrarebel@mail.ru

Russian Federation, Saint-Petersburg

doctor of clinical and laboratory diagnostics of the research laboratory of cell technologies

References

  1. Шляхто Е.В., Арутюнов Г.П., Беленков Ю.Н., и др. Национальные рекомендации по определению риска и профилактике внезапной сердечной смерти. – 2-е изд. – М.: Медпрактика-М, 2018. – 247 с. [Shlyakhto EV, Arutyunov GP, Belenkov YuN, et al. Natsional’nye rekomendatsii po opredeleniyu riska i profilaktike vnezapnoy serdechnoy smerti 2nd ed. Moscow: Medpraktika-M; 2018. 247 p. (In Russ.)]
  2. Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC) endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36(41):2793-867. https://doi.org/10.1093/eurheartj/ehv316.
  3. Deo R, Norby FL, Katz R, et al. Development and validation of a sudden cardiac death prediction model for the general population. Circulation. 2016;134(11):806-816. https://doi.org/10.1161/CIRCULATIONAHA.116.023042.
  4. Wellens HJ, Schwartz PJ, Lindemans FW, et al. Risk stratification for sudden cardiac death: Current status and challenges for the future. Eur Heart J. 2014;35(25):1642-1651. https://doi.org/10.1093/eurheartj/ehu176.
  5. Tereshchenko L, Soliman EZ, Davis BR, et al. Risk stratification of sudden cardiac death in hypertension. J Electrocardiol. 2017;50(6):798-801. https://doi.org/10.1016/ j.jelectrocard.2017.08.012.
  6. Shenasa M, Shenasa H. Hypertension, left ventricular hypertrophy and sudden cardiac death. Int J Cardiol. 2017;237:60-63. https://doi.org/10.1016/j.ijcard.2017. 03.002.
  7. Verdecchia P, Angeli F, Cavallini C, et al. Sudden cardiac death in hypertensive patients. Hypertension. 2019;73(5): 1071-1078. https://doi.org/10.1161/HYPERTENSIONAHA. 119.12684.
  8. Jayaraman R, Reinier K, Nair S, et al. Risk factors of sudden cardiac death in the young: Multiple-year community-wide assessment. Circulation. 2018;137(15):1561-1570. https://doi.org/10.1161/CIRCULATIONAHA.117.031262.
  9. Sessa F, Anna V, Messina G, et al. Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018;10(2):166-177. https://doi.org/ 10.18632/aging.101386.
  10. Kannel WB, Schatzkin A. Sudden death: Lessons from subsets in population studies. J Am Coll Cardiol. 1985;5(6 Suppl):141В-149В. https://doi.org/10.1016/s0735-1097(85)80545-3.
  11. Shaper AG, Wannamethee G, Macfarlane PW, et al. Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. Br Heart J. 1993;70(1):49-55. https://doi.org/10.1136/hrt.70.1.49.
  12. Самарина О.В., Ковтун О.П. Генетические аспекты артериальной гипертензии у детей // Медицинская наука и образование Урала. – 2016. – Т. 17. – № 4. – С. 49–53. [Samarina OV, Kovtun OP. Genetic aspects of arterial hypertension in children. Meditsinskaya nauka i obrazovanie Urala. 2016;17(4):49-53. (In Russ.)]
  13. Милославский Д.К., Коваль С.Н., Снегурская И.А., и др. Альдостеронсинтаза, полиморфизм ее гена CYP11B2 при артериальной гипертензии и ассоциированных с нею кардиоваскулярных заболеваниях (обзор литературы) // Артериальная гипертензия. – 2017. – № 4. – С. 18–28. [Miloslavsky DK, Koval SN, Snegurskaya IA. Aldosterone synthase, polymorphism of its CYP11B2 gene in arterial hypertension and cardiovascular diseases associated with it (literature review). Arterial’naya gipertenziya. 2017;(4):18-28. (In Russ.)]. https://doi.org/10.22141/2224-1485.4.54.2017.109541.
  14. Mahmood M, Mian ZS, Afzal A, Frossard PM. G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. Med Sci Monit. 2005;11(1):CR6-9.
  15. Clark CJ, Davies E, Anderson NH, et al. Alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. Hypertension. 2000;36:990-994. https://doi.org/10.1161/01.hyp.36.6.990.
  16. Бойцов С.А., Линчак Р.М., Недбайкин А.М., и др. Эпидемиология внезапной сердечной смерти: что мы знаем сегодня? // Клиническая практика. – 2014. – № 4. – С. 13–19. [Boitsov SA, Linchak RM, Nedbaikin AM, et al. Epidemiologiya vnezapnoy serdechnoy smerti: chto my znaem segodnya? Journal of clinical practice. 2014;(4):13-19. (In Russ.)]
  17. Osman J, Tan SC, Lee PY, et al. Sudden Cardiac Death (SCD) — risk stratification and prediction with molecular biomarkers. J Biomed Sci. 2019;26(1):39. https://doi.org/10.1186/s12929-019-0535-8.

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Copyright (c) 2020 Kachnov V.A., Tyrenko V.V., Kolyubaeva S.N., Myakoshina L.A., Buntovskaya A.S.

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