Vol 5, No 1 (2017)



Bubenchikova V.N., Nikitin E.A.


The article present results of the study for a anatomic structure of Campanula rotundifolia grass from Campanulaceae family. Despite its dispersion and application in folk medicine, there are no data about its anatomic structure, therefore to estimate the indices of authenticity and quality of raw materials it is necessary to develop microdiagnostical features in the first place, which could help introducing of thisplant in a medical practice. The purpose of this work is to study anatomical structureof Campanula rotundifolia grass to determine its diagnostic features. Methods. Thestudy for anatomic structure was carried out in accordance with the requirements of State Pharmacopoeia, edition XIII. Micromed laboratory microscope with digital adjutage was used to create microphotoes, Photoshop CC was used for their processing. Result. We have established that stalk epidermis is prosenchymal, slightly winding with straight of splayed end cells. After study for the epidermis cells we established that upper epidermis cells had straight walls and are slightly winding. The cells of lower epidermishave more winding walls with prolong wrinkled cuticule. Presence of simple one-cell, thin wall, rough papillose hair on leaf and stalk epidermis. Cells of epidermis in fauces of corolla are prosenchymal, with winding walls, straight or winding walls in a cup. Papillary excrescences can be found along the cup edges. Stomatal apparatus is anomocytic. Conclusion. As the result of the study we have carried out the research for Campanula rotundifolia grass anatomic structure, and determined microdiagnostic features for determination of raw materials authenticity, which included presence of simple, one-cell, thin-walled, rough papillose hair on both epidermises of a leaf, along the veins, leaf edge, and stalk epidermis, as well as the presence of epidermis cells with papillary excrescences along the edges of leaves and cups. Intercellular canals are situatedalong the veins of flower corolla petals.
Pharmacy & Pharmacology. 2017;5(1):4-11
pages 4-11 views


Saushkina A.S., Zinchuk L.N., Denisov M.A., Shokurov V.A., Goncharov D.V.


A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliancewith the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentiallycounterfeited or poor-quality drugs using the IR spectrometry along the total spectrum.Materials and methods. The objects of research were available in freely availablecommercially available tablets produced by domestic and foreign manufacturers“Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”,  corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products ofone manufacturer and the difference in serial samples of products of different manufacturers.
Pharmacy & Pharmacology. 2017;5(1):12-22
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Voronkov A.V., Luzhnova S.A., Billel S., Osychenko S.A.


According to foreign and Russian researchers a problem of anti-microbial drugs resistance today is not a future forecast but is a serious threat, since it is encounteredin every region of the world and is a risk of health for every person not depending on his age and place of living. Development of efficient and safe medicinal drugs with high antibacterial activity is one of the ways to solve the problem. New derivatives of 1,3-diazinon-4 and their acyclic predecessors exhibit antibacterial activity which conditions their perspective for further development. Toxicological studies are important element of the assessment of chemical compounds safety, considered as potentially perspective for the creation of new medicinal drugs. Particularly, the studies of integral indexes which reflect a dynamics of metabolism process in animal organism, such as their weight and mass coefficients of their organs. The purpose of the work is an estimation of the influence of 30-day administration course of PYATd1, PYATs2, PYATs4, PYATd12, PYATs3, PYATd8 on a general condition, weight dynamics and mass coefficients of the rats’ organs. Materials and methods. The studies used 120 both gender Wistar rats weighed 190-210 g. Fourteen groups by 7-10 animals were formed. The compounds were injected through a probe into a stomach at dose 50 mg/kg once a day in the morning. Every day visual examination of animals was carried out during the compounds injection, and peculiarities of their actions were noted. On the 31st day, the animals were weighed, and then removed from the experiment by decapitation using anesthesia (intraabdominal injection of hydrochloride at dose 350 mg/kg). Internals (heart, lungs, stomach, spleen, kidneys, liver, adrenals, brain) were extracted, weighed, and their mass coefficients were calculated. Results and discussion. The study conducted showed that 30-day administration of the compounds does not lead to pathologic weight loss and significant changes of mass coefficients of the animals’internals, which gives evidence about the absence of compounds’ toxic influence on the organism.
Pharmacy & Pharmacology. 2017;5(1):23-34
pages 23-34 views


Ganicheva L.V., Lyakhov A.I.


Rhinitis of different etiology is a timely problem of contemporary otolaryngology.Selective α2-adrenomimetics is one of the drug groups widely used in pharmacotherapy of these diseases. In large part these drugs belong to OTC-drugs, which makes the detailed discussion of pharmaceutic consulting issues very timely. Diversity of these drugs is a circumstance of no small importance, which creates some problems in formation of a rational range in pharmacy organizations. Considering all mentioned above, the marketing analysis of a market for further development of pharmaceuticconsulting algorithm, as well as methodic approaches to the formation of a rational range in pharmacy organizations is very timely. The purpose of the study: the analysis of the Russian market of selective α2-adrenomimetic medicinal drugs, applied in therapy of rhinitis of different etiology for detailed consideration of pharmaceuticconsultation issues and formation of a rational range. Materials and methods. Duringthe studies we carried out a content analysis base on the data from the State Register of Medicinal Drugs, and Register of Medicinal Drugs as of November 1, 2016. Results and discussion. As the result of the analysis we have established that Xylomethazoline was the leader of the Russian pharmaceutical market by the number of registered tradenames. The bigger part of the market is occupied by mono-preparations; nasal spraysand nasal drops are dominant. The Russian market is represented mainly by the Russiaproduced drugs. Naphthyzin, Nazivin, and Otrivin are the leaders by the number of information requests in RMD 2016 system. Conclusion. Followed by the results of thestudies we have obtained the date which can be used while developing the principlesand algorithm of pharmaceutical consulting, as well as for formation of rationalrange of selective α2-adrenomimetic medicinal drugs, applied for therapy of rhinitis ofdifferent etiology.
Pharmacy & Pharmacology. 2017;5(1):35-48
pages 35-48 views


Samoshchenkova I.F., Garankina R.Y.


The main principle of the category management is the management of product category as a separate business unit. Category management directs the activities of the pharmaceutical organization to meet the consumer requirements and to provide customers with maximum benefits, which are expressed in the improved assortment,the attractive prices, the reduction of cases of lack of necessary goods, the simplifiedpurchase process. In article the structure of the category management and its role inthe minimum pharmaceutical assortment, a complex of the theoretical and practical issues affecting interrelation of the list of vital and essential medicines and the minimum range of medicines are considered. A number of the new elements supplementing the concept of category management is offered, and the corresponding generalizations are made. The objective of the research is to study the influence of category management on the structure in management of the minimum assortment of medicines of the pharmaceutical organization. Materials and methods. In the course of the solution of the set tasks, the methods of marketing and economic-mathematical analysis were used. Results and discussion. In the analysis of the assortment list of medicines for medical application, which is obligatory for the pharmaceutical enterprises of all forms of ownership, it was revealed that this assortment list is based on the List of Vital Essential and Necessary (VEN) Drugs. The results of the analysis of the obligatory assortment list from the position of internal category management showed that 77.45% are medicines of the list of VEN Drugs; 46.08% are medicines of non-prescription dispensing. Proceeding from this it follows that the worthy, profitable price policy can be conducted only with 22.55% of the list; to develop standards of merchandising with 46.05%. The category management gives an opportunity to the pharmaceutical organization to specify its competitive strategy and to plan actions for management of the range. Conclusion. Advantages of the application of the category management in management of the minimum range of medicines of the pharmaceutical organization consist in the increase in the effectiveness of measures to stimulate demand, competitive pricing, and efficient merchandising. One of the main functions of the category management is to enhance the effectiveness of the interaction between the distributor (the supplier, the manufacturer) and the pharmaceutical organization.
Pharmacy & Pharmacology. 2017;5(1):49-63
pages 49-63 views

“Antidotarium ” of Nicholas of Salerno : the history of the pharmacopoeia

Voronov F.D., Ruzhinskaya I.N.


The purpose of the article is a textual analysis and identification of practical relevancein the contemporary world of medieval manuscript “Antidotarium” of Nicholas of Salerno – an essential source for the history of pharmacy, containing samples of prescription formulas, leading its history through nine centuries, and tested empirically in countless patients. Materials and methods. To achieve this goal we have analyzed, compared and reviewed existing thematic complexes of literary and historical sources available in medieval medicine, including existing official translations of this manuscript. The result is a detailed analysis and comparison of the original manuscript of the XII th century and the official translations of “Antidotarium” of Nicholas of Salerno in medieval English, Dutch and French. The authors are also discussing the identity of the Nicholas of Salerno and the history of his manuscript, its editing, and the influence that the book has provided on the development and evolution of medicine and pharmacy in Europe as a whole. Conclusion. By defining and showing the history of the “Antidotarium” of Nicholas of Salerno, the authors give an opinion on the high practical significance of this manuscript and the possibility of applying the manuscript formulas in the modern world of evidentiary scientific medicine. The question of the need to translate the medieval source into the Russian language is raised, which will make it possible for the first time in Russian literature to examine in detail the rich medieval prescription of “Antidotarium”, and the need for a further careful and detailed analysis of the translation of the manuscript into the realities of modern evidentiary medicine, rational pharmacotherapy and herbal medicine. Authors have the option of making the translation from medieval French, as one of the closest to the classical Latin languages.
Pharmacy & Pharmacology. 2017;5(1):64-77
pages 64-77 views

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