Assessment of the physical development of children with and without high thrombogenic risk factors in the Health Center for Children
- 作者: Elizarieva L.A.1, Galaktionova M.Y.2, Strozenko L.A.1, Lobanov Y.F.1, Boldenkova I.Y.1
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隶属关系:
- Altai State Medical University
- Юрий Федорович Лобанов
- 期: 卷 15, 编号 3 (2023)
- 页面: 63-73
- 栏目: Original research
- ##submission.dateSubmitted##: 03.06.2023
- ##submission.dateAccepted##: 30.10.2023
- ##submission.datePublished##: 14.12.2023
- URL: https://journals.eco-vector.com/vszgmu/article/view/472110
- DOI: https://doi.org/10.17816/mechnikov472110
- ID: 472110
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详细
BACKGROUND: Up to 65% diseases associated with pathological thrombus have been described; more than 100 thrombogenic risk factors leading to vascular accidents have been studied. It is known that physical development is an important indicator of health in children. The relationship between the presence of thrombogenic risk factors in various disorders of physical development in children has been studied.
AIM: To determine the relationship between physical development disorders in children and the presence of thrombogenic risk factors.
MATERIALS AND METHODS: The study included 396 children aged 14–18 years, who underwent physical growth assessment using the sigma deviation method and genetic testing to determine polymorphisms of folate cycle genes and polymorphisms of thrombophilia genes. Statistical processing was carried out using the application package Statistica 10.0 (StatSoft, Inc., USA).
RESULTS: The analysis of anthropometric indicators in children showed that in the group of the patients with thrombogenic risk factors, height and body weight values with average physical disharmonious development due to excess weight were statistically significantly higher than age-reference indicators.
CONCLUSIONS: Based on the results of the study, it has been shown that disharmony in physical development in children with high thrombogenic risk factors may be one of the risk factors for the development of thrombotic conditions.
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作者简介
Lilia Elizarieva
Altai State Medical University
Email: dr.liliaye@mail.ru
ORCID iD: 0000-0001-9350-2402
SPIN 代码: 2473-4690
Department Assistant
俄罗斯联邦, BarnaulMarina Galaktionova
Юрий Федорович Лобанов
Email: myugal@mail.ru
ORCID iD: 0000-0001-7437-0512
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, PskovLyudmila Strozenko
Altai State Medical University
编辑信件的主要联系方式.
Email: agmu_ordinatura@mail.ru
ORCID iD: 0000-0002-8586-1330
SPIN 代码: 4116-1023
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, BarnaulYuri Lobanov
Altai State Medical University
Email: ped2@agmu.ru
ORCID iD: 0000-0001-6284-1604
SPIN 代码: 6515-3794
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, BarnaulIrina Boldenkova
Altai State Medical University
Email: k-propdetbol@asmu.ru
ORCID iD: 0000-0001-9775-2636
SPIN 代码: 1005-5989
Cand. Sci. (Pharm.), Assistant Professor
俄罗斯联邦, Barnaul参考
- Elizar’eva LA, Strozenko LA, Lobanov YuF, Galaktionova MYu. Analysis of the quality of life of children examined at the Health Center. Russian Pediatric Journal. 2021;24(4):256–257. (In Russ.)
- Strozenko LA, Snigir’ OA, Lobanov YuF, et al. Genetic predictors of vascular complications in adolescents engaged in sports. Russian Pediatric Journal. 2020;23(4):240–247. (In Russ.) doi: 10.18821/1560-9561-2020-23-4-240-247
- Dikareva NS, Zarechneva YaI. Tsentry zdorov’ya kak perspektiva formirovaniya zdorovogo obraza zhizni detei i podrostkov. Proceedings of the IV Dal’nevostochnogo meditsinskogo molodezhnogo foruma “Aktual’nye voprosy sovremennoi meditsiny”; Khabarovsk, 2–17 Oct, 2020. Khabarovsk; 2020. P. 191–193.
- Zhukov MYu, Mitrakov NN, Zharkov PA. Post-thrombotic syndrome in children: the current state of the issue. Issues of hematology/oncology and immunopathology in pediatrics. 2020;19(3):139–143. (In Russ.) doi: 10.24287/1726-1708-2020-19-3-139-143
- Elizar’eva LA, Galaktionova MYu, Strozenko LA, et al. Study of the social status of children examined at the health center. Russian Bulletin of Perinatology and Pediatrics. 2020;65(4):196. (In Russ.)
- Krukovich EV, Momot GO, Osipenko EA. Comprehensive assessment of the physical development of children and adolescents at the outpatient stage. Pacific Medical Journal. 2021;(4(86)):85–91. (In Russ.) doi: 10.34215/1609-1175-2021-4-85-91
- Miroshnikova EhV, Dubonos EA, Pivnenko PP. Health Center for children as an effective factor of their health saving. Proceedings of the conference “Aktual’nye problemy realizatsii zdorov’esberegayushchikh tekhnologii v obrazovatel’noi srede”; Rostov State Medical University, Rostov-on-Don, 16–17 April, 2021. Rostov-on-Don; 2021. P. 43–50. (In Russ.)
- Gordeeva OB, Karaseva MS, Lavretskii DE, et al. Multidisciplinary approach to the diagnosis of disorders of coagulation system in childrenwith various pathologies. Lechaschi Vrach. 2022;25(12):59–66. (In Russ.) doi: 10.51793/OS.2022.25.12.010
- Elizar’eva LA, Galaktionova MYu, Strozenko LA, et al. Determination of the frequency of thrombogenic risk factors in the examination of children in the Health Center. Russian Pediatric Journal. 2021;24(6):419–423. doi: 10.46563/1560-9561-2021-24-6-419-423
- Tsaturyan L, Tovmasyan V, Karabekyan E, et al. Specifics of genetic polymorphisms associated with the risk of thrombophilia in adolescent men and women: an ethnic perspective. International Research Journal. 2023;(6(132)). (In Russ.) doi: 10.23670/IRJ.2023.132.55
- Pavlova GP. Variants of thrombophilia polymorphism in children and adolescents. Proceedings of the conference “Kafedra detskikh boleznei i ee vklad v obrazovanie, nauku i praktiku” posvyashchennoi 50-letiyu otkrytiya kursa i 30-letiyu otkrytiya kafedry detskikh boleznei Chuvashskogo gosudarstvennogo universiteta imeni I.N. Ul’yanova; Cheboksary, 02 Nov, 2021. Cheboksary; 2021. P. 148–115. (In Russ.)
- Elizar’eva LA, Strozenko LA, Galaktionova MYu, et al. Quality of life indicators for children with high thrombogenic risk factors. Mother and baby in Kuzbass. 2020;(3(82)):10–15. (In Russ.) doi: 10.24411/2686-7338-2020-10029
- Lugacheva YuG, Suslova TE, Kulagina IV, et al. Polymorphism of folate metabolism genes and thrombotic complications in patients with a functionally single ventricle of the heart. Siberian Journal of Clinical and Experimental Medicine. 2021;36(4):86–91. doi: 10.29001/2073-8552-2021-36-4-86-91
- Ponomarev VS, Skudarnov EV, Strozenko LA. Identification of clinical and anamnestic factors of thrombogenic risk in children. Russian Pediatric Journal. 2022;25(6):427–428. (In Russ.)
- Ponomarev VS. Theoretical and methodological issues of the study of genetic polymorphisms of thrombophilia in children against the background of hemorrhagic syndrome. Intercultural communication in education and medicine. 2023;(2):122–126. (In Russ.)
- Strozenko LA, Skudarnov EV, Lobanov YuF, et al. Distribution of prothrombotic polymorphisms in children with microcirculatory type of bleeding on the background of undifferentiated connective tissue dysplasia. Russian Pediatric Journal. 2020;23(2):85–94. (In Russ.) doi: 10.18821/1560-9561-2020-23-2-85-94
- Ponomarev VS, Skudarnov EV, Strozenko LA, et al. Screening of thrombogenic risk factors in children of the Altai Territory. Russian Pediatric Journal. 2023;26(1):61–66. (In Russ.) doi: 10.46563/1560-9561-2023-26-1-61-66
- Spichak II, Volkova KB, Basharova EV. About modern diagnosis methods and methods for correction of conditions associated with natural anticoagulant deficiency (literature review with own clinical observation). Pediatric Bulletin of the South Urals. 2022;(1):92–105. (In Russ.) doi: 10.34710/Chel.2022.13.90.015
- Kruchinina MV, Kashtanova EV, Gromov AA, et al. Sposob otsenki faktorov individual’nogo trombogennogo riska u patsientov s arterial’noi gipertenziei: metodicheskie rekomendatsii po primeneniyu meditsinskoi tekhnologii. Novosibirsk: Ofset-TM; 2021. 34 p. (In Russ.)
- Khoduleva SA, Silin AE, Romashevskaya IP, et al. Trombogennye faktory riska u detei. Proceedings of the International congress “Mnogoprofil’naya klinika XXI veka. Innovatsii v meditsine 2018”; Saint Petersburg, 05–07 April, 2018. Saint Petersburg: Asterion; 2018. P. 222–223. (In Russ.)
- Nikolaeva MG, Momot AP, Mamaev AN, et al. Thrombotic events in rare forms of genetic thrombophilia. Thrombosis, hemostasis and rheology. 2020;(4):87–94. (In Russ.) doi: 10.25555/THR.2020.4.0950
- Galaktionova MYu, Elizar’eva LA, Strozenko LA, et al. The effectiveness of the health center for children. Russian Bulletin of Perinatology and Pediatrics. 2020;65(4):195. (In Russ.)
- Arash M, Marisol B, Neil AG. Thrombosis in children: Approach to anatomic risks, thrombophilia, prevention, and treatment. Hematol Oncol Clin North Am. 2019;33(3):439–453. doi: 10.1016/j.hoc.2019.01.009
- Hope PW, Rosebella C, Inmaculada A, et al. Secondary thrombosis prevention practice patterns in pediatrics: Results of an international survey. Res Pract Thromb Haemost. 2022;6(3):e12693. doi: 10.1002/rth2.12693
- Lassandro G, Palmieri VV, Palladino V, et al. Venous thromboembolism in children: from diagnosis to management. Int J Environ Res Public Health. 2020;17(14):4993. doi: 10.3390/ijerph17144993
- Yurday Ö, Arzu A, Ünsal Ö. Thromboembolism in children. Indian J Pediatr. 2023. doi: 10.1007/s12098-023-04539-3
- Strozenko LA, Momot AP, Lobanov YuF, et al. Factors of thrombogenic risk and state of teenagers’ health in Barnaul. Journal of Siberian Medical Sciences. 2012;(2). (In Russ.)
- Rebrova OYu. Statisticheskii analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA. Moscow: Media Sfera; 2006. 305 p. (In Russ.)
- Val’d A. Posledovatel’nyi analiz. Moscow; 1960. (In Russ.)
- Gubler EV, Genkin AA. Primenenie neparametricheskikh kriteriev statistiki v mediko-biologicheskikh issledovaniyakh. Leningrad: Meditsina; 1973. 141 p. (In Russ.)
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