Comparative analysis of the effectiveness of neoadjuvant systemic therapy and primary surgical treatment of patients with BRCA - associated triple-negative T1 breast cancer

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BACKGROUND: BRCA-associated triple-negative breast cancer does not only have a better overall survival rate, but also a longer recurrence-free period in compatison to patients with sporadic breast cancer. BRCA-associated triple-negative breast cancer shows high sensitivity to chemotherapeutic agents, but the benefit of systemic neoadjuvant therapy for patients with tumor size ≤T1 in triple-negative breast cancer is unclear.

AIM: The aim of the study is to determine the recurrence rate in the patients with BRCA-associated triple-negative breast cancer and to determine the recurrence rate for the group of patients with tumor size ≤T1, depending on the initial treatment.

MATERIALS AND METHODS: The study includes the data of 129 patients diagnosed with BRCA-associated triple-negative breast cancer treated in the period from 2010 to 2022 at the Department of Breast Tumors of the N.N. Petrov National Medical Research Center of Oncology. All the patients have been divided into two groups depending on the initial treatment. Group I included 93 (72.1%) patients whose treatment was started with systemic neoadjuvant therapy, group II, whose initial treatment involved surgery, included 36 (27.9%) patients.

RESULTS: In group I, the number of recurrences was 22 (23.6%), and in group II — 6 (16.6%). Depending on the pathomorphological response to systemic neoadjuvant therapy, the patients of group I have been separated: in the group of patients with a complete pathomorphological response, the number of relapses was 6 (13.3%), and in the group of patients with a partial pathomorphological response — 16 (33.3%). A comparative analysis of 2 groups with tumor size ≤T1 has shown that in group I the number of patients with tumor size ≤T1 was 11 (11.8%) cases, and in group II — 16 (44.4%). Subgroup comparative analysis in group I, taking into account tumor size ≤T1, has shown that recurrence has not been observed when a complete pathomorphological response was achieved in 8 (17.7%) patients, and in the group with partial pathomorphological response in 3 (6.25%) patients with tumor size ≤T1. A relapse has been observed in 1 (2%) case. With clinical tumor size ≤T1 (n = 16), there was no recurrence in group II.

CONCLUSIONS: Patients diagnosed with BRCA-associated triple-negative breast cancer remain at a high risk of recurrence at a later stage of the disease, but this does not apply to patients with a tumor size ≤T1 since the difference in relapse-free survival [AP1] between patients, whose treatment was started with neoadjuvant systemic therapy and patients, whose initial treatment involved surgery % with a clinical tumor size ≤T1, is not confirmed.

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作者简介

Diana Enaldieva

N.N. Petrov National Medical Research Centre of Oncology

编辑信件的主要联系方式.
Email: dianaenaldieva932@gmail.com
ORCID iD: 0000-0002-2773-3111
SPIN 代码: 2372-3622

PhD student

俄罗斯联邦, Saint Petersburg

Roman Donskikh

N.N. Petrov National Medical Research Centre of Oncology

Email: Rdonskih@rambler.ru
ORCID iD: 0000-0002-9391-5327
SPIN 代码: 5111-8211

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Petr Krivorotko

N.N. Petrov National Medical Research Centre of Oncology

Email: dr.krivorotko@mail.ru
ORCID iD: 0000-0002-4898-9159
SPIN 代码: 2448-7506
Scopus 作者 ID: 36600762900

MD, Dr. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Evgeny Imyanitov

N.N. Petrov National Medical Research Centre of Oncology; Saint Petersburg State Pediatric State Medical University

Email: evgeny@imyanitov.spb.ru
ORCID iD: 0000-0003-4529-7891
SPIN 代码: 1909-7323

MD, Dr. Sci. (Med.), Professor, Correspondence Member of the RAS

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Elena Zhiltsova

N.N. Petrov National Medical Research Centre of Oncology

Email: ziltsova@yandex.ru
ORCID iD: 0000-0002-2029-4582
SPIN 代码: 3045-1704

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Anna Sokolenko

N.N. Petrov National Medical Research Centre of Oncology; Saint Petersburg State Pediatric State Medical University

Email: annasokolenko@mail.ru
ORCID iD: 0000-0001-6304-1609
SPIN 代码: 1256-9758
Scopus 作者 ID: 7004209770

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Tengiz Tabagua

N.N. Petrov National Medical Research Centre of Oncology

Email: tedo8308@mail.ru
ORCID iD: 0000-0003-1471-9473
SPIN 代码: 4466-6316

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Nikolay Amirov

N.N. Petrov National Medical Research Centre of Oncology

Email: amirovn17@gmail.com
ORCID iD: 0000-0002-2421-3284
SPIN 代码: 7793-4290

PhD student

俄罗斯联邦, Saint Petersburg

Roman Pesotsky

N.N. Petrov National Medical Research Centre of Oncology

Email: shipmeback@gmail.com
ORCID iD: 0000-0002-2573-2211
俄罗斯联邦, Saint Petersburg

Laysan Shaikhelislamova

N.N. Petrov National Medical Research Centre of Oncology

Email: leisyanka97@mail.ru
ORCID iD: 0000-0001-9623-3877
俄罗斯联邦, Saint Petersburg

Alexander Emelyanov

N.N. Petrov National Medical Research Centre of Oncology

Email: ae28111992@yandex.ru
ORCID iD: 0000-0002-0528-9937
SPIN 代码: 6312-4894
俄罗斯联邦, Saint Petersburg

Viktoria Mortada

N.N. Petrov National Medical Research Centre of Oncology

Email: vika-gukova@mail.ru
ORCID iD: 0000-0002-1982-5710
SPIN 代码: 3871-8774

PhD student

俄罗斯联邦, Saint Petersburg

Larisa Gigolaeva

N.N. Petrov National Medical Research Centre of Oncology

Email: gigosha532@gmail.com
ORCID iD: 0000-0001-7654-4336
SPIN 代码: 3521-7448

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Sergey Yerechshenko

N.N. Petrov National Medical Research Centre of Oncology

Email: dr.ereschenko@gmail.com
ORCID iD: 0000-0002-5090-7001
SPIN 代码: 5957-9137

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Alexander Komyakhov

N.N. Petrov National Medical Research Centre of Oncology

Email: komyahov@yandex.ru
ORCID iD: 0000-0002-6598-1669
SPIN 代码: 8286-4406

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Kirill Nikolaev

N.N. Petrov National Medical Research Centre of Oncology

Email: kirill.nikolaev87@gmail.com
ORCID iD: 0000-0003-3377-6369
SPIN 代码: 5627-6696

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Konstantin Zernov

N.N. Petrov National Medical Research Centre of Oncology

Email: konstantin_zernov@hotmail.com
ORCID iD: 0000-0002-2138-3982
SPIN 代码: 9186-5705

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Yana Bondarchuk

N.N. Petrov National Medical Research Centre of Oncology

Email: yana_bondarchuk_2015@mail.ru
ORCID iD: 0000-0002-6442-0106
SPIN 代码: 9546-3222

PhD student

俄罗斯联邦, Saint Petersburg

Ruslan Paltuev

N.N. Petrov National Medical Research Centre of Oncology

Email: paltuev@mail.ru
ORCID iD: 0000-0002-0871-9453
SPIN 代码: 9963-3032
Scopus 作者 ID: 6505715557

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Alexander Bessonov

Leningrad Regional Clinical Oncology Center

Email: dr.bessonov@gmail.com
ORCID iD: 0000-0002-6649-7641
SPIN 代码: 3553-4670

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Anna Artemyeva

N.N. Petrov National Medical Research Centre of Oncology

Email: oinochoya@gmail.com
ORCID iD: 0000-0002-2948-397X
SPIN 代码: 5760-5463

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Vladislav Semiglazov

N.N. Petrov National Medical Research Centre of Oncology; Pavlov First Saint Petersburg State Medical University

Email: oncology.spbgmu@mail.ru
ORCID iD: 0000-0002-8825-5221
SPIN 代码: 6786-9577
Scopus 作者 ID: 7006310596

д-р мед. наук

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Tatiana Semiglazova

N.N. Petrov National Medical Research Centre of Oncology

Email: tsemiglazova@mail.ru
ORCID iD: 0000-0002-4305-6691
SPIN 代码: 9773-3759
Scopus 作者 ID: 8562948700

MD, Dr. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Vladimir Semiglazov

N.N. Petrov National Medical Research Centre of Oncology

Email: ssemiglazov@mail.ru
ORCID iD: 0000-0003-0077-9619
SPIN 代码: 3874-9539
Scopus 作者 ID: 18838622600

MD, Dr. Sci. (Med.), Professor, Correspondence Member of the RAS

俄罗斯联邦, Saint Petersburg

Alexsey Belyaev

N.N. Petrov National Medical Research Centre of Oncology; North-Western State Medical University named after I.I. Mechnikov

Email: bam281060@yandex.ru
ORCID iD: 0000-0001-5580-4821
SPIN 代码: 9445-9473

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Saint Petersburg; Saint Petersburg

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