Email this article MELATONIN EXCHANGE AT MULTIMORBID CARDIOVASCULAR PATHOLOGYWITH ANXIETY AND DEPRESSIVE DISORDERS IN YOUNG AND MIDDLE-AGED MEN
- Authors: Aflitonov MA1, Partsernyak SA1,2, Mironenko AN1,2, Partsernyak AS3, Topanova AA1
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Affiliations:
- North-West State Medical University named after I.I. Mechnikov
- City hospital №15, Saint-Petersburg
- Military Medical Academy named after S.M. Kirov
- Issue: Vol 7, No 3 (2015)
- Pages: 60-65
- Section: Reviews
- URL: https://journals.eco-vector.com/vszgmu/article/view/8507
- DOI: https://doi.org/10.17816/mechnikov20157360-65
- ID: 8507
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Abstract
Evaluate melatonin (MT) patterns excretion at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAD), hypertension, metabolic syndrome (MS)) with non-psychot- ic mental disorders (NPMD) anxiety/ depressive type. Identify the effectiveness of visual-auditory ef- fects in the treatment of these pathologies. Design and methods: The study included 70 men (mean age 37,46±6,74) with MCVP divided into 4 groups by simple random sampling, and 20 healthy men (mean age 38,3±6,73 g). Patients in Group 1 (n = 22) received standard therapy CAD, hypertension and NPMD, in group 2 (n = 25) standard therapy CAD, hypertension, NPMD and visual-auditory correction. Patients of group 3 (n = 23) received standard therapy CAD, hypertension, NPMD, visual-auditory correction and psychotherapy. Used in the study: complex psychological test methods and laboratory-instrumental evaluation of the cardiovascular system. Definition of 6-sulfatoxymelatonin (6-SMT) performed by ELI- SA using kits BÜHLMANNEK-M6S. Results: Identified change normal «dipper» pattern to «non- dip- per» and «night-peaker» (daily index blood pressure and 0-10% <0% (p <0,001) in all treatment groups. Patients 3 group observed achievement reference values of the night excretion after treatment 458±64-» 798±32 (before and after treatment, respectively) (p <0,001). In all groups after treatment was observed significantly change the type of NDP «severe depression», «clinical anxiety» to «mild depression»; «sub- clinical anxiety» (p <0,001). Conclusions: Patients with MCVP have abnormalities of MT content char- acterized by a decrease in nocturnal excretion of 6-SMT. Night pattern of 6-SMT excretion significantly correlated with severity of anxiety/ depression before and after treatment. Results of patients treated with visual auditory correction significantly better than patients of other groups (obtained reference intervals MT excretion, biochemical indices and normalization of psychological tests).
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About the authors
M A Aflitonov
North-West State Medical University named after I.I. Mechnikov
S A Partsernyak
North-West State Medical University named after I.I. Mechnikov; City hospital №15, Saint-Petersburg
A N Mironenko
North-West State Medical University named after I.I. Mechnikov; City hospital №15, Saint-Petersburg
A S Partsernyak
Military Medical Academy named after S.M. Kirov
A A Topanova
North-West State Medical University named after I.I. Mechnikov
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).