Shared pathological mechanisms of systemic lupus erythematosus and affective disorders

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The high prevalence and variability of neurological and psychiatric symptoms in systemic lupus erythematosus has become the basis for emphasizing the special neuropsychiatric form of the disorder. Affective disorders (pathological changes in mood and anxiety) are the second most common neuropsychiatric manifestations in patients with systemic lupus erythematosus. However, the current nomenclature primarily focuses on the general clinical manifestations of affective disorders in neuropsychiatric form systemic lupus erythematosus, without evaluating the problems of their etiopathogenesis. Thereby, the aim of this review is the integration of information on the pathological mechanisms of depression and anxiety in patients with systemic lupus erythematosus. The available data on the biological aspects of the anxiety and depression in systemic lupus erythematosus indicate that the complex pathological models may be the best approach for studying, diagnosing, and treating comorbid pathology. The latter can be based on expanding the existing clinical categories, supplementing them with data on pathological mechanisms specific to particular sub-cohorts of patients. Such an approach can provide the specific and most effective preventive, diagnostic and therapeutic measures for each category of patients.

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Grigory V. Rukavishnikov

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Author for correspondence.
ORCID iD: 0000-0002-5282-2036

MD, Cand. Sci. (Med.)

Russian Federation, 3 Bekhtereva str., Saint Petersburg, 192019

Anna A. Smirnova

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID iD: 0000-0002-4703-0712
Russian Federation, 3 Bekhtereva str., Saint Petersburg, 192019

Nikolay G. Neznanov

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; I.P. Pavlov First Saint Petersburg State Medical University

ORCID iD: 0000-0001-5618-4206

MD, Dr. Sci. (Med.), Professor

Russian Federation, 3 Bekhtereva str., Saint Petersburg, 192019; Saint Petersburg

Vadim I. Mazurov

North-Western State Medical University named after I.I. Mechnikov

ORCID iD: 0000-0002-0797-2051
SPIN-code: 6823-5482
Scopus Author ID: 16936315400
ResearcherId: A-8944-2016

MD, Dr. Sci. (Med.), Professor, Honoured Science Worker, Academician of the RAS

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

Galina E. Mazo

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID iD: 0000-0001-7036-5927

MD, Dr. Sci. (Med.)

Russian Federation, 3 Bekhtereva str., Saint Petersburg, 192019


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Copyright (c) 2021 Rukavishnikov G.V., Smirnova A.A., Neznanov N.G., Mazurov V.I., Mazo G.E.

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