Assessment of the physical development of children with and without high thrombogenic risk factors in the Health Center for Children

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Abstract

BACKGROUND: Up to 65% diseases associated with pathological thrombus have been described; more than 100 thrombogenic risk factors leading to vascular accidents have been studied. It is known that physical development is an important indicator of health in children. The relationship between the presence of thrombogenic risk factors in various disorders of physical development in children has been studied.

AIM: To determine the relationship between physical development disorders in children and the presence of thrombogenic risk factors.

MATERIALS AND METHODS: The study included 396 children aged 14–18 years, who underwent physical growth assessment using the sigma deviation method and genetic testing to determine polymorphisms of folate cycle genes and polymorphisms of thrombophilia genes. Statistical processing was carried out using the application package Statistica 10.0 (StatSoft, Inc., USA).

RESULTS: The analysis of anthropometric indicators in children showed that in the group of the patients with thrombogenic risk factors, height and body weight values with average physical disharmonious development due to excess weight were statistically significantly higher than age-reference indicators.

CONCLUSIONS: Based on the results of the study, it has been shown that disharmony in physical development in children with high thrombogenic risk factors may be one of the risk factors for the development of thrombotic conditions.

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About the authors

Lilia A. Elizarieva

Altai State Medical University

Email: dr.liliaye@mail.ru
ORCID iD: 0000-0001-9350-2402
SPIN-code: 2473-4690

Department Assistant

Russian Federation, Barnaul

Marina Yu. Galaktionova

Pskov State University

Email: myugal@mail.ru
ORCID iD: 0000-0001-7437-0512

MD, Dr. Sci. (Med.), Professor

Russian Federation, Pskov

Lyudmila A. Strozenko

Altai State Medical University

Author for correspondence.
Email: agmu_ordinatura@mail.ru
ORCID iD: 0000-0002-8586-1330
SPIN-code: 4116-1023

MD, Dr. Sci. (Med.), Professor

Russian Federation, Barnaul

Yuri F. Lobanov

Altai State Medical University

Email: ped2@agmu.ru
ORCID iD: 0000-0001-6284-1604
SPIN-code: 6515-3794

MD, Dr. Sci. (Med.), Professor

Russian Federation, Barnaul

Irina Yu. Boldenkova

Altai State Medical University

Email: k-propdetbol@asmu.ru
ORCID iD: 0000-0001-9775-2636
SPIN-code: 1005-5989

Cand. Sci. (Pharm.), Assistant Professor

Russian Federation, Barnaul

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2. Figure. Real-time polymerase chain reaction genotyping of the samples using competitive TaqMan probes. HEX — hexachlorofluorescein; FAM — fluorescein. Increased intensity of fluorescein luminescence with homozygote for allele A, hexachlorofluorescein — with homozygote for allele B, both dyes — with a combination of homozygotes for alleles A and B

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