Astressin, an antagonist of CRF receptors, reduces anxiety and fobial states in rats reared in social isolation conditions

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Abstract

The influence of intranasal administration of astressin, a nonselective antagonist of CRF receptors, on delayed effects of chronic social isolation in the five first weeks after mother leaving on explorative and emotional behavior in rats was studied. Social exposures were applied from 21st to 93rd days of life. The rats reared in social isolation demonstrated higher level of motor activity compared with control in open field test. The assessment of both anxiety and fobial state and behavior in elevated plus maze revealed higher levels in anxiety and fear in isolated rats. Intranasal administration of astressin (1 µg/1µl, 20 µl, 10 µl in every nostrils) reduced significantly anxiety and fear levels in isolated rats. Therefore, both anxiolytic and antifobial effects of astressin, a nonselective antagonist of CRF receptors, were demonstrated in rats exposured to social isolation stress. The results support the idea taking into account the corticoliberin mechanisms in formation of social isolation syndrome and possibilities of using CRF antagonists to control the central stress mechanisms and dependence in ontogeny.

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About the authors

Andrei A Lebedev

Institute of Experimental Medicine

Author for correspondence.
Email: aalebedev-iem@rambler.ru
Dr. Biol. Sci. (Pharmacology), Leading Researcher, SV Anichkov Dept. of Neuropharmacology Russian Federation

Anna G Pshenichnaya

Institute of Experimental Medicine

Email: pshenichnaya@mail.ru
Researcher, SV Anichkov Dept. of Neuropharmacology Russian Federation

Eugenii R Bychkov

Institute of Experimental Medicine

Email: bychkov@mail.ru
PhD (Biochemistry), Leading Researcher, SV Anichkov Dept. of Neuropharmacology Russian Federation

Natalia D Yakushina

Institute of Experimental Medicine

Email: yakushina@mail.ru
Post-graduate Student, SV Anichkov Dept. of Neuropharmacology Russian Federation

Petr D Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor, Head, SV Anichkov Dept. of Neuropharmacology Russian Federation

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Copyright (c) 2016 Lebedev A.A., Pshenichnaya A.G., Bychkov E.R., Yakushina N.D., Shabanov P.D.

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