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Primary hyperaldosteronism is considered to be the most common cause of secondary hypertension. Therefore a relevance of early diagnosis of primary aldosteronism is obvious. The article discusses the possibility of using the determination of precursors of aldosterone in blood and urine samples by high effective liquid chromatography as an additional diagnostic criterion. The method is safe for the patients who have contraindications to recommended confirmatory tests. It can be used in patients with uncontrolled hypertension and high risk of cardiovascular complications. Our data showed that increased levels of blood corticosterone, 18-hydroxycorticosterone in blood and urine samples are laboratory signs of primary aldosteronism. We consider measurement of 18-hydroxycorticosterone blood level for early differential diagnosis of various types of primary aldosteronism.

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About the authors

D V Rebrova

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation

N V Vorokhobina

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation

L I Velikanova

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation


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