THE VALUE OF HIGH EFFECTIVE LIQUID CHROMATOGRAPHYIN THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISM



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Abstract

Primary hyperaldosteronism is considered to be the most common cause of secondary hypertension. Therefore a relevance of early diagnosis of primary aldosteronism is obvious. The article discusses the possibility of using the determination of precursors of aldosterone in blood and urine samples by high effective liquid chromatography as an additional diagnostic criterion. The method is safe for the patients who have contraindications to recommended confirmatory tests. It can be used in patients with uncontrolled hypertension and high risk of cardiovascular complications. Our data showed that increased levels of blood corticosterone, 18-hydroxycorticosterone in blood and urine samples are laboratory signs of primary aldosteronism. We consider measurement of 18-hydroxycorticosterone blood level for early differential diagnosis of various types of primary aldosteronism.

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About the authors

D V Rebrova

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation

N V Vorokhobina

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation

L I Velikanova

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation

References

  1. Панькин, В.И. Гиперальдостеронизм: определение, этиология, классификация, клинические признаки и синдромы, диагностика, лечение [Электронный ресурс] / В.И. Панькин // Международный эндокринологический журнал. - 2011. - Т. 39. - № 7. URL: http://www.mif-ua.com/archive/article/23012 (дата обращения: 02.06.2013).
  2. Протащик, Д.В. Клинические особенности первичного гиперальдостеронизма / Протащик Д.В., Ворохобина Н.В., Шафигуллина З.Р., Лисицын А.А. // Вестник Северо-Западного государственного медицинского университета им. И.И.Мечникова. - 2013. - Т.5. - №4. - С. 114-119.
  3. Calhoun, D.A. Aldosteronism and hypertension / D.A. Calhoun // Clin. J. Am. Soc. Nephrol. - 2006. - Vol. 1. - P. 1039-1045.
  4. Culi, A. High prevalence of autonomous aldosterone secretion among patients with essential hypertension / A. Gouli., G. Kaltsas, A. Tzonou, A. Markou, I.I. Androulakis, D. Ragkou, K. Vamvakidis, G. Zografos, G. Kontogeorgos, G.P. Chrousos, G. Piaditis // Eur. J. Clin. Invest. - 2011. - Vol. 44. - P. 1227-1236.
  5. Hannemann, A. Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies / A. Hannemann,M. Bidlingmaier, N. Friedrich, J. Manolopoulou, A. Spyroglou, H. Volzke, F. Beuschlein, J. Seissler, R. Rettig, S.B. Felix, R. Biffar, A. Doring, C. Meisinger, A. Peters, H.E. Wichmann, M. Nauck, H. Wallaschofski, M. Reincke // Eur. J. Endocrinol. - 2012. - Vol. 167. - P. 7-15.
  6. Rossi, G.P. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients / G.P. Rossi, G. Bernini, C. Caliumi, G. Desideri, B. Fabris, C. Ferri, C. Ganzaroli, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, M. Mannelli, M.J. Mattarello, A. Moretti, G. Palumbo, G. Parenti, E. Porteri, A. Semplicini, D. Rizzoni, E. Rossi, M. Boscaro, A.C. Pessina, F. Mantero, PAPY Study Investigators// J. Amm. Coll. Cardiol. - 2006. - Vol. 48. - P. 2293-2300.
  7. Funder, J.W. Primary aldosteronism and low-renin hypertension: a continuum? / J.W. Funder // Nephrol. Dial. Transplant. - 2013. - Vol. 48. - P. 1625-1627.
  8. Rossi, G.P. Primary aldosteronism: an update on screening, diagnosis and treatment / G.P. Rossi, A.C. Pessina, A.M. Heagerty // J. Hypertens. - 2008. - Vol. 26. - P. 613-621.
  9. Young, W.F. Primary aldosteronism: renaissance of a syndrome / W.F. Young // Clin. Endocrinol. - 2007. - Vol. 66. - P. 607-618.
  10. Pappa, T. Pattern of adrenal hormonal secretion in patients with adrenal adenomas: the relevance of aldosterone in arterial hypertension / T. Pappa, L. Papanastasiou, G. Kaltsas, A. Markou, P. Tsounas, I. Androulakis, V. Tsiavos, G. Zografos, K. Vamvakidis, C. Samara, G. Piaditis// J. Clin. Endocrinol. Metab. - 2012. - Vol. 97. - N. 4. - P. 537-545.
  11. Заболевания надпочечников / под ред. проф. Н.В. Ворохобиной и проф. П.А. Сильницкого. - СПб.: Изд-во Политехн. ун-та, 2009. - 330 с.
  12. Funder, J.W. Case detection, diagnosis and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline / J.W. Funder, R.M. Carey, C. Fardella, C.E. Gomez-Sanches, F. Mantero, M. Stowasser, W.F. Young Jr., V.M. Montori// J. Clin. Endocrinol. Metab. - 2008. - Vol. 93. - P. 3266-3281.
  13. Satoh, F. Primary aldosteronism: a Japanese perspective / F. Satoh, R. Morimoto, Y. Iwakura, Y. Ono, M. Kudo, K. Takase, S. Ito// Rev. Endocrin. Metab. Disord. - 2011. -Vol. 12. - P. 11-14.
  14. Великанова, Л.И. Диагностическое значение высокоэффективной жидкостной хроматографии кортикостероидов. Учебное пособие / Л.И. Великанова. - СПб.: Изд-во ГБОУ ВПО СЗГМА им. И.И.Мечникова Минздрава России, 2013. - 27 с.
  15. Crane, M.G. Desoxycorticosterone secretion rates in hyperadrenocorticism / M.G. Crane, J.J. Harris // J. Clin. Endocr. - 1966. -Vol.26. - P. 1135-1143.
  16. Biglieri, E.G. The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism / E.G. Biglieri, M. Schambelan // J. Clin. Endocrinol. Metab. - 1979. - Vol. 49. - N. 1. - P. 87-91.
  17. Kem, D.C. The prediction of anatomical morphology of primary aldosteronism using serum 18-hydroxycorticosterone levels / D.C. Kem, K. Tang, C.S. Hanson, R.D. Brown, R. Painton, M.H. Weinberger, J.W. Hollifield// J. Clin. Endocrinol. Metab. - 1985. - Vol. 60. - N. 1. - P. 67-73.

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Copyright (c) 2014 Rebrova D.V., Vorokhobina N.V., Velikanova L.I.

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