Vol 5, No 1 (2017)

The article present results of the study for a anatomic structure of Campanula rotundifolia grass from Campanulaceae family. Despite its dispersion and application in folk medicine, there are no data about its anatomic structure, therefore to estimate the indices of authenticity and quality of raw materials it is necessary to develop microdiagnostical features in the first place, which could help introducing of thisplant in a medical practice. The purpose of this work is to study anatomical structureof Campanula rotundifolia grass to determine its diagnostic features. Methods. Thestudy for anatomic structure was carried out in accordance with the requirements of State Pharmacopoeia, edition XIII. Micromed laboratory microscope with digital adjutage was used to create microphotoes, Photoshop CC was used for their processing. Result. We have established that stalk epidermis is prosenchymal, slightly winding with straight of splayed end cells. After study for the epidermis cells we established that upper epidermis cells had straight walls and are slightly winding. The cells of lower epidermishave more winding walls with prolong wrinkled cuticule. Presence of simple one-cell, thin wall, rough papillose hair on leaf and stalk epidermis. Cells of epidermis in fauces of corolla are prosenchymal, with winding walls, straight or winding walls in a cup. Papillary excrescences can be found along the cup edges. Stomatal apparatus is anomocytic. Conclusion. As the result of the study we have carried out the research for Campanula rotundifolia grass anatomic structure, and determined microdiagnostic features for determination of raw materials authenticity, which included presence of simple, one-cell, thin-walled, rough papillose hair on both epidermises of a leaf, along the veins, leaf edge, and stalk epidermis, as well as the presence of epidermis cells with papillary excrescences along the edges of leaves and cups. Intercellular canals are situatedalong the veins of flower corolla petals.

According to foreign and Russian researchers a problem of anti-microbial drugs resistance today is not a future forecast but is a serious threat, since it is encounteredin every region of the world and is a risk of health for every person not depending on his age and place of living. Development of efficient and safe medicinal drugs with high antibacterial activity is one of the ways to solve the problem. New derivatives of 1,3-diazinon-4 and their acyclic predecessors exhibit antibacterial activity which conditions their perspective for further development. Toxicological studies are important element of the assessment of chemical compounds safety, considered as potentially perspective for the creation of new medicinal drugs. Particularly, the studies of integral indexes which reflect a dynamics of metabolism process in animal organism, such as their weight and mass coefficients of their organs. The purpose of the work is an estimation of the influence of 30-day administration course of PYATd1, PYATs2, PYATs4, PYATd12, PYATs3, PYATd8 on a general condition, weight dynamics and mass coefficients of the rats’ organs. Materials and methods. The studies used 120 both gender Wistar rats weighed 190-210 g. Fourteen groups by 7-10 animals were formed. The compounds were injected through a probe into a stomach at dose 50 mg/kg once a day in the morning. Every day visual examination of animals was carried out during the compounds injection, and peculiarities of their actions were noted. On the 31st day, the animals were weighed, and then removed from the experiment by decapitation using anesthesia (intraabdominal injection of hydrochloride at dose 350 mg/kg). Internals (heart, lungs, stomach, spleen, kidneys, liver, adrenals, brain) were extracted, weighed, and their mass coefficients were calculated. Results and discussion. The study conducted showed that 30-day administration of the compounds does not lead to pathologic weight loss and significant changes of mass coefficients of the animals’internals, which gives evidence about the absence of compounds’ toxic influence on the organism.

The main principle of the category management is the management of product category as a separate business unit. Category management directs the activities of the pharmaceutical organization to meet the consumer requirements and to provide customers with maximum benefits, which are expressed in the improved assortment,the attractive prices, the reduction of cases of lack of necessary goods, the simplifiedpurchase process. In article the structure of the category management and its role inthe minimum pharmaceutical assortment, a complex of the theoretical and practical issues affecting interrelation of the list of vital and essential medicines and the minimum range of medicines are considered. A number of the new elements supplementing the concept of category management is offered, and the corresponding generalizations are made. The objective of the research is to study the influence of category management on the structure in management of the minimum assortment of medicines of the pharmaceutical organization. Materials and methods. In the course of the solution of the set tasks, the methods of marketing and economic-mathematical analysis were used. Results and discussion. In the analysis of the assortment list of medicines for medical application, which is obligatory for the pharmaceutical enterprises of all forms of ownership, it was revealed that this assortment list is based on the List of Vital Essential and Necessary (VEN) Drugs. The results of the analysis of the obligatory assortment list from the position of internal category management showed that 77.45% are medicines of the list of VEN Drugs; 46.08% are medicines of non-prescription dispensing. Proceeding from this it follows that the worthy, profitable price policy can be conducted only with 22.55% of the list; to develop standards of merchandising with 46.05%. The category management gives an opportunity to the pharmaceutical organization to specify its competitive strategy and to plan actions for management of the range. Conclusion. Advantages of the application of the category management in management of the minimum range of medicines of the pharmaceutical organization consist in the increase in the effectiveness of measures to stimulate demand, competitive pricing, and efficient merchandising. One of the main functions of the category management is to enhance the effectiveness of the interaction between the distributor (the supplier, the manufacturer) and the pharmaceutical organization.